A5004893995- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Enzyme Catalysis and Immobilization
- Sulfur-Based Synthesis Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Synthesis and biological activity
- Chemical synthesis and pharmacological studies
- Chemical Synthesis and Reactions
- Connective tissue disorders research
- Pesticide and Herbicide Environmental Studies
- Catalytic Cross-Coupling Reactions
- Graphene research and applications
- Laser-Ablation Synthesis of Nanoparticles
- Synthesis and Reactivity of Sulfur-Containing Compounds
- 2D Materials and Applications
- Multicomponent Synthesis of Heterocycles
- Molecular Junctions and Nanostructures
- Asymmetric Synthesis and Catalysis
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Protease and Inhibitor Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biochemical Acid Research Studies
- Insect Pest Control Strategies
University of Tübingen
2020-2024
Syngenta (Switzerland)
2003-2020
Novartis (Switzerland)
2000-2014
Novartis Institutes for BioMedical Research
2014
ETH Zurich
1988-2003
University of Michigan
1988-1997
Ann Arbor Center for Independent Living
1988-1989
Analytisches Laboratorium
1960
Abstract The use of flow photochemistry and its apparent superiority over batch has been reported by a number groups in recent years. To rigorously determine whether does indeed have an advantage batch, broad range synthetic photochemical transformations were optimized both reactor modes their yields productivities compared. Surprisingly, essentially identical all comparative cases. Even more revealing was the observation that productivity reactors varied very little to counterparts when key...
A focused collection of organic synthesis reactions for computer-based molecule construction is presented. It inspired by real-world chemistry and has been compiled in close collaboration with medicinal chemists to achieve high practical relevance. Virtual molecules assembled from existing starting material connected these are supposed have an enhanced chance be amenable real chemical synthesis. About 50% the dataset ring-forming reactions, which fosters assembly novel ring systems...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[3 + 3]-Carbocyclizations of nitroallylic esters and enamines with stereoselective formation up to six new stereogenic centersDieter Seebach, Martin Missbach, Giorgio Calderari, EberleCite this: J. Am. Chem. Soc. 1990, 112, 21, 7625–7638Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://doi.org/10.1021/ja00177a026RIGHTS & PERMISSIONSArticle Views966Altmetric-Citations82LEARN...
Abstract The naturally occurring enantiomer of mevalolactone is shown to possess the (R) ‐(−)‐configuration XVIII by a direct correlation its antipode with quinic acid.
In the search for new bioactive compounds, there is a trend toward increasingly complex compound libraries aiming to target demanding targets of future. contrast, medicinal chemistry and traditional library design rely mainly on small set highly established robust reactions. Here, we probe 58 such reactions their ability sample chemical space known molecules, potential create scaffolds. Combined with ∼26 000 common available building blocks, retrieve around 9% scaffold-diverse compounds...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular yardsticks. Synthesis of extended equilibrium transfer alkylating cross-link reagents and their use in the formation macrocyclesStephen J. Brocchini, Martin. Eberle, Richard G. LawtonCite this: Am. Chem. Soc. 1988, 110, 15, 5211–5212Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July...
Enantioselective Saponification of Diacetates 2‐Nitro‐1,3‐propanediols by Pig‐Liver Esterase and Preparation Enantiomerically Pure Derivatives 2‐Nitro‐allylic Alcohols (Chiral Multiple‐Coupling Reagents) The reproducible enantioselective saponification open‐chain cyclic diacetates meso ‐2‐nitro‐1,3‐propanediols (see 4b – 13b ) with pig‐liver esterase (PLE) gives monoacetates 4c l3c > 95% enantiomeric excess. Re enantiotopic acetate group appears to be saponified preferentially, as proved...
Reduction of ethyl 4-t-butoxy-3-oxobutanoate with fermenting yeast yields (R)-ethyl 4-t-butoxy-3-hydroxybutanoate in 97% e.e. Since the protective group is readily removed from product reduction, present procedure provides a simple entry to "world chiral blocks" formally derived (R)-malic acid.
Abstract Self‐powered ultrafast 2D photodetectors have demonstrated great potential in imaging, sensing, and communication. Understanding the intrinsic charge carrier generation separation processes is essential for achieving high‐performance devices. However, probing manipulating photoresponse limited either by temporal resolution of conventional methods or required sophisticated device configurations. Here, van der Waals heterostructure are constructed based on MoS 2 /WSe p–n n–n junctions...
Introducing a fast, reliable, and flexible “Direct Laser Writing” technology for printing precise complex SERS-patters on different substrates of any desired structure with nanometer resolution applications in sensor optoelectronics.
Abstract Flexible electronics manufacturing technologies are essential and highly favored for future integrated photonic electronic devices. Direct laser induced writing (DIW) of metals has shown potential as a fast variable method in adaptable electronics. However, most the DIW procedures use silver structures, which tend to oxidize limited micrometer regime. Here, technique is introduced that not only enables electrical gold wiring 2D van‐der‐Waals materials with sub‐µm structures 100 nm...
Thioester-mediated peptide bond formation has recently garnered a lot of attention, most notably in its relevance to condensation large fragments. Herein, simple and general ligation method for the preparation linear cyclic peptides, starting from thioester, mainly p-chlorophenyl, precursors is reported. The inherent advantages this are low epimerization, reduced dimerization, use mild reaction conditions, elimination superfluous coupling reagents.
Understanding the fundamental charge carrier dynamics is of great significance for photodetectors with both high speed and responsivity. Devices based on two-dimensional (2D) transition metal dichalcogenides can exhibit picosecond photoresponse speed. However, 2D materials naturally have low absorption, when increasing thickness to gain higher responsivity, response time usually slows nanoseconds, limiting their photodetection performance. Here, by taking time-resolved photocurrent...
Abstract Mechanically controllable break junctions are one suitable approach to generate atomic point contacts and ultrasmall gaps between two metal contacts. For constant bias voltages, the tunneling current can be used as a ruler evaluate distance in sub-1-nm regime with sub-Å precision. This measure plasmonic nanostructures located at designated breaking of junction. In this work, an experimental setup together nanofabricated is developed that enables us perform simultaneous gap-dependent...
Abstract Thioalkylated Meldrum 's acid is easily by treatment of with an aldehyde and thiophenol in the presence catalytical amounts piperidinium acetate (→ 1–6 , Table 1 ). The adducts are crystalline, stable compounds they can be caused to react directly nucleophiles dienes (see 3→7–12 Scheme regeneration parent olefin effected thereby simply dissolving adduct under neutral or basic conditions. Extension this method thiocarboxylic acids allowed preparation corresponding formaldehyde...
A sequential Sonogashira coupling of a protected acetylene precursor with aryl halides (5) followed by pyrazolyl iodides ( 14) allows efficient access to the unsymmetrical aryl-heteroarylacetylene (8).Subsequent regioselective lithiation exchange dimethyl oxalate quench produced readily vicinal ketoesters (9) which show auxin effects in wide variety plant species.
A new generation of insect-growth-regulator insecticides, the azines, are presented. They inhibit chitin biosynthesis process and active against lepidopteran pests. Their synthesis a structure–activity relationship will be discussed.
The search for new active molecules with novel modes of action and desirable physical properties is an ongoing endeavour. This publication describes the follow-up chemistry a biological hit discovered in screening system Novartis Crop Protection, legacy agrochemical parent Syngenta Protection. was optimized through classical synthetic methods automated parallel synthesis coverage important such as lipophilicity or Clog P solubility. Preliminary activity from greenhouse field data...
The preparation of novel acetic acid derivatives pyrazole 3a,b and pyrimidine 2a—e is achieved by condensation dimethyl acetylsuccinate (1) with appropriate reaction partners. Also triethyl 1,1,2-ethanetricarboxylate (6) a valuable starting material, which demonstrated the synthesis previously unknown pyrimidin-5-yl acetates.
Abstract Diacetates of meso‐2‐nitro‐1,3‐diols, readily prepared from nitroalkanes and aldehydes, are saponified by pig liver esterase (PLE) to yield the enantiomerically pure monoacetates.
The preparation of novel acetic acid derivatives pyrazole 3a,b and pyrimidine 2a—e is achieved by condensation dimethyl acetylsuccinate (1) with appropriate reaction partners. Also triethyl 1,1,2-ethanetricarboxylate (6) a valuable starting material, which demonstrated the synthesis previously unknown pyrimidin-5-yl acetates.