A5048894874- Chromatin Remodeling and Cancer
- Nuclear Receptors and Signaling
- S100 Proteins and Annexins
- Histone Deacetylase Inhibitors Research
- Orthopedic Surgery and Rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Kruppel-like factors research
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Tendon Structure and Treatment
- Voice and Speech Disorders
- Lower Extremity Biomechanics and Pathologies
- Cancer Mechanisms and Therapy
- Foot and Ankle Surgery
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Pleural and Pulmonary Diseases
- Peripheral Nerve Disorders
- Musculoskeletal synovial abnormalities and treatments
- Bone Metabolism and Diseases
- Educational Robotics and Engineering
- Body Composition Measurement Techniques
- Myasthenia Gravis and Thymoma
Okayama University
2016-2024
Kyoto Prefectural University of Medicine
2014-2023
Japan Community Healthcare Organization
2020-2023
Kobe Central Hospital
2020-2023
Koshigaya Municipal Hospital
2018
Matsushita Memorial Hospital
2016
We investigated the effects of adipose-derived extract (AE) on cultured chondrocytes and in vivo cartilage destruction. AE was prepared from human adipose tissues using a nonenzymatic approach. Cultured were stimulated with interleukin-1 beta (IL-1β) or without different concentrations AE. The co-treatment intracellular signaling pathways their downstream gene protein expressions examined real-time PCR, Western blotting, immunofluorescence staining. Rat inguinal intra-articularly delivered...
Abstract Background Patients with high‐risk neuroblastoma have a poor prognosis; new therapeutic agents are therefore required. We investigated the antitumor effects of OBP‐801, novel histone deacetylase inhibitor, its underlying mechanism, and potential as agent for patients neuroblastoma. Methods The study included five human cell lines: IMR32, GOTO, KP‐N‐RTBM, SK‐N‐AS, SH‐SY5Y. proliferation, cycle status, protein expression patterns, apoptosis in cells after OBP‐801 treatment vitro ....
We investigated the long-term clinical results of total elbow arthroplasty (TEA) by cementless fixation alumina ceramic unlinked prostheses (J-alumina elbows: JACE) for reconstruction joints with rheumatoid arthritis (RA). Seventeen elbows in 17 patients (aged 44-72 years, average 54.8) replaced JACE TEA without bone cement were investigated. The follow-up period was 10.7 (range, 1.0-19.3) years. Clinical conditions each before and after surgery assessed according to Mayo Elbow Performance...
Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily B member 1 (SMARCB1)/integrase interactor (INI1) gene only common genetic feature in rhabdoid tumors. Loss SMARCB1 function results downregulation several suppressor genes including p16, p21, and NOXA The novel histone deacetylase inhibitor, OBP-801, induces p21 has shown efficacy against various cancers. In our study, OBP-801...
We investigated the expression and localization of receptor activator nuclear factor κB ligand (RANKL) in cartilage from patients with rheumatoid arthritis (RA) relevance to degeneration. also examined role exogenous lymphotoxin (LT)-α on RANKL human chondrocytes its effect vitro osteoclast differentiation. Cartilage synovial fluid samples were obtained 45 undergoing total joint replacement surgery or puncture, including 24 osteoarthritis (OA) 21 RA. articular was by immunohistochemistry....
Swyer-James syndrome is a rare that occurs as result of repeated bronchiolitis and pneumonitis in childhood. Most cases are asymptomatic, subsequent diagnosis may not occur until adulthood. We present the case 7-year-old female with syndrome, which was initially diagnosed treated asthma. The patient developed respiratory distress atelectasis were biphasic cuirass ventilation. This suggests should be concern patients chronic cough wheezing, highlights importance taking careful history...
Seronegative myasthenia gravis (MG) is a generalized form of MG that diagnosed on the basis clinical symptoms, electrophysiological testing, and pharmacological responses, in absence seropositive status for anti-acetylcholine receptor (AChR) antibodies. Generalized seronegative anti-AChR, anti-muscle-specific kinase (MuSK), anti-low density lipoprotein related protein 4 (Lrp4) antibodies known as triple-seronegative MG. We here describe case an 8-year-old boy. His first symptom was...
We studied phrenic nerve conduction times in 90 nerves of 45 normal subjects. The was stimulated at the posterior border sternomastoid muscle supraclavicular fossa, just above clavicle, with bipolar surface electrodes. For recording, positive and negative electrodes were placed on xiphoid process eighth intercostal bone-cartilage transition, respectively. both right left sides to determine whether there any difference between two sides. mean onset latency (± SD) compound action potentials...
We retrospectively investigated the mid-term outcomes of arthroplasty using AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients rheumatoid arthritis (RA). This study involved 36 thumbs 33 RA a mean follow-up period 5.1 years (range, 2.0-13.3). Postoperatively, extension was significantly increased and flexion decreased (p<0.001, p<0.001, respectively), resulting arc range motion (ROM) shifting direction after surgery. Implant fracture...
肩関節の運動では，肩甲上腕関節，肩鎖関節，胸鎖関節，肩甲胸郭関節などの関節および肩峰下滑液包などが関与している．正常の可動域の獲得には肩甲上腕関節のみならず，肩甲胸郭関節，および脊柱の動きが重要である．肩甲上腕関節を動かす筋群としては，内在筋として肩腱板を形成する棘上筋，棘下筋，小円筋，肩甲下筋があり，外在筋としては三角筋，大胸筋，広背筋，大円筋などがある．肩関節のリハビリテーション（以下，リハ）の基本として，疼痛管理，肩甲上腕関節や肩甲胸郭関節の自動・他動運動の行い方，肩腱板の筋力エクササイズについて記載した．また，日常よく遭遇する肩関節疾患について，疾患の概要とリハについても記載した
<h3>Background</h3> Patient self-administered questionnaires remove the possibility of observer bias, and are important instruments for assessment clinical outcome. The patient-rated elbow evaluation (PREE) is a joint-specific, questionnaires. <h3>Objectives</h3> We aimed to investigate correlation between Japanese version PREE (PREE-J) other parameters in rheumatoid arthritis (RA) patients before after total arthroplasty (TEA). <h3>Methods</h3> Thirty-five elbows 32 RA (M/F: 3/29) were...
<h3>Background</h3> Treatment of rheumatoid arthritis (RA) has improved over the past decade with modification treatment strategy and recent application biologic agents (Bio). It been revealed that by Bio achieved not only improvement clinical symptom, but also inhibition progression joint destruction in small joints hand foot. However, there are little evidences large Bio. ARASHI score, is composed Status Score (ASS) Change (ACS), have newly developed to evaluate as well...
<h3>Background</h3> The goal of treat to target (T2T) is the clinical remission in patients with early disease, but it difficult achieve functional remission. Although patient9s subjective evaluation important for assessment postoperative functions rheumatoid arthritis (RA) patients, there are few reports examined patients-reported after upper extremity surgery RA. <h3>Objectives</h3> Between 2011 and 2014, 158 RA underwent surgical treatment on extremities, all were available detailed...
<h3>Background</h3> Recent effective treatment with disease-modifying anti-rheumatic drugs (DMARDs) including biologic DMARDs (bDMARDs) improved the disease control of patients rheumatoid arthritis (RA), and change body image might influenced surgical indication. Body assessment tool (BIAT) has been reported to be a reliable valid tool<sup>1)</sup>. Patients RA had worse than individuals without RA<sup>2)</sup>, however, there are no evidence showed who requires intervention....
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<div>Abstract<p>Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily B member 1 (<i>SMARCB1</i>)/integrase interactor (<i>INI1</i>) gene only common genetic feature in rhabdoid tumors. Loss <i>SMARCB1</i> function results downregulation several suppressor genes including <i>p16, p21</i>, and <i>NOXA</i>. The...
<div>Abstract<p>Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily B member 1 (<i>SMARCB1</i>)/integrase interactor (<i>INI1</i>) gene only common genetic feature in rhabdoid tumors. Loss <i>SMARCB1</i> function results downregulation several suppressor genes including <i>p16, p21</i>, and <i>NOXA</i>. The...