A5100650737- SARS-CoV-2 detection and testing
- Clostridium difficile and Clostridium perfringens research
- Dialysis and Renal Disease Management
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- Biosensors and Analytical Detection
- Genomics and Chromatin Dynamics
- SARS-CoV-2 and COVID-19 Research
- Esophageal and GI Pathology
- Hedgehog Signaling Pathway Studies
- Appendicitis Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Diabetes Management and Research
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraperitoneal and Appendiceal Malignancies
- Microscopic Colitis
- Hepatitis C virus research
- Venous Thromboembolism Diagnosis and Management
- Sleep and Wakefulness Research
- Genomic variations and chromosomal abnormalities
- Anesthesia and Neurotoxicity Research
- Muscle and Compartmental Disorders
University of Calgary
2020-2025
Alberta Health Services
2020-2024
The University of Texas Southwestern Medical Center
2024
Mount Sinai Hospital
2023
The University of Texas at Austin
2018-2022
Stanford Medicine
2021
University Hospitals of Cleveland
2020
Duke University Hospital
2019
Duke Medical Center
2019
Icahn School of Medicine at Mount Sinai
2017-2018
OBJECTIVES Pediatric hospitalization rates are used as a marker of coronavirus disease 2019 (COVID-19) severity in children but may be inflated by the detection mild or asymptomatic infection via universal screening. We aimed to classify COVID-19 hospitalizations using an existing and novel approach assess interrater reliability both approaches. METHODS This retrospective cohort study characterized illness likelihood severe acute respiratory syndrome 2 (SARS-CoV-2) cause pediatric patients...
Vancomycin resistant Enterococcus (VRE) is an important cause of healthcare associated infections. We adapted wastewater based surveillance as a tool to longitudinally monitor VRE in hospitals through the detection vancomycin resistance genes vanA and vanB. Wastewater from four tertiary care (three adult one pediatric, totaling >2300 inpatient beds) all three municipal treatment plants (WWTP) Calgary, Canada (1.4 million) was sampled weekly (March September 2022) every other week...
Background Prophylaxis for venous thromboembolism (VTE) in head injured patients has avoided heparin products because of concern exacerbating intracranial bleeding. The purpose this study was to evaluate the safety unfractionated (UFH) VTE prophylaxis after traumatic brain injury. Methods We retrospectively evaluated early use UFH sustaining a severe closed injury (Abbreviated Injury Scale score > 3) from January 1, 2000, through December 31, 2000. Two groups were formed on basis timing...
Patients with CKD exhibit significant within-patient hemoglobin (Hb) level variability, especially the use of erythropoiesis stimulating agents (ESAs) and iron. Analyses dialysis cohorts in United States produced conflicting results regarding association Hb variability patient outcomes. Here, we determined 5037 European hemodialysis (HD) patients treated over 2 years to identify predictors high evaluate its all-cause cardiovascular disease (CVD) mortality. We assessed various methods using...
Abstract The Hedgehog (HH) pathway regulates a spectrum of developmental processes through the transcriptional mediation GLI proteins. repressors control tissue patterning by preventing sub-threshold activation HH target genes, presumably even before induction, while lack repression activates most targets. Despite being central to regulation, it is unknown when first becomes established in HH-responsive tissues. Here, we investigate whether GLI3 prevents precocious gene expression during...
Wastewater-based SARS-CoV-2 surveillance enables unbiased and comprehensive monitoring of defined sewersheds. We performed real-time hospital wastewater that differentiated Delta Omicron variants within total SARS-CoV-2-RNA, enabling correlation to COVID-19 cases from three tertiary-care facilities with >2100 inpatient beds in Calgary, Canada. RNA was extracted between August/2021 January/2022, quantified using RT-qPCR. Assays targeting R203M R203K/G204R established the proportional...
Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker undergoing clinical trials as prolonged-duration local anesthetic. Rat sciatic block and intravenous infusion models were used to assess efficacy systemic toxicities for NeoSTX in saline (NeoSTX-Saline), bupivacaine (Bup), their combination (NeoSTX-Bup). Exploratory studies evaluated the effects of addition epinephrine NeoSTX-Bup (NeoSTX-Bup-Epi).Rats received percutaneous blocks with escalating doses NeoSTX-Saline or NeoSTX-Bup....
<i>Background/Aims:</i> ARO, an observational study of hemodialysis (HD) patients in Europe, aims to enhance our understanding patient characteristics and practice patterns improve outcome. <i>Methods:</i> HD (n = 8,963) from 134 Fresenius Medical Care facilities treated between 2005 2006 were randomly selected 9 European countries (Czech Republic, France, Hungary, Italy, Poland, Portugal, Spain, Slovak Republic Slovenia) Turkey. Information was captured on...
ABSTRACT GSK2248761 is a novel, once-daily (QD), next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) with activity against efavirenz-resistant strains. Two phase I/IIa, double-blind, randomized, placebo-controlled studies investigated the antiviral activity, safety, and pharmacokinetics (PK) of several doses monotherapy in treatment-naive HIV-infected subjects. In initial study, 10 subjects (8 active 2 placebo) per dose received sequentially descending regimens 800, 400,...
Introduction:We present a case of cecal bascule, rare type volvulus, as complication laparoscopic ventral hernia repair.Case Description:A 73-y-old male with underwent an uneventful elective repair. He developed acute abdomen on postoperative day 6, and imaging demonstrated bascule. Exploratory laparotomy revealed bascule ischemic perforated cecum, right hemicolectomy was performed.Discussion:Laparoscopic tension-free repairs have become more common, especially for obese patients. We discuss...
Cellular oxygen consumption and lactate production rates have been measured in both placental myometrial cells to study obstetrics-related disease states such as preeclampsia. Platelet metabolic alterations indicate systemic bioenergetic changes that can be useful biomarkers. We tested the hypothesis platelet mitochondria display functional Platelets were harvested from women third trimester of either a healthy, non-preeclamptic or preeclamptic pregnancy, non-pregnant women. Using Seahorse...
Aspergillus endocarditis is a rare infection and reported mainly in immunocompromised hosts. We report case of mitral valve aspergillus with ventricular myocardial invasion, cerebral vasculitis intracranial fungal aneurysm formation patient hemophagocytic lymphohistiocytosis (HLH). This illustrates the importance prompt investigation treatment masses seen on an echocardiogram for infections such as patients.
Abstract Refractory cancer represents a challenge for oncologists in providing treatment options without excessive toxicity and has led to the investigation of immune mechanisms. Immune checkpoint inhibitors (ICIs) directly interfere with tumor cells' ability evade innate adaptive system by targeting specific proteins such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1), protein-ligand 1 (PD-L1), which are involved negative regulators T-cell...
ObjectivesDapagliflozin is an inhibitor of the human sodium-glucose co-transporter 2 (SGLT2) that has been shown to improve glycaemic control in patients with type diabetes mellitus (T2DM). This study aimed evaluate characteristics and treatment patterns dapagliflozin users comparison other anti-diabetic (AD) treatments Germany.MethodsData from T2DM initiating at least one prescription for or AD therapy between November 2012 April 2014 were collected IMS German Disease Analyzer...
Clostridioides difficile infection (CDI) is an opportunistic disease that lacks a gold-standard test. Nucleic acid amplification tests such as real-time polymerase chain reaction (PCR) demonstrate excellent limit of detection (LOD), whereas antigenic methods are able to detect protein toxin. Latent class analysis (LCA) provides unbiased statistical approach resolving true disease.A cross-sectional study was conducted in patients with suspected CDI (N = 96). Four commercial PCR tests, toxin...
Abstract We analyzed invasive group A streptococcal puerperal sepsis cases in a large health zone Alberta, Canada between 2013 and 2022. Of the 21 cases, 85.7% were adjudicated as hospital/delivery-acquired, with 2 clusters having identical isolates found through whole genome sequencing. implemented policy interventions across Alberta aimed at preventing future infections.
Objective The objective of this study was to analyze the impact Area Deprivation Index (ADI) on disease activity and cardiovascular comorbidity in rheumatoid arthritis (RA). Methods A retrospective analysis adult patients with RA conducted highlight differences academic safety net hospital clinics. Demographics, medication history, patient portal engagement, primary care presence, emergency or inpatient visits, functional scores, Charlson Comorbidity (CCI), (CVD) presence were captured. ADI...
Abstract Background Management of suspected Clostridioides difficile infection (CDI) in the hospital setting typically results patient isolation, laboratory testing, control, and presumptive treatment. We investigated whether implementation rapid near-patient testing (NPT) reduced isolation time, length stay (LOS), antibiotic usage, cost. Methods A 2-period pragmatic cluster randomized crossover trial was conducted. Thirty-nine wards were into 2 study arms. The primary outcome measure effect...