In the elucidation of microRNA regulatory network, knowledge potential targets is highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier, P. Steffen, M. Höchsmann and R. Giegerich (2004) RNA , 10 1507–1517] unique in offering a flexible online prediction. Recently, some useful features have been added, among these possibility to disallow G:U base pairs seed region, seed-match speed-up, which accelerates program by factor 8. addition, can now be used as...

Sensitive human data is crucial for biomedical research, enabling faster drug development and better understanding of diseases. The Biohackathon Germany project utilized ELIXIR Europe's services external tools to create Secure Processing Environments, ensuring high protection sensitive while facilitating research across Europe.

A major obstacle in single-cell sequencing is sample contamination with foreign DNA. To guarantee clean genome assemblies and to prevent the introduction of into public databases, considerable quality control efforts are put post-sequencing analysis. Contamination screening generally relies on reference-based methods such as database alignment or marker gene search, which limits set detectable contaminants organisms closely related reference species. As genomic coverage tree life highly...

Abstract Background Today, there is a growing need in bioinformatics to combine available software tools into chains, thus building complex applications from existing single-task tools. To create such workflows, the involved have be able work with each other's data – therefore, common set of well-defined formats needed. Unfortunately, current bioinformatic use great variety heterogeneous formats. Results Acknowledging for formats, Helmholtz Open BioInformatics Technology network (HOBIT)...

Bioinformatics services have been traditionally provided in the form of a web-server that is hosted at institutional infrastructure and serves multiple users. This model, however, not flexible enough to cope with increasing number users, data size, new requirements terms speed availability service. The advent cloud computing suggests service model provides an efficient solution these problems, based on concepts "resources-on-demand" "pay-as-you-go". However, has yet introduced within...

Value-at-risk (VaR) is a common tool applied by market makers to monitor the risk of any trading position. The conventional VaR model assumes frictionless market, which seldom case. 2008 financial crisis exposed inadequacies limits, do not factor in liquidity risk. Various liquidity-adjusted models have been created an attempt correct this anomaly. Our study presents new that incorporates intraday price movements on high-low spreads and adjusts for trade impact measure, k, novel sensitivity...

The academic de.NBI Cloud offers compute resources for life science research in Germany. At the beginning of 2017, started to implement a federated cloud consisting five centers, with aim acting as one resource their users. A introduces multiple challenges, such central access and project management point, unified account across all sites an interchangeable setup federation. In order federation concept, integrated ELIXIR authentication authorization infrastructure system (ELIXIR AAI)...

Bringing heterogeneous devices like industrial machines, home appliances, and wireless sensors into the Web assumes usage of well-defined standards protocols. Our approach combines Service standard for DPWS with embedded system component management OSGi. It implements specifications OSGi Remote Services, as well OASIS Discovery, Eventing, SOAP-over-UDP, DPWS. Furthermore, runtime WSDL generation interpretation is supported, presentation URL feature which automatically provides a web browser...

In this paper conceptions and architectural considerations of the OSAMI project their specializations towards requirements e-health domain by German subproject (OSAMI-D) are described. Along with expected shift healthcare service between stationary ambulatory care, a standardized way integrating medical data acquired at home into IT infrastructure hospitals synchronization workflows have to be implemented. Therefore, OSAMI-D will provide open source components that implement required...

The increasing amount of next-generation sequencing data poses a fundamental challenge on large scale genomic analytics. Existing tools use different distributed computational platforms to scale-out bioinformatics workloads. However, the scalability these is not efficient. Moreover, they have heavy run time overheads when pre-processing amounts data. To address limitations, we developed Sparkhit: framework built top Apache Spark platform.Sparkhit integrates variety analytical methods. It...

e2g is a web-based server which efficiently maps large expressed sequence tag (EST) and cDNA datasets to genomic DNA. It significantly extends the volume of data that can be mapped in reasonable time, makes this improved efficiency available as web service. Our hosts collections EST sequences (e.g. 4.1 million mouse ESTs 1.87 Gb) precomputed indexed structures for efficient comparison. The user upload DNA interest rapidly compare complete collection on server. This delivers mapping interface...

The OSGi Alliance defines an open, modular, and scalable service delivery platform. DPWS specification standardizes the process of consuming exposing Web Services in a lightweight footprint. In our work, we provide solution for mutual integration DPWS. approach adopts mechanisms distributed object systems. It employs OSGi-based proxies skeletons.

In the context of automated technical management distributed ambient-assisted-living healthcare systems, we employ high-level policies which describe abstract requirements system from use cases point view. At runtime, an efficient low-footprint is used executes low-level rules event-condition-action type. The represent policies. They monitor status variables software components and change settings their configuration in order to enforce requirements. We report on automated, tool-supported...

The purpose of this study was to investigate whether there are any significant abnormal returns around the public announcement earnings and establish efficient capital market hypothesis applies small ALT-X market. population interest all companies that were listed on JSE-ALTX, announced annual earnings, from1 January 2009 31 December 2009. method calculating expected CAPM. empirical evidence showed is substantial negative share price reaction announcements stock also weak-form efficiency.

RNA Movies is a simple, yet powerful visualization tool in likeness to media player application, which enables browse sequential paths through secondary structure landscapes. It can be used visualize structural rearrangement processes of RNA, such as folding pathways and conformational switches, or lists alternative candidates. Besides extending the feature set, retaining improving usability availability web main aim this new version. now supports DCSE RNAStructML input formats besides its...

The presented policy-based management system supports autonomous control and adaptation of a distributed according to changing conditions requirements by means event-condition-action (ECA) rules. Furthermore, it policy-aware application programming. Application components can request evaluations policy expressions decisions in order govern their behavior depending on global state environment conditions. That rich functionality has be provided very efficiently since the consists...

The demographic change and the cost pressure in healthcare sector drive need for efficient secure medical homecare solutions which apply people who are elderly or anastasis. As complexity of such systems is rising, there a common foundation components can be reused to lower implementation effort systems. European ITEA2 OSAmI research project targets basic basic, widely applicable service-oriented component platform. German OSAmI-D subproject develops construction kit based on platform with...

Many investors, practitioners and academicians are interested in knowing the factors that pertinent influencing share prices. Growth is generally among important equity value drivers. Sustainable growth rate (SGR) for assessing shortcomings of company it captures creation probability a company. Therefore, aim this study was to determine relationship between sustainable price movements companies listed on Johannesburg Securities Exchange from 2004 2014. For purpose, data 93 JSE obtained...

Abstract Background Post-translational modifications (PTM) of amino acid (AA) side chains in peptides control protein structure and functionality. PTMs depend on the specific AA characteristics. The reactivity cysteine thiol-based are unique among all proteinaceous AA. This pipeline aims to ease identification conserved polypeptides or families based phylogenetic occurrence plant kingdom. tool is customizable include any species. degree conservation taken as indicator for structural...

Supported by an automated runtime management system even critical applications, like healthcare can be build upon the interaction with ambient services. They are provided mobile resource-constrained devices and subject to frequently changing environmental conditions exceptions. The has ensure stable bindings between interacting services thus it provide monitoring control functionality necessary for binding reconfiguration adaption. Furthermore, due resource restriction of like, example...

Intelligent connected devices become a more vital part of our lives. In contrast to prior years, today embedded systems and are loosely coupled cooperate with each other according changing objectives. Following the service-oriented architectural style, approach so called device-based service emerges. The challenge is build manage these in reliable, secure, efficient manner. New innovative solutions needed regarding problems interoperability, maintainability, as well automated configuration...