A5063891801- Fluorine in Organic Chemistry
- Analytical Chemistry and Sensors
- Electrochemical Analysis and Applications
- Protein Degradation and Inhibitors
- Synthesis and Biological Evaluation
- Vanadium and Halogenation Chemistry
- Advanced Chemical Sensor Technologies
- Inorganic Fluorides and Related Compounds
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Click Chemistry and Applications
- Chemical Synthesis and Reactions
- Electrochemical sensors and biosensors
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Analytical chemistry methods development
- Synthesis and Reactions of Organic Compounds
- Oxidative Organic Chemistry Reactions
- Cancer therapeutics and mechanisms
- Organic Chemistry Cycloaddition Reactions
- Geographic Information Systems Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
ZHAW Zurich University of Applied Sciences
2018-2022
University of Oxford
2014-2021
University of Bern
2015
Geological Survey of Ireland
1998
Tel Aviv University
1980-1990
Imperial College London
1968-1974
University at Buffalo, State University of New York
1969
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputer approach to ion-selective electrode potentiometry by standard addition methodsMichael J. D. Brand and Garry A. RechnitzCite this: Anal. Chem. 1970, 42, 11, 1172–1177Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/ac60293a018https://doi.org/10.1021/ac60293a018research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract Herein, we report the discovery of first potent and selective inhibitor TRPV6, a calcium channel overexpressed in breast prostate cancer, its use to test effect blocking TRPV6‐mediated Ca 2+ ‐influx on cell growth. The was discovered through computational method, xLOS, 3D‐shape pharmacophore similarity algorithm, type ligand‐based virtual screening (LBVS) method described briefly here. Starting with single weakly active seed molecule, two successive rounds LBVS followed by...
Protein modification by interferon-stimulated gene 15 (ISG15), termed ISGylation, exhibits antiviral properties and influences tumorigenesis, genome stability metabolic processes. ISGylation is counteracted the specific protease USP18. Likewise, viral proteases such as papain-like (PLpro) from SARS-CoV-2 cleave ISG15 to undermine host immune response. Beyond its role a deISGylating enzyme, USP18 acts major negative regulator of IFN signaling pathway in STAT2-dependent manner. In humans,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new method for introducing iodo and bromo fluorides into organic molecules using elemental fluorineShlomo Rozen Michael BrandCite this: J. Org. Chem. 1985, 50, 18, 3342–3348Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jo00218a020https://doi.org/10.1021/jo00218a020research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors affecting the response time of a calcium selective liquid membrane electrodeBernard. Fleet, T. H. Ryan, and M. J. D. BrandCite this: Anal. Chem. 1974, 46, 1, 12–15Publication Date (Print):January 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/ac60337a036https://doi.org/10.1021/ac60337a036research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDifferential potentiometry with ion-selective electrodes. New instrumental approachMichael J. D. Brand and Garry A. RechnitzCite this: Anal. Chem. 1970, 42, 6, 616–622Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 1970https://pubs.acs.org/doi/10.1021/ac60288a025https://doi.org/10.1021/ac60288a025research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations28LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic studies on crystal-membrane ion-selective electrodesMichael J. D. Brand and Garry A. RechnitzCite this: Anal. Chem. 1970, 42, 4, 478–483Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/ac60286a004https://doi.org/10.1021/ac60286a004research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations36LEARN ABOUT THESE...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel method for constructing a difluoromethylene group via the reaction of alkynes with bromine fluoride and iodine prepared directly from corresponding elementsShlomo Rozen Michael BrandCite this: J. Org. Chem. 1986, 51, 2, 222–225Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://doi.org/10.1021/jo00352a017RIGHTS & PERMISSIONSArticle Views322Altmetric-Citations51LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic studies of ion-selective glass membrane electrodesM. J. D. Brand and Garry A. RechnitzCite this: Anal. Chem. 1969, 41, 13, 1788–1793Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://doi.org/10.1021/ac60282a009RIGHTS & PERMISSIONSArticle Views139Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads...
CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making them important transcriptional co-activators key nodes in the protein-protein interactome. The bromodomains of enable binding acetylated residues from histones a number other including p53, p73, E2F, GATA1. Here, we report work to develop high-affinity, small-molecule ligand...
Not fluorinated compounds but rather epoxides are formed in good yields from alkenes with the reagent F 2 /MeCN/H O. Both a terminal double bond, which especially sensitive to oxidation, and enones react smoothly.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTertiary hydroxylation using fluorine: activation of the carbon-hydrogen bondShlomo Rozen, Michael Brand, and Moshe KolCite this: J. Am. Chem. Soc. 1989, 111, 21, 8325–8326Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ja00203a069https://doi.org/10.1021/ja00203a069research-articleACS PublicationsRequest reuse permissionsArticle...
Cathodic stripping analysis has been shown to be an extremely sensitive technique for the determination of compounds that form insoluble mercury salts. The experimental parameters governing application this have studied and applied sodium diethyl-dithiocarbamate. results obtained were compared with those from conventional d.c. polarography, a.c. polarography linear potential-sweep chrono-amperometry.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImpedance measurements on ion-selective liquid-membrane electrodesM. J. D. Brand and Garry A. RechnitzCite this: Anal. Chem. 1969, 41, 10, 1185–1191Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ac60279a013https://doi.org/10.1021/ac60279a013research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations20LEARN ABOUT...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic bromination using bromine fluoride with no Friedel-Crafts catalystShlomo Rozen, Michael Brand, and Rami LidorCite this: J. Org. Chem. 1988, 53, 23, 5545–5547Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/jo00258a030https://doi.org/10.1021/jo00258a030research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract A new solid-state cadmium ion selective electrode is evaluated. Interference effects are considered and the used to detect endpoint in titrations of water dimethylsulfoxide.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel transformation of a carbonyl to CF2 groupShlomo Rozen, Michael Brand, and Dov ZamirCite this: J. Am. Chem. Soc. 1987, 109, 3, 896–897Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/ja00237a043https://doi.org/10.1021/ja00237a043research-articleACS PublicationsRequest reuse permissionsArticle Views520Altmetric-Citations27LEARN ABOUT THESE...
Sentrin-specific proteases (SENPs) are responsible for the maturation of small ubiquitin-like modifiers (SUMOs) and deconjugation SUMOs from their substrate proteins. Studies on prostate cancer revealed an overexpression SENP1, which promotes progression as well metastasis. Therefore, SENP1 has been identified a novel drug target against cancer. Herein, we report discovery biological evaluation potent selective inhibitors. A structure-activity relationship (SAR) newly pyridone scaffold...
SUMOylation is a reversible post-translational modification (PTM) involving covalent attachment of small ubiquitin-related modifier (SUMO) proteins to substrate proteins. Dysregulation and deSUMOylation results in cellular malfunction linked various diseases, such as cancer. Sentrin-specific proteases (SENPs) were identified for the maturation SUMOs deconjugation from their Hence, this promising target tackling dysregulation process. Herein, we report discovery novel protein-protein...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStamping out misconceptionsJ. D. Bradley and M. Brand Cite this: J. Chem. Educ. 1985, 62, 4, 318Publication Date (Print):April 1, 1985Publication History Received3 August 2009Published online1 April 1985Published inissue 1 1985https://doi.org/10.1021/ed062p318RIGHTS & PERMISSIONSArticle Views278Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF HTML)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophilic attack of elemental fluorine on organic halogens. Synthesis fluoroadamantanesShlomo Rozen and Michael BrandCite this: J. Org. Chem. 1981, 46, 4, 733–736Publication Date (Print):February 1, 1981Publication History Published online1 May 2002Published inissue 1 February 1981https://pubs.acs.org/doi/10.1021/jo00317a016https://doi.org/10.1021/jo00317a016research-articleACS PublicationsRequest reuse permissionsArticle...