A5012749886- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- High Altitude and Hypoxia
- Respiratory Support and Mechanisms
- Mosquito-borne diseases and control
- Fibroblast Growth Factor Research
- Adipokines, Inflammation, and Metabolic Diseases
- Abdominal Surgery and Complications
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Viral Infections and Vectors
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Advanced Fluorescence Microscopy Techniques
- Airway Management and Intubation Techniques
- Respiratory viral infections research
- HIV Research and Treatment
- Quantum Dots Synthesis And Properties
Regional Centre for Biotechnology
2016-2021
KIIT University
2020-2021
Transcend Vivoscope (China)
2019
Scope Group (United States)
2017
Phospho-Akt1 (pAkt1) undergoes prolyl hydroxylation at Pro125 and Pro313 by the hydroxylase-2 (PHD2) in a reaction decarboxylating α-ketoglutarate (αKG). We investigated whether αKG supplementation could inhibit Akt-mediated activation of platelets monocytes, vitro as well vivo, augmenting PHD2 activity.We treated or monocytes isolated from healthy individuals with presence agonists assessed signalling molecules including pAkt1. supplemented mice dietary estimated functional responses ex...
The maintenance of oxygenation is a commonly encountered problem in obese patients undergoing laparoscopic cholecystectomy. There no specific guideline on the ventilation modes for this group patients. Although several studies have been performed to determine optimal ventilatory settings these patients, answer yet be found. aim study was evaluate efficacy pressure-controlled (PCV) comparison with volume-controlled (VCV) maintaining during cholecystectomy patients.One hundred and two adult...
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and dry age-related macular degeneration, have led to loss of vision in millions individuals. Currently, no surgical or medical treatment is available, although optogenetic therapies are clinical development. We demonstrate restoration using multicharacteristics opsin (MCO1) animal models with degenerated retina. MCO1 reliably delivered specific retinal cells via intravitreal injection adeno-associated virus (vMCO1), leading...
We have previously described an evolutionarily selected Tibetan prolyl hydroxylase-2 (PHD2D4E;C127S) variant that degrades the hypoxia-inducible factor (HIFα) more efficiently and protects these highlanders from hypoxia-triggered elevation in haemoglobin concentration. High altitude is known to cause acute mountain sickness (AMS) high-altitude pulmonary edema (HAPE) a section of rapidly ascending non-acclimatised lowlanders. These morbidities are often accompanied by inflammatory response...
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and dry age-related macular degeneration, have led to loss of vision in millions individuals. Currently, no surgical or medical treatment is available, although optogenetic therapies are clinical development. We demonstrate restoration using multicharacteristics opsin (MCO1) animal models with degenerated retina. MCO1 reliably delivered specific retinal cells via intravitreal injection adeno-associated virus (vMCO1), leading...
Cardiovascular disease (CVD) is the leading cause of death today and a burden on country’s economic growth. Management this continues to depend dietary control statins. However, refuses decline. It probably because treatment regime addresses effect not cause. Augmented LDL level has been traditionally perceived as major risk factor contributing development atherosclerosis, main several coronary ailments. Recent research also suggests that pre-existing chronic inflammation leads oxidation...
ABSTRACT The efficient and targeted delivery of genes other impermeable therapeutic molecules into retinal cells is immense importance for therapy various visual disorders. Traditional methods gene require viral transfection, or chemical that suffer from one many drawbacks such as invasiveness, low efficiency, lack spatially delivery, can generally have deleterious effects unexpected inflammatory responses immunological reactions. Here, we introduce a continuous wave near-infrared...
Abstract Phosphorylation of Akt (pAkt) regulates multiple physiological and pathological processes including thrombosis inflammation. In an approach to inhibit the signalling pAkt by prolyl-hydroxylase-2 (PHD2) we employed α-ketoglutarate (αKG), a cofactor PHD2. Octyl-αKG supplementation platelets promoted PHD2 activity through elevated intracellular αKG:succinate ratio reduced aggregation in vitro suppressing pAkt1(Thr308). Augmented was confirmed increased hydroxylated-proline alongside...