A direct cross-coupling reaction of aromatic aldehydes with potassium trifluoro(organo)borates afforded ketones in high yields and under mild conditions the presence a rhodium catalyst acetone. This new reaction, involving formal aldehyde C−H bond activation, is believed to proceed via Heck-type mechanism followed by hydride transfer

Potassium organotrifluoroborates, highly stable organoboron derivatives, participate in asymmetric 1,4-additions to enones. This reaction, catalyzed by cationic rhodium(I) complexes chelated with binap, MeO-biphep or josiphos ligand, affords 1,4-adducts high yields and enantioselectivities of up 99%. Careful study the reaction parameters shows sensitivity temperature, solvent amount water cosolvent. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)

MreB, the bacterial actin-like cytoskeleton, is required for rod morphology of many species. Disruption MreB function results in loss and cell rounding. Here, we show that widely used inhibitor A22 causes MreB-independent growth inhibition varies with drug concentration, culture medium conditions, species tested. MP265, an structural analog, less toxic than yet equally efficient disrupting cytoskeleton. The action MP265 enhanced by basic pH medium. Using this knowledge rapid reversibility...

A new approach to improve the cellulase stability against 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]), based on coating of immobilized enzyme particles with hydrophobic ILs, is proposed. The commercial (Celluclast®), onto a polymeric support (Amberlite XAD4), was first studied in ten different ionic liquids (ILs) at 50 and 80 °C. Hydrophobic ILs clearly enhanced thermal stability. Butyltrimethyl-ammonium bis(trifluoromethylsulfonyl)imide ([N1114][NTf2]) enhances half-life time °C up 4...

Quick test for quicksilver: A microdevice liquid–liquid extraction and sensing of mercury ions in water uses an ionic liquid containing a task-specific fluorogenic salt (L1) as the extracting phase. The “off–on” response decreases likelihood false positives allows detection Hg2+ aqueous solution down to 50 ppb. Detailed facts importance specialist readers are published ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by...

Abstract Complementary to previously described Miyaura borylation methods, a new access boron derivatives via aryl(amino)boranes is described. Direct coupling between aryldiazonium salts and diisopropylaminoborane catalysed by 0.1% ferrocene leading the formation of carbon‐boron bond. The obtained could eventually then be transformed into boronic acids, boronates or borates.

Abstract The synthesis of arylboronic ester derivatives from aryl chlorides by using aryl(amino)boranes is described. Palladium‐catalyzed coupling between and diisopropylaminoborane leads to the formation a CB bond under mild conditions. A wide range functional groups are tolerated, making this method particularly useful for borylation functionalized aromatics.

On the surface: A library of organic–inorganic hybrid palladium nanocrystals was synthesized using continuous supercritical microfluidic technology. The nanocatalysts show moderate to excellent activities towards CArB and CArCAr bond-forming reactions, thus illustrating relationship between surface properties modulated catalytic activity. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset....

In situ formation of aryl Grignard under Barbier condition and diisopropylaminoborane as boron source allows a complete control the addition onto electrophile. Analytically pure borinic acid derivatives were produced at gram scale without column chromatography isolated borinates adducts, with ethanolamine or 8-hydroxyquinoline, after workup.

The SF 5 Cl radical addition on unsaturated compounds was performed using an air-stable amine–borane complex as the initiator. This method showed to be complementary classic Et 3 B-mediated alkenes and alkynes. A total of seven alkene three alkyne derivatives were tested in reaction, with yields ranging from 3% 85%.

Abstract The copper‐catalyzed azide alkyne [3+2]‐cycloaddition (CuAAC) reaction of organoboranes represents an attractive area research within the field click chemistry, with diverse applications in organic synthesis, medicinal or materials science. Despite potential issues caused by copper insertion into carbon‐boron bond, significant progress has been made to harness reactivity organoboron compounds CuAAC. This review provides overview catalytic methods reported for CuAAC various...

Efficient introduction of perfluorinated tails onto aromatic rings has been achieved by Heck reaction between perfluoroalkenes and arenediazonium salts, catalysed palladium acetate. Subsequent transition metal hydrogenation the double bond afforded a large variety compounds bearing an affinity for fluorous solvents. Formation perfluoroalkylated phosphane ligands their use in palladium-catalysed coupling potassium trifluoro(vinyl)borates diazonium salts is also described, allowing easy...

Reaction of potassium aryltrifluoroborates with aldehydes, in the presence a rhodium catalyst, afforded carbinol derivatives high yields under mild aqueous conditions; this efficient reaction proved to be general, allowing production highly hindered diarylmethanols and aliphatic aldehydes were also reactive these conditions.

State of clay: Chiral organic–inorganic hybrid materials based on amino acid-exchanged clays are prepared and used for heterogeneous asymmetric organocatalysis. Co-inclusion ammonium cations within interlayers greatly enhances yields selectivities. Recyclability the material is evaluated, showing no decrease in enantioselectivity or conversion after ten cycles.

A simple metal-free borylation of aryl iodides mediated by a fluoride sp2–sp3 diboron adduct is described. The reaction conditions are compatible with various functional groups. Electronic effects substituents do not affect the while steric hindrance does. proceeds via radical mechanism in which pyridine serves to stabilize boryl radicals, generated situ.

This review highlights the tool box for development of continuous green/sustainable processes aimed at synthesis fine chemicals. By combining either chemical and/or biological catalysts with biphasic systems based on neoteric solvents, e.g. ionic liquids (ILs) and supercritical carbon dioxide (scCO2), interesting alternatives to organic solvents designing clean (bio)transformations methods are growing that directly provide pure products. The classical advantages scCO2 -its ability extract,...

Sequential borylation of a first aryl iodide using dialkylaminoborane followed by Suzuki-Miyaura cross coupling second ended up with an efficient, selective and practical synthesis unsymmetrical biaryls. This tandem shows wide range applicability.