A5016919857- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Acute Ischemic Stroke Management
- vaccines and immunoinformatics approaches
- Cardiac Arrest and Resuscitation
- Immunotherapy and Immune Responses
- ECG Monitoring and Analysis
- Intracranial Aneurysms: Treatment and Complications
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Solid State Laser Technologies
- Peripheral Nerve Disorders
- Construction Project Management and Performance
- Radiation Dose and Imaging
- Monoclonal and Polyclonal Antibodies Research
- Urinary Bladder and Prostate Research
- Neurofibromatosis and Schwannoma Cases
- Infectious Aortic and Vascular Conditions
- Oropharyngeal Anatomy and Pathologies
Beth Israel Deaconess Medical Center
2023-2025
Harvard University
2023-2025
Georgetown University
2021-2024
Georgetown University Medical Center
2021
Background: Chronic kidney disease (CKD) increases morbidity and mortality in most vascular procedures. However, a binary classification of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 , which is often used both modeling clinical trials, may not be optimal for predicting outcomes. Objective: Determine the eGFR cutoff use risk stratification prediction models. Methods: Vascular Quality Initiative (VQI) data non-emergent, first-time OAR, EVAR, TEVAR, CEA, CAS, PVI, Supra-...
We developed an epitope selection method for the design of MHC targeting peptide vaccines. The utilizes predictions several clinical checkpoint filters, including binding affinity, immunogenicity, antigenicity, half-life, toxicity, IFNγ release, and instability. accuracy prediction tools these filter variables was confirmed using experimental data obtained from Immune Epitope Database (IEDB). also a graphical user interface computational tool called 'PCOptim' to assess success filtration...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has challenged public health at an unprecedented scale which led to a dramatic loss human life worldwide. To design protective vaccine against SARS-CoV-2, it is necessary understand SARS-CoV-2 specific epitopes can elicit T cell response and provide protection across broad population. In this study, PLpro RdRp, two immunogenic non-structural proteins from immunodominant gene region ORF1ab,...
Objectives Despite the advantages that fenestrated endovascular aortic repair (FEVAR) has over open it is accompanied by consequence of radiation exposure, which can result in long-term complications for both patient and surgical staff. Fiber Optic RealShape (FORS) technology a novel advancement utilizes emitted light from fiber optic wire enables surgeon to cannulate vessels real time without live fluoroscopy. This been implemented at select centers study its effectiveness cannulation...
Abstract The current COVID-19 pandemic continues to spread and devastate in the absence of effective treatments, warranting global concern action. Despite progress vaccine development, rise novel, increasingly infectious SARS-CoV-2 variants makes it clear that our response virus must continue evolve along with it. use immunoinformatics provides an opportunity rapidly efficiently expand tools at disposal combat prepare for future outbreaks through epitope-based design. In this study, we...
Outcomes following redo-CEA (rCEA) have been shown to be worse than those after primary CEA (pCEA). Additional research has that outcomes are better with TCAR for restenosis compared rCEA and tfCAS; however, some patients not eligible or tfCAS. Given the increasing utilization of endovascular techniques, this study aims evaluate changes in vs pCEA before approval by FDA 2015. All between 2003 2023 who underwent VQI were included categorized as rCEA. Cochrane-Armitage trend testing was used...
The outcomes of carotid revascularization in patients with prior artery stenting remain understudied. In addition, research has not reported the after transcarotid previous stenting. Using Vascular Quality Initiative data from 2016 to 2023, we identified who underwent TCAR, tfCAS, or CEA following ipsilateral We included covariates such as age, race, sex, BMI, comorbidities (hypertension, diabetes, CAD, CABG/PCI, CHF, renal dysfunction, smoking, COPD, anemia), symptom status, urgency,...
Respiratory complications after thoracic endovascular aortic repair (TEVAR) remain poorly characterized due to the lack of comprehensive studies identify individuals prone these complications. This study aims determine incidence, factors associated with, and outcomes respiratory TEVAR. We identified Vascular Quality Initiative patients undergoing TEVAR isolated zones 0-5 from 2010 2023 for non-traumatic pathologies. After determining incidence postoperative complications, we assessed...