A5065832482- Ferrocene Chemistry and Applications
- Metal complexes synthesis and properties
- Organometallic Compounds Synthesis and Characterization
- Magnetism in coordination complexes
- Biotin and Related Studies
- Synthesis of Tetrazole Derivatives
- Lanthanide and Transition Metal Complexes
Western Sydney University
2017-2023
Camden and Campbelltown Hospitals
2020
Platinum(IV) prodrugs of the [Pt(P
Four platinum(IV) prodrugs incorporating a biotin moiety to selectively target cancer cells were synthesised, characterised, and their biological activity assessed. All complexes exhibited exceptional in vitro cytotoxicity against panel of cell lines, with [Pt(5,6-dimethyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)(biotin)(hydroxido)](NO3)2, (2) exhibiting the lowest GI50 4 nM prostate Du145 line. Each complex displayed significantly enhanced compared cisplatin, 2 being 1000-fold more...
A novel platinum(II) complex 47OMESS(II) and its platinum(IV) derivative 47OMESS(IV) were synthesized characterized. Cytotoxicity studies against mesenchymal cells (MCs) lung (A549), breast (MDA-MB-231), melanoma (A375) cancer demonstrated 7–20-fold superior activity for both complexes relative to cisplatin. Remarkably, 17–22-fold greater selectivity toward the cancerous compared non-cancerous MCs. Western blot analysis on A549 showed involvement of intrinsic apoptotic pathway. Cellular...