A5085106714- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Blood donation and transfusion practices
- Blood transfusion and management
- Platelet Disorders and Treatments
- Erythropoietin and Anemia Treatment
- Complement system in diseases
- Erythrocyte Function and Pathophysiology
- Advanced MRI Techniques and Applications
- Immune Response and Inflammation
- Blood properties and coagulation
- Immunodeficiency and Autoimmune Disorders
- Hemostasis and retained surgical items
- Retinal and Optic Conditions
- Peripheral Neuropathies and Disorders
- Blood groups and transfusion
Maastricht University Medical Centre
2004-2023
Sanquin
2011-2023
Maastricht University
2004-2020
University of Padua
2019
University Medical Center Utrecht
2014
Masaryk University
2014
Medisch Spectrum Twente
2014
Atrium Medical (Australia)
2011
Radboud University Nijmegen
2007-2011
Radboud University Medical Center
2011
Standard treatment of newly diagnosed HFE hemochromatosis patients is phlebotomy. Erythrocytapheresis provides a new therapeutic modality that can remove up to three times more red blood cells per single procedure and could thus have clinical economic benefit.To compare the number procedures between erythrocytapheresis phlebotomy needed reach serum ferritin (SF) target level 50 µg/L, two-treatment-arms, randomized trial was conducted in which 38 homozygous for C282Y were randomly assigned...
BACKGROUND Phlebotomy is standard maintenance treatment of patients with hereditary hemochromatosis (HH). Erythrocytapheresis, which selectively removes red blood cells, provides a new, potentially more effective option. Our aim was to evaluate the effectiveness erythrocytapheresis over phlebotomy for therapy in HH. STUDY DESIGN AND METHODS We conducted two‐treatment‐arms, randomized, crossover clinical trial, involving 46 patients, treated 1 year either or keep ferritin level at not than 50...
Circulating PLTs have a low activation state and high responsiveness, which ensures adequate hemostatic activity at sites of vessel wall damage. collected for transfusion purposes preferably retained these properties to restore impaired hemostasis with thrombocytopenia.We determined coagulant PLT-plasma preparations that were pooled or from single donors via apheresis.In comparison freshly isolated PLTs, both apheresis exhibited slow exposure CD62 upon storage, followed by surface appearance...
BACKGROUND: Therapeutic phlebotomy is the preferred treatment for iron overload associated with hemochromatosis. In Netherlands, red blood cell concentrates (RCCs) from hemochromatosis patients are not used transfusion purposes. this study, their storage performance was compared that of control donors as a first step in evaluation potential usefulness transfusion. STUDY DESIGN AND METHODS: RCCs were obtained and regular donors, either by apheresis or whole‐blood collection, stored up to 50...
Current treatment for newly diagnosed patients with hereditary hemochromatosis (HH) and iron overload consist of weekly phlebotomy or less frequent more personalized erythrocytapheresis. Previous observations during suggest an increase in intestinal uptake caused by lowering hepcidin as a result intensive bloodletting. It is not known whether such effect present even pronounced using erythrocytapheresis since larger amount extracted per procedure. In this study we aimed to assess the on...
Abstract Introduction For the maintenance treatment of patients with hereditary hemochromatosis (HH), it is advised to keep transferrin saturation (TSAT) <70% prevent formation non‐transferrin‐bound iron and labile plasma iron. The period initial depletion may last up 1 year or longer during this period, patient exposed elevated TSAT levels. Therapeutic erythrocytapheresis (TE) a modality which has proven reduce duration overload from HH. In study, we investigated time reach for both...
In this study we examined whether prestorage leucocyte reduction prevents the accumulation of bioreactive substances in red cell units.Measurements were performed supernatants buffy-coat-depleted (standard cells) and leucocyte-reduced (filtered units. The effect storage was evaluated by taking repetitive samples up to 35 days after donation. We determined concentrations polymorphonuclear neutrophil (PMN)-derived bactericidal permeability increasing protein (BPI), defensins annexin A5....
Standard treatment for naïve hereditary hemochromatosis patients consists of phlebotomy or a personalized erythrocytapheresis. Erythrocytapheresis is more efficient, but infrequently used because perceived costs and specialized equipment being needed. The main aim our study was to develop model that predicts the number initial procedures both methods. This information may help clinician select optimal modality individual patient.We analyzed retrospective data 125 newly diagnosed (C282Y...
Purpose: Reliable prediction of CD34 1 cell mobilization would allow optimization apheresis volumes processed and ensure collection an adequate dose for hematopoietic stem transplantation.However, responses to G-CSF vary considerably in healthy allogeneic peripheral blood (PBSC) donors, no data exist from which estimate a representative, ethnically diverse population.Here, we present analysis the impact factors including baseline demographic laboratory data, dose, premobilization...
Background: Hereditary aceruloplasminemia (HA) is a rare autosomal recessive disorder. It comprises mutations in the ceruloplasmin genes leading to absence of ceruloplasmin, protein required for iron oxidaztion that enables incorporation into transferrin. Due diminished export from storage cells and usually mild anemic state due ineffective incorporation, absorption increased resulting accumulating parenchymal like hepaocytes, insulin producing pancreatic neurons brain may resultin diabetes,...