Deep brain stimulation (DBS) has provided new treatment options for refractory epilepsy; however, outcomes of DBS in epilepsy patients previously treated with vagus nerve (VNS) have not been clarified. Herein, the anterior nucleus thalamus (ANT-DBS) who had experienced VNS failure are reported. Seven underwent ANT-DBS device implantation. was turned off before Monthly seizure counts starting from baseline to 12–18 months after were analyzed. Five (71.3%) 7 a >50% reduction DBS; 1...

Abstract Study Objectives Previous functional MRI studies have reported altered brain networks in patients with obstructive sleep apnea (OSA). However, the extent and pattern of abnormal connectivity were inconsistent across studies, cerebrocerebellar connections been rarely assessed. We investigated network changes cerebral cerebellar cortices OSA patients. Methods Resting-state MRI, polysomnography, neuropsychological (NP) test data acquired from 74 (age: 45.8 ± 10.7 years) 33 healthy...

Circadian medicine aims to leverage the body’s internal clock develop safer and more effective therapeutics. Traditionally, biological time has been estimated using dim light melatonin onset (DLMO), a method that requires collecting saliva samples over long period under controlled conditions, ensure observation of DLMO, making it time-consuming labor-intensive. While some studies have mitigated this by reducing length sampling window, they significantly failed identify DLMO for shift...

Altered cerebral perfusion has been reported in obstructive sleep apnea (OSA). Using dynamic susceptibility contrast MRI, we compared between male OSA patients and healthy reference subjects assessed correlations of abnormalities with parameters neuropsychological deficits at 3 T polysomnography tests 68 21 subjects. We found lower global regional blood flow volume, localized mainly bilateral parietal prefrontal cortices, as well multiple focal cortical deep structures related to the default...

Currently, information on sleep and circadian patterns in relation to COVID-19 or vaccination remains limited. We aimed investigate according history of side effects. used data from the National Sleep Survey South Korea 2022, a nationwide cross-sectional population-based survey regarding sleep-wake behaviors problems among Korean adults. Analysis covariance (ANCOVA) logistic regression analyses were performed explore different self-reported effects vaccination. The ANCOVA showed that...

Background and Purpose Sleep disturbance is common in patients with primary headache disorders.We were interest whether poor sleep quality affects directly or via increases the frequency severity of headaches.To that end, we investigated direct indirect effects on headache-related impact among disorders.Methods We analyzed migraine tension-type (TTH) included registry our clinic from October 2015 to May 2018.We collected information frequency, severity, psychological status.Sleep measured...

Abstract Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations specific WM tracts clarify pathophysiological mechanisms of RLS. We enrolled 30 RLS and 31 age- sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, polysomnography. Fractional...

Melatonin and cortisol are clinically important for diagnosing sleep mood disorders.We developed validated a liquid chromatography-tandem mass spectrometry (LC-MS/ MS) assay simultaneous measurement of salivary melatonin concentrations according to the Clinical Laboratory Standards Institute guidelines.Additionally, we compared LC-MS/MS with immunoassays, ELISA (Direct Salivary Elisa EK-DSM, Bühlmann Laboratories AG, Schönenbuch, Switzerland) electrochemiluminescence immunoassay (Cortisol...

Epidemiological data on narcolepsy are rare in South Korea. We aimed to provide an overview of the burden and its temporal trend Korea.Patients with were identified by their registration Rare Intractable Disease (RID) register Health Insurance Review Assessment database. Individuals registered RID program code V234 considered as having 'definite narcolepsy', while those who claimed health insurance G47.4 primary diagnostic 'probable narcolepsy'. estimated annual prevalence, incidence,...

Unlike young-onset Parkinson disease (YOPD), characteristics of late-onset PD (LOPD) have not yet been clearly elucidated. We investigated characteristic features and symptoms related to quality life (QoL) in LOPD patients.We recruited drug-naïve, early patients. The patient cohort was divided into 3 subgroups based on age at onset (AAO): the YOPD group (AAO <50 years), middle-onset (MOPD) group, ≥70 years). Using various scales for motor (MS) non-MS (NMS) QoL, we compared clinical impact...

Organic light-emitting diodes (OLEDs) emit less blue light than traditional (LEDs), but the effects of OLED exposure (LE) on melatonin and sleep have not been evaluated.Twenty-four healthy subjects (age 26.9±5.7 years; including 18 females) with intermediate chronotype were exposed to three different conditions [4,000 K 150 lux LE, 4,000 LED dim (DL) at <10 lux] for 6.5 h from 17:30 24:00, in a random order 1-week interval. Participants entered unit experiment 16:00, their daylight was...

Abstract Objective This longitudinal study investigated potential positive impact of CPAP treatment on brain health in individuals with obstructive sleep Apnea (OSA). To allow this, we aimed to employ electroencephalogram (EEG)‐derived age index (BAI) quantify CPAP's and identify individually varying effects aging using machine learning approaches. Methods We retrospectively analyzed CPAP‐treated ( n = 98) untreated OSA patients 88) a minimum 12‐month follow‐up polysomnography. BAI was...

Objective/background To assess whether cerebral structural alterations in isolated rapid eye movement sleep behavior disorder (iRBD) are progressive and differ from those of normal aging they related to clinical symptoms. Patients/methods In a longitudinal study 18 patients with iRBD (age, 66.1 ± 5.7 years; 13 males; follow-up, 1.6 0.6 years) 24 age-matched healthy controls 67.0 4.9 12 2.0 0.9 years), all participants underwent multiple extensive examinations, neuropsychological tests,...

Neurofibromatosis type 1 (NF1) is the most common neurocutaneous disease. Main neurologic manifestations are represented by neoplasms such as optic gliomas, but epilepsy can occur CNS lesions in less than 10%. Our patient was diagnosed, based on café-au-lait spots and axillary freckles. Her brain MRI did not show only multiple lesions, like hamartomas, also mesial temporal lesions. On brain-MRI had increased high signal intensities suspiciously volume. Moreover scalp could be confirmed...

Intracranial infection caused by anaerobic bacteria is rare, and it difficult to identify absolute anaerobes in the clinical laboratory, especially when bacterial load low. Here, we report first case of intracranial mycotic aneurysm &lt;i&gt;Prevotella intermedia&lt;/i&gt; associated with chronic sinusitis successful identification 16S rRNA sequencing from growth broth only.

Objective Organic light-emitting diodes (OLEDs) emit less blue light than traditional (LEDs), and we previously found that early-night OLED exposure (LE) delays the melatonin phase by LED at a color temperature of 4,000 K. As follow-up study, investigated effects different (3,000 K) on profile, sleep, vigilance.Methods 24 healthy subjects (27.5±5.1 years) were exposed to three conditions [OLED, LED, dim (DL)] from 17:30 24:00, in random order with 1-week interval. Saliva samples for taken...

Objective To determine the natural course of cluster headache. Methods We screened patients with headache who were diagnosed at Samsung Medical Center and lost to follow-up for ≥5 years. Eligible interviewed by phone about longitudinal changes in characteristics disease course. Remission was defined as symptom-free 1) longer than twice longest between-bout period 2) Results Forty-two mean 7.5 (range, 5.0–15.7) years included. The length last bout did not differ from first one, while one ( p...

Objectives: In South Korea, a significant number of patients with obstructive sleep apnea have benefited from the insured continuous positive pressure for as 2018. However, there is limited information on public awareness syndrome in country. A nationwide survey was conducted to evaluate current status diagnosis and treatment apnea. Methods: We an online using structured questionnaires symptoms knowledge modalities total 4,000 participants aged 21 69 were proportionally allocated according...

Study objectives Obstructive sleep apnea (OSA) is a prevalent clinical problem significantly affecting cognitive functions. Surgical treatment recommended for those unable to use continuous positive airway pressure. We aimed investigate the therapeutic effect of upper surgery on white matter (WM) microstructure and brain connectivity in patients with OSA. Methods Twenty-one male moderate-to-severe OSA were recruited multi-level surgery. Overnight polysomnography (PSG), neuropsychiatric...