A5004385077- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Neurotransmitter Receptor Influence on Behavior
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Infectious Aortic and Vascular Conditions
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Trauma Management and Diagnosis
- Receptor Mechanisms and Signaling
- Radiation Detection and Scintillator Technologies
- Trauma and Emergency Care Studies
- Diversity and Career in Medicine
- Atomic and Molecular Physics
- Laser-induced spectroscopy and plasma
- Advanced MRI Techniques and Applications
University of Massachusetts Chan Medical School
2020-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
UMass Memorial Medical Center
2020-2023
UMass Memorial Health Care
2022-2023
Memorial Medical Center
2023
University of Massachusetts Amherst
2023
University of New Orleans
2023
Townsville Hospital
2023
Wellesley College
2023
Massachusetts General Hospital
2022
Dysfunction of monoamine uptake mechanisms has been implicated in the pathogenesis alcohol dependence. The authors explored whether serotonergic dysfunction is associated with anxiety and depression, which increase risk relapse alcoholics.The availability serotonin dopamine transporters 22 male alcoholics 13 healthy volunteers was measured use [123I] beta-CIT single photon emission computed tomography, psychopathological correlates were assessed.A significant reduction (a mean about 30%)...
Tourette syndrome, a chronic tic disorder with autosomal dominant inheritance, exhibits considerable phenotypic variability even within monozygotic twin pairs. The origins of this remain unclear. Recent findings have implicated the caudate nucleus as locus pathology, and pharmacological evidence supports dopaminergic involvement. Within twins discordant for syndrome severity, differences in D2 dopamine receptor binding head predicted severity (r = 0.99); relation was not observed putamen....
Journal Article Gender Differences in the Normal Lateralization of Supratemporal Cortex: MRI Surface-rendering Morphometry Heschl's Gyrus and Planum Temporale Get access Jennifer J. Kulynych, Kulynych Clinical Brain Disorders Branch, NIMH Neuroscience Center at St. Elizabeths, Intramural Research Program, National Institute Mental HealthWashington, DC 20032 Search for other works by this author on: Oxford Academic PubMed Google Scholar Katalin Vladar, Vladar Douglas W. Jones, Jones Daniel R....
It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response ("noise") is thought to result from impaired phase resetting stimulus-induced dynamic changes ongoing rhythmic oscillations (field potentials) generated the apical dendrites pyramidal neurons. In present study, authors explored whether this particular abnormality predicts working memory performance...
Enlarged ventricular size and/or asymmetry have been found markers for psychiatric illness, including schizophrenia. However, this morphometric feature is non-specific and occurs in many other brain diseases, its variability healthy controls not sufficiently understood. We studied shape 3D MRI (N=20) of monozygotic (N=5) dizygotic twin pairs. Left right lateral, third fourth ventricles were segmented from high-resolution T1w SPGR using supervised classification connectivity. Surfaces binary...
Postmortem studies have implicated the central muscarinic acetylcholine system in schizophrenia. However, receptor availability has not previously been studied vivo. Using [I-123]iodoquinuclidinyl benzilate ([(123)I]IQNB) single photon emission computed tomography (SPECT), authors sought to compare vivo unmedicated patients with schizophrenia and normal subjects.Twelve medication-free underwent an [(123)I]IQNB SPECT scan during approximate-equilibrium conditions. A group of 10 age-...
To examine the use of surgical procedures for Crohn's disease since introduction infliximab.Prior studies have shown that overall rate surgery has not changed significantly infliximab, an immunomodulator considered particularly effective in treating fistulas. How infliximab affected individual rates specific types procedures, intestinal fistulas, is unknown.We used Nationwide Inpatient Sample to identify all hospital admissions each year from 1993 through 2004. Cases and relevant...
Studies on brain serotonin metabolism in human and nonhuman primates have indicated that dysfunction of transmission may play a role the biological vulnerability to dependence alcohol. Among young men, low sensitivity alcohol intoxication predicts subsequent abuse dependence.The authors used single photon emission computed tomography radioligand [(I)123]beta-CIT ([(I)123]methyl 3beta-(4-iodophenyl) tropane-2-carboxylate) measure availability transporters 11 male rhesus monkeys, monkeys were...
The structural variability of lateral ventricles is poorly understood notwithstanding that enlarged size has been identified as an unspecific marker for psychiatric illness, including schizophrenia. This paper explores the effects heritability and genetic risk schizophrenia reflected in ventricular structure. We examined shape MRI studies monozygotic (MZ) twin pairs discordant (DS), healthy MZ pairs, dizygotic nonrelated subject pairs. Heritability effect due to disease were analyzed two...
Introduction: Common femoral endarterectomy (CFE) has historically been the preferred treatment for atherosclerotic lesions involving common artery. The objectives of this study are to delineate safety open procedure in endovascular era, establish contemporary benchmarks morbidity and mortality after CFE, identify subgroup patients at increased risk postoperative adverse events. Methods: Patients undergoing elective CFE 2007 2010 National Surgical Quality Improvement Project database were...
We assessed the suitability of event-related potential frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies schizophrenia. applied a principal component analysis approach based on notion that abnormalities siblings schizophrenic patients may involve widespread network relatively weak cortical generators because an earlier, smaller study used topographic covariance model did not show localized predict risk for schizophrenia.P300 66 patients, 115 healthy 89...
Background Patients with peripheral arterial disease often experience treatment failure from restenosis at the site of a prior endovascular intervention ( PVI ) or lower extremity bypass LEB ). The impact these failures on utilization and outcomes secondary interventions is poorly understood. Methods Results In our regional vascular quality improvement collaborative, we compared 2350 patients undergoing primary infrainguinal 1154 performed after previous revascularization in index limb)...