A5060131715- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
- Metalloenzymes and iron-sulfur proteins
- Porphyrin and Phthalocyanine Chemistry
- Hemoglobin structure and function
- Organometallic Complex Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Electrocatalysts for Energy Conversion
- Enzyme function and inhibition
- Asymmetric Hydrogenation and Catalysis
- DNA and Nucleic Acid Chemistry
- CO2 Reduction Techniques and Catalysts
- Crystal structures of chemical compounds
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Analysis
- Photodynamic Therapy Research Studies
University of California, Santa Cruz
2014-2023
University of California System
2015-2019
University of California, Davis
1998-2008
University College London
2006
University of California, Los Angeles
2006
Fraunhofer Society
2003
University of Washington
2000
University of Georgia
2000
Lawrence Berkeley National Laboratory
2000
University of Delaware
2000
ConspectusThe recent surprising discovery of the beneficial effects carbon monoxide (CO) in mammalian physiology has drawn attention toward site-specific delivery CO to biological targets. To avoid difficulties handling this noxious gas hospital settings, researchers have focused their on metal carbonyl complexes as CO-releasing molecules (CORMs). Because further control such through light-triggering can be achieved with photoactive (photoCORMs), we and other groups attempted isolate past...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray spectroscopic studies of nickel complexes, with application to the structure sites in hydrogenasesGerard J. Colpas, Michael Maroney, Csaba Bagyinka, Manoj Kumar, William S. Willis, Steven L. Suib, Pradip K. Mascharak, and Narayan BaidyaCite this: Inorg. Chem. 1991, 30, 5, 920–928Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://doi.org/10.1021/ic00005a010Request reuse...
Three nitrosyl-dye conjugates, namely, [(Me 2bpb)Ru(NO)(Resf)] ( 1-Resf), 2bQb)Ru(NO)(Resf)] 2-Resf), and [((OMe) 3-Resf) have been synthesized via direct replacement of the chloride ligand parent {Ru-NO} (6) nitrosyls type [(R 2byb)Ru(NO)(L)] with anionic tricyclic dye resorufin (Resf). The structures 1-Resf- 3-Resf determined by X-ray crystallography. is coordinated to ruthenium centers these conjugates phenolato-O atom trans NO. Systematic red shift d pi(Ru) --> pi*(NO) transition due...
Two new manganese complexes derived from the pentadentate ligand N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-quinoline-2-carboxamide, PaPy2QH, where H is dissociable proton), namely, [Mn(PaPy2Q)(NO)]ClO4 (2) and [Mn(PaPy2Q)(OH)]ClO4 (3), have been synthesized structurally characterized. The Mn(III) complex though insensitive to dioxygen, reacts with nitric oxide (NO) afford nitrosyl via reductive nitrosylation. This diamagnetic {Mn-NO}6 exhibits nuNO at 1725 cm-1 highly soluble in water,...
Two Mn(I) carbonyl complexes namely [MnBr(azpy)(CO)3] and [Mn(azpy)(CO)3(PPh3)](ClO4) (azpy = 2-phenylazopyridine) have been synthesized characterized. Both exhibit rapid CO release upon exposure to low power visible light. shows significant phototoxicity toward two malignant cell lines HeLa MDA-MB-231.
Two manganese(I) carbonyl complexes derived from 2-(pyridyl)benzothiazole (pbt) and 1,10-phenanthroline (phen) release carbon monoxide (CO) under low-power broad-band visible-light illumination. CO photorelease [Mn(CO)3(pbt)(PTA)]CF3SO3 (1, where PTA = 1,3,5-triaza-7-phosphaadamantane) is accompanied by an emergence of a strong fluorescence around 400 nm almost nonfluorescent preirradiated 1. However, [Mn(CO)3(phen)(PTA)]CF3SO3 (2) showed no such phenomenon upon prolonged illumination...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[Fe(PMA)]n+ (n = 1,2): good models of iron-bleomycins and examples mononuclear non-heme iron complexes with significant oxygen-activation capabilitiesRichard J. Guajardo, Samuel E. Hudson, Steven Brown, Pradip K. MascharakCite this: Am. Chem. Soc. 1993, 115, 18, 7971–7977Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September...
L-edge X-ray absorption spectroscopy has been used to study, under a variety of conditions, the electronic structure Ni in Ni−Fe hydrogenases from Desulfovibrio gigas, baculatus, and Pyrococcus furiosus. The status enzyme films for these measurements was monitored by FT-IR spectroscopy. spectra were interpreted ligand field multiplet simulations comparison with data model complexes. spectrum D. gigas "form A" is consistent covalent Ni(III) species. In contrast, all reduced samples exhibited...
Reversible NO binding in acetonitrile is observed the non-heme FeIII complex [Fe(PaPy3)(NO)](ClO4)2 (see scheme). The moiety photolabile, and can dissociate from this under very mild conditions. carboxamido nitrogen donor trans to appears play a crucial role photolability. (PaPy3=N-[N,N-bis(2-pyridylmethyl)aminoethyl]-2-pyridinecarboxamide).
As part of our work on models the iron(III) site Fe-containing nitrile hydratase, a designed ligand PyPSH4 with two carboxamide and thiolate donor groups has been synthesized. Reaction (Et4N)[FeCl4] deprotonated form in DMF affords mononuclear complex (Et4N)[FeIII(PyPS)] (1) high yield. The center is trigonal bipyramidal geometry carboxamido nitrogens, one pyridine nitrogen, thiolato sulfurs as donors. Complex 1 stable water binds variety Lewis bases at sixth low temperature to afford green...
The unusual role of CO as a signaling molecule in several physiological pathways has spurred research the area synthesizing new CO-releasing molecules (CORMs) exogenous donors. Auxiliary control on delivery can be achieved if released under light. To synthesize such photoactive CORMs (photoCORMs) with aid smart design, series manganese carbonyls have been synthesized ligands that contain extended conjugation and electron-rich donors their frames. Five photoCORMs, namely,...
The recently discovered cytoprotective action of CO has raised interest in exogenous CO-releasing materials (CORMs) such as metal carbonyls (CO complexes transition metals). To achieve control on delivery with carbonyls, we synthesized and characterized three Mn(I) namely, [Mn(tpa)(CO)3]ClO4 [1, where tpa = tris(2-pyridyl)amine], [Mn(dpa)(CO)3]Br [2, dpa N,N-bis(2-pyridylmethyl)amine], [Mn(pqa)(CO)3]ClO4 [3, pqa (2-pyridylmethyl)(2-quinolylmethyl)amine], by crystallography various...
A family of Re(I) carbonyl complexes general formula [ReX(CO)3(phen)]0/1+ (where X = Cl–, CF3SO3–, MeCN, PPh3, and methylimidazole) derived from 1,10-phenanthroline (phen) exhibits variable emission characteristics depending on the presence sixth ancillary ligand/group (X). All but with MeCN exhibit moderate CO release upon irradiation low-power UV light are indefinitely stable in anaerobic/aerobic environment solution as well solid state when kept under dark condition. These donors liberate...
A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation ligand. results study suggest potential 1 eradication through delivery.
A Re(I) carbonyl complex derived from 2-(2-pyridyl)-benzothiazole (pbt), [Re(H2O)(CO)3(pbt)](CF3SO3) (1), rapidly releases CO under low-power UV illumination. photorelease 1 is accompanied by a change in luminescence orange to deep blue. These two distinct signals have been successfully employed track (a) the entry of pro-drug into cancer cells and (b) end (drug) delivery step within target.
A photoactive manganese nitrosyl, namely [Mn(PaPy(3))(NO)](ClO(4)) ({Mn-NO}), has been loaded into the columnar pores of an MCM-41 host. Strong interaction between polar nitrosyl and -OH groups on host wall leads to excellent entrapment NO donor within porous With aluminosilicate-based (Al-MCM-41), loading is further enhanced due electrostatic cationic species with aluminum sites. The extent determined via analytical techniques including N(2) adsorption/desorption isometry. Powder X-ray...
The surprising discovery of salutary effects low doses carbon monoxide (CO) in mammalian physiology has raised intense research interest CO delivery to biological targets under controlled conditions. In recent attempts, photoactive metal carbonyl complexes (photoCORMs) have been employed trigger release at the target sites. this work, a designed photoCORM namely, fac-[Re(CO)3(pbt) (PPh3)](CF3SO3) (1, pbt =2-(2-pyridyl)benzothiazole) synthesized and characterized by spectroscopic methods...
Abstract The therapeutic potential of photoactive CO‐releasing molecules (photoCORMs) have called for close examination the roles ligand(s) and central metal atoms on overall photochemical labilization metal–CO bonds. Along this line, we synthesized four complexes, namely, [MnBr(azpy)(CO) 3 ] ( 1 ), [Mn(azpy)(CO) (PPh )]ClO 4 2 [ReBr(azpy)(CO) [Re(azpy)(CO) derived from 2‐phenylazopyridine. These complexes were characterized by spectroscopic crystallographic studies. Although both exhibit...