A5055231179- Intraperitoneal and Appendiceal Malignancies
- Health Systems, Economic Evaluations, Quality of Life
- Appendicitis Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Gallbladder and Bile Duct Disorders
- Metastasis and carcinoma case studies
- Statistical Methods in Clinical Trials
- Minimally Invasive Surgical Techniques
- Advanced Causal Inference Techniques
- Innovations in Medical Education
- Plant Disease Resistance and Genetics
- Healthcare Policy and Management
- Economic Theory and Policy
- Pharmaceutical industry and healthcare
- Diversity and Career in Medicine
- Neuroendocrine Tumor Research Advances
- Hernia repair and management
- Gastrointestinal Tumor Research and Treatment
- Musculoskeletal Disorders and Rehabilitation
Rabin Medical Center
2015-2024
Tel Aviv University
2019-2024
Harvard University
2005-2024
Brigham and Women's Hospital
2000-2024
Misgav Ladach
2024
SUNY Upstate Medical University
2024
Emory University
2024
Durham VA Health Care System
2024
University of North Carolina at Chapel Hill
2024
University of Pittsburgh
2024
Recently, the Food and Drug Administration (FDA) issued an advisory stating that atypical antipsychotic medications increase mortality among elderly patients. However, did not apply to conventional medications; risk of death with these older agents is known.We conducted a retrospective cohort study involving 22,890 patients 65 years age or who had drug insurance benefits in Pennsylvania began receiving medication between 1994 2003. Analyses rates Cox proportional-hazards models were used...
Postmarketing observational studies of the safety and effectiveness prescription medications are critically important but fraught with methodological problems. The data sources available for such research often lack information on indications other confounders drug exposure under study. Instrumental variable methods have been proposed as a potential approach to control confounding by indication in nonexperimental treatment effects; however, good instruments hard find.We propose an instrument...
<h3>Background</h3> Long-term compliance with pharmacologic treatments for many asymptomatic conditions may be suboptimal, but little is known about medications used osteoporosis. This study was undertaken to assess the level and determinants of drugs prescribed <h3>Methods</h3> retrospective cohort pharmacy claims data from US Medicare filled prescriptions a state pharmaceutical benefits program. We included persons 65 years or older who initiated use medication osteoporosis (alendronate...
<h3>Background</h3> Antibiotic misuse is common and costly may promote antibiotic resistance. We tested the efficacy of a targeted one-on-one educational program ("academic detailing") designed to improve appropriateness broad-spectrum use. <h3>Methods</h3> A randomized controlled trial was conducted in large US teaching hospital. During an 18-week study period, 17 general medical, oncology, cardiology services either received academic detailing or did not. The intervention prompted by order...
There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers diagnostic prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung patients before surgery cohort 1,358 high-risk subjects. Serum levels long pentraxin 3 (PTX3) determined by high-sensitivity ELISA. PTX3 immunostaining was evaluated immunohistochemistry tissue. the population not...
This qualitative study uses a focus group approach to determine factors influencing adherence osteoporosis medications among older adults. Thirty-two patients aged 65 85 years from the Greater Boston area who were prescribed an medication, 11 general medicine physicians, and 1 nurse practitioner recruited Boston-based hospitals affiliated with large health care system.
Background Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is effective in select patients with peritoneal carcinomatosis (PC). Signet ring cell (SRC) pathology associated poor prognosis. The role of CRS/HIPEC this population unclear. Methods Patients diagnosed PC due to appendiceal (AC), colorectal (CRC), gastric cancer (GC) undergoing 2007‐2016 were included. Results A total 268 referred for CRS/HIPEC. Of the 204 who underwent complete CRS/HIPEC, 101 (49.5%)...
To prospectively study the incidence of and risk factors for home health care (HHC) use in a cohort elderly medical surgical patients discharged from acute care. Although HHC is commonly received by this group, its predictors have not been well studied.Prospective study.Medical wards at university teaching hospital, followed 23 Medicare-certified agencies catchment area.226 aged 70 years older immediately after discharge care.HHC initiated within 14 days hospital discharge, measured direct...
In Brief Objective: This report describes the first cohort study comparing pure transvaginal appendectomies (TVAs) to traditional 3-port laparoscopic (LAs). Methods: Between August 2008 and 2010, 42 patients were offered a TVA. Patients who did not wish undergo TVA underwent LA served as control group. Demographic data, operative time, length of stay, patient controlled analgesia (PCA) 12-hour-morphine utilization, complications, return normal activity, work recorded. Results: Eighteen 40...
Objective To evaluate the cost-effectiveness of different strategies for preventing corticosteroid-induced osteoporosis. Methods Simulated cohorts postmenopausal women with rheumatoid arthritis (RA) starting corticosteroid treatment were examined. A Markov decision analysis model was developed to compare management strategies, including watchful waiting, screen and treat, empirical treatment. Treatment thresholds treat strategy varied from bone mineral density (BMD) T scores <−1.0 BMD <−4.0....
The FDA approves many devices on the basis of similarity to precursors, possibly encouraging development slightly improved, higher-cost devices. A modeling approach can illuminate interplay among efficacy and durability, patient characteristics, costs, outcomes.