A5069043842- Peptidase Inhibition and Analysis
- Biochemical and Structural Characterization
- Enzyme Production and Characterization
- Bioinformatics and Genomic Networks
- Autophagy in Disease and Therapy
- Computational Drug Discovery Methods
- Protein Hydrolysis and Bioactive Peptides
- Microbial Natural Products and Biosynthesis
- Potato Plant Research
- Meat and Animal Product Quality
- Transgenic Plants and Applications
- Insect Resistance and Genetics
- Pineapple and bromelain studies
- Adenosine and Purinergic Signaling
- Microbial Metabolites in Food Biotechnology
- Advanced Proteomics Techniques and Applications
- Ubiquitin and proteasome pathways
- Proteins in Food Systems
- Endoplasmic Reticulum Stress and Disease
Goethe University Frankfurt
2019-2021
Universidad Nacional de La Plata
2011-2018
Universitat Autònoma de Barcelona
2016-2018
Medigene (Germany)
2017
Centro de Investigaciones Biológicas Margarita Salas
2016
We describe the assembly and annotation of a chemogenomic set protein kinase inhibitors as an open science resource for studying biology. The only includes that show potent inhibition narrow spectrum activity when screened across large panel biochemical assays. Currently, contains 187 cover 215 human kinases. (KCGS), current Version 1.0, is most highly annotated selective available to researchers use in cell-based screens.
Degradation of the endoplasmic reticulum (ER) via selective autophagy (ER-phagy) is vital for cellular homeostasis. We identify FAM134A/RETREG2 and FAM134C/RETREG3 as ER-phagy receptors, which predominantly exist in an inactive state under basal conditions. Upon induction ER stress signal, they can induce significant fragmentation subsequent lysosomal degradation. FAM134A, FAM134B/RETREG1, FAM134C are essential maintaining morphology a LC3-interacting region (LIR)-dependent manner....
Cystine-knot miniproteins (CKMPs) are an intriguing group of cysteine-rich molecules that combine the characteristics proteins and peptides. Typically, CKMPs fewer than 50 residues in length share a characteristic knotted scaffold characterized by presence three intramolecular disulfide bonds form singular structure. The knot confers on these remarkable chemical, thermal, proteolytic stability. Recently, have emerged as novel class natural with interesting pharmacological properties. In...
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress damage maintain homeostasis. Ubiquitination autophagy-related or regulatory components important precise autophagy pathways. Here, we show that deubiquitinase ubiquitin-specific protease 11 (USP11) restricts KO USP11 mammalian cells results elevated autophagic flux. We also demonstrate depletion homolog H34C03.2 Caenorhabditis elegans triggers hyperactivation...
Abstract We describe the assembly and annotation of a chemogenomic set protein kinase inhibitors as an open science resource for studying biology. The only includes that show potent inhibition narrow spectrum activity when screened across large panel biochemical assays. Currently, contains 187 cover 215 human kinases. (KCGS) is most highly annotated selective available to researchers use in cell-based screens.
Metallocarboxypeptidases (MCP) are zinc-dependent exopeptidases that catalyze the hydrolysis of C-terminal amide bonds in proteins and peptides.They involved a wide range physiological processes have recently emerged as relevant drug targets biomedicine (Arolas et al., 2007).In this context, study discovery new MCP inhibitors from plants constitute valuable approach for development therapeutic strategies.Herein we describe simple accessible microplate method specific dose-response...