A5019103042- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Hepatitis B Virus Studies
- Blood transfusion and management
- Hematopoietic Stem Cell Transplantation
- Blood donation and transfusion practices
- Genomics and Phylogenetic Studies
- Platelet Disorders and Treatments
- RNA and protein synthesis mechanisms
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Blood disorders and treatments
- Blood properties and coagulation
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Hematological disorders and diagnostics
- Vascular Tumors and Angiosarcomas
- Multiple Sclerosis Research Studies
- Chromosomal and Genetic Variations
- Breast Cancer Treatment Studies
- Genetic diversity and population structure
- Glycosylation and Glycoproteins Research
Radboud University Nijmegen
2018-2024
Radboud University Medical Center
2018-2024
Sanquin
2014-2020
Leiden University Medical Center
2006-2020
Leiden University
2017
Haga Hospital
2012-2013
Bielefeld University
1998-2007
Marienhospital Gelsenkirchen
1992
Abstract MOTIVATION: We present a new probabilistic model of the evolution RNA-, DNA-, or protein-like sequences and software tool, Rose, that implements this model. Guided by an evolutionary tree, family related is created from common ancestor sequence insertion, deletion substitution characters. During artificial process, 'true' history logged 'correct' multiple alignment simultaneously. The also allows for varying rates mutation within sequences, making it possible to establish so-called...
Autoimmune hemolytic anemia (AIHA) is a rare autoantibody-mediated disease. For steroid and/or rituximab-refractory AIHA, there no consensus on optimal treatment. Daratumumab, monoclonal antibody targeting CD38, could be beneficial by suppression of CD38+ plasma cells and thus autoantibody secretion. In addition, because CD38 also expressed activated T cells, daratumumab may act via immunomodulatory effects. We evaluated the efficacy safety monotherapy in an international retrospective study...
Transfusion of red blood cells from female donors has been associated with increased mortality in male recipients.To quantify the association between cell transfusion and without a history pregnancy recipients.Retrospective cohort study first-time recipients at 6 major Dutch hospitals enrolled May 30, 2005, to September 1, 2015; final follow-up date was 2015. The primary analysis no-donor-mixture (ie, either all transfusions exclusively donors, or pregnancy, pregnancy). exposure...
Background Patients receiving red blood cell ( RBC ) transfusions are at risk of developing alloantibodies against donor antigens. The alloimmunization is dependent on the number units administered and patient's genetic predisposition, but has also been suggested to be modulated by a clinical profile. Our aim was examine whether immunosuppressants suppress development clinically relevant antibodies. Study Design Methods A two‐center case‐referent study performed where case patients control...
Summary Red cell alloantigen exposure can cause alloantibody‐associated morbidity. Murine models have suggested that inflammation modulates red alloimmunisation. This study quantifies alloimmunisation risks during infectious episodes in humans. We performed a multicentre case–control within source population of patients receiving their first and subsequent transfusions an 8‐year follow‐up period. Patients developing transfusion‐induced alloantibody ( N = 505) were each compared with two...
Red cell alloimmunization may induce severe hemolytic side effects. Identification of risk-modifying conditions will help tailor preventative strategies. This study aims to quantify the associations hematologic malignancies and solid cancers with red in patients receiving transfusions. We performed a nested multicenter case-control source population 24,063 their first subsequent transfusions during an 8-year follow-up period. Cases (n=505), defined as developing transfusion-induced...
Recently, therapeutic erythrocytapheresis (TE) was suggested to be more efficient in depletion of red blood cells (RBC) compared manual phlebotomy the treatment hereditary hemochromatosis (HH), polycythemia vera (PV), and secondary erythrocytosis (SE). The efficiency rate (ER) TE, that is, increase RBC achieved with one TE cycle procedure, can calculated based on estimated volume (BV), preprocedural hematocrit (Hct B ), delta‐hematocrit (ΔHct). In a retrospective evaluation 843 procedures...
Abstract MOTIVATION: RNA Movies is a system for the visualization of secondary structure spaces. Its input script consisting primary and information. From this script, fully automatically generates animated graphical representations. In way, it creates impression an molecule exploring its own two-dimensional space. RESULTS: has been used to generate animations switching in spliced leader Leptomonas collosoma sequential foldings potato spindle tuber viroid transcripts. AVAILABILITY:...
Abstract Objectives There is scarce evidence about the effectiveness of anti‐bleeding measures in hematological outpatients experiencing persistent severe thrombocytopenia. We aim to describe clinical practice and clinicians' considerations on administration prophylactic platelet transfusions tranexamic acid (TXA) with acute leukemia, myelodysplastic syndrome (MDS), or aplastic anemia (AA) Netherlands. Methods conducted an online survey among members Dutch Society for Hematology. Results The...
Maternal alloantibodies directed against fetal red blood cell (RBC) antigens may cause potentially life-threatening haemolytic disease of the fetus and newborn (HDFN). Dutch transfusion guidelines therefore prescribe preventive cEK matching for all (pre-)fertile females. To quantify impact matching, we compared overall antigen-specific cumulative RBC alloimmunisation incidences in females males aged <45 years. Among a multicentre cohort comprised patients who received their first subsequent...
Abstract Background Renal failure and renal replacement therapy (RRT) affect the immune system could therefore modulate red blood cell (RBC) alloimmunization after transfusion. Study Design Methods We performed a nationwide multicenter case‐control study within source population of newly transfused patients between 2005 2015. Using conditional multivariate logistic regression, we compared first‐time transfusion‐induced RBC alloantibody formers (N = 505) with two nonalloimmunized recipients...
Abstract Clonality assessment by the detection of immunoglobulin (IG) gene rearrangements is an important method to determine whether two concurrent or subsequent lymphoid malignancies in one patient are clonally related. Here, we report detailed clonality analysis a with diagnosis B-cell acute lymphoblastic leukemia (B-ALL) followed histiocytic sarcoma (HS), which were able study clonal evolution applying next generation sequencing (NGS) identify IG and mutations. Using sequence information...
Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim this study was to quantify the association between storage PLT and interval next transfusion for different types components, stored up 7 days transfused transfusion-dependent hematooncology patients thrombocytopenia.From a cohort from 10 major Dutch hospitals, were selected whose patterns compatible dependency due hematooncologic disease. Mean mean differences in categories...
Abstract Background and Objectives Donor characteristics have been implicated in transfusion‐related adverse events. Uncertainty remains about whether sex, specifically pregnancy history of the blood donor, could affect patient outcomes. Whether storage duration product be important for outcomes has also investigated, a small detrimental effect fresh products possibility. Here, we hypothesize that red cell donated by ever‐pregnant donors are associated with mortality male patients. Materials...
RNA Movies is a simple, yet powerful visualization tool in likeness to media player application, which enables browse sequential paths through secondary structure landscapes. It can be used visualize structural rearrangement processes of RNA, such as folding pathways and conformational switches, or lists alternative candidates. Besides extending the feature set, retaining improving usability availability web main aim this new version. now supports DCSE RNAStructML input formats besides its...
Standard treatment for naïve hereditary hemochromatosis patients consists of phlebotomy or a personalized erythrocytapheresis. Erythrocytapheresis is more efficient, but infrequently used because perceived costs and specialized equipment being needed. The main aim our study was to develop model that predicts the number initial procedures both methods. This information may help clinician select optimal modality individual patient.We analyzed retrospective data 125 newly diagnosed (C282Y...