A5044720349- Gene expression and cancer classification
- Alzheimer's disease research and treatments
- Single-cell and spatial transcriptomics
- Lipid Membrane Structure and Behavior
- Molecular Biology Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Supramolecular Self-Assembly in Materials
- Prion Diseases and Protein Misfolding
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Genomics and Phylogenetic Studies
- Origins and Evolution of Life
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Neural dynamics and brain function
- Mosquito-borne diseases and control
- RNA modifications and cancer
- Cellular transport and secretion
- Microbial Metabolic Engineering and Bioproduction
- Neural Networks and Applications
- Advanced Memory and Neural Computing
- Neuroscience and Neuropharmacology Research
- Fish biology, ecology, and behavior
- Cholesterol and Lipid Metabolism
- Gene Regulatory Network Analysis
University of Cambridge
2018-2022
Casa di Cura San Michele
2018
Google (United States)
2018
Scuola Normale Superiore
2015-2018
A progressive loss of protein homeostasis is characteristic aging and a driver neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics proteomics. We detected reduction correlation between mRNA, mainly due to post-transcriptional mechanisms that account for over 40% age-regulated proteins. These changes cause stoichiometry several complexes, including...
The molecular origins of Alzheimer's disease are associated with the aggregation amyloid-β peptide (Aβ). This process is controlled by a complex cellular homeostasis system, which involves variety components, including proteins, metabolites, and lipids. It has been shown in particular that certain components lipid membranes can speed up Aβ aggregation. observation prompts question whether there protective mechanisms to counterbalance this effect. Here, address issue, we investigate role...
The aggregation of the amyloid β (Aβ) peptide is one molecular hallmarks Alzheimer's disease (AD). Although Aβ deposits have mostly been observed extracellularly, various studies also reported presence intracellular assemblies. Because these aggregates might play a role in onset and progression AD, it important to investigate their possible origins at different locations cell along secretory pathway precursor protein, from which derived by proteolytic cleavage. Senile plaques found AD are...
Summary A progressive loss of protein homeostasis is characteristic aging and a driver neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics proteomics. We detected reduction correlation between mRNA, mainly due to post-transcriptional mechanisms that account for over 40% age-regulated proteins. These changes cause stoichiometry several complexes, including...
The regulation of mRNA translation at the level synapse is believed to be fundamental in memory and learning cellular level. family cytoplasmic polyadenylation element binding (CPEB) proteins emerged as an important RNA-binding protein during development adult neurons. Drosophila Orb2 (homologue mouse CPEB3 neural isoform Aplysia CPEB) has been found involved plasticity-dependent mRNAs associated with long-term memory. presents two main isoforms, Orb2A Orb2B, which form activity-induced...
Abstract The regulation of mRNA translation at synaptic level is believed to be fundamental in memory and learning cellular level. A family RNA binding proteins (RBPs) which emerged important during development adult neurons the one Cytoplasmic Polyadenylation Element Binding (CPEBs). Drosophila Orb2 (homolog vertebrate CPEB2 protein neural isoform Aplysia CPEB) has been found involved plasticity-dependent mRNAs associated Long Term Memory (LTM). presents two main isoforms, Orb2A Orb2B, form...
ABSTRACT The aggregation of the amyloid β peptide (Aβ) is one major molecular hallmarks Alzheimer’s disease. Although Aβ deposits have been mostly observed extracellularly, various studies reported presence also intracellular assemblies. Because these aggregates might play a role in onset and progression disease, it important to investigate their possible origins at different locations cell along secretory pathway precursor protein (APP), from which derived by proteolytic cleavage. Since...