A5043140366- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Advancements in Semiconductor Devices and Circuit Design
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- Yersinia bacterium, plague, ectoparasites research
- T-cell and B-cell Immunology
- Silicon Carbide Semiconductor Technologies
- COVID-19 epidemiological studies
- Nanowire Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- COVID-19 Clinical Research Studies
- Vector-borne infectious diseases
Children's Hospital of Philadelphia
2024
University of Pennsylvania
2023-2024
University of Nevada, Reno
2021-2023
University of Minnesota
2022
University of Minnesota Medical Center
2022
University of Washington
2022
A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence these cells in vivo
The incidence of fatal drug overdoses in the United States is an alarming public health threat that has been exacerbated by COVID-19 pandemic, resulting over 100,000 deaths between April 2020 and 2021. A significant portion this attributable to widespread access fentanyl other synthetic opioids, alone or combination with heroin psychostimulants, such as cocaine methamphetamine. Monoclonal antibodies (mAb) offer prophylactic therapeutic interventions against opioid overdose binding opioids...
Poor CAR T persistence limits cell therapies for B malignancies and solid tumors
Background Yersinia pestis is the causative agent of plague, a zoonosis associated with small mammals. Plague severe disease, especially in pneumonic and septicemic forms, where fatality rates approach 100% if left untreated. The bacterium primarily transmitted via flea bite or through direct contact an infected host. 2017 plague outbreak Madagascar resulted more than 2,400 cases was highlighted by increased number infections. Standard diagnostics for include laboratory-based assays such as...
Francisella tularensis is the causative agent of tularemia, a zoonotic bacterial infection that often fatal if not diagnosed and treated promptly. Natural in humans relatively rare, yet persistence animal reservoirs, arthropod vectors, water sources combined with low level clinical recognition make tularemia serious potential threat to public health endemic areas. F. has also garnered attention as bioterror threat, widespread dissemination could have devastating consequences on population. A...
<h3>Background</h3> CAR T cell therapy is a promising therapeutic modality for cancer treatment, but poor persistence limits efficacy in patients.<sup>1</sup> cells with memory-like phenotype are associated durable patients and response to therapy,<sup>2</sup> thereby implicating memory as an important axis. Thus, strategies stably promote differentiation urgently needed. Here, we demonstrate that FOXO1 required the development of overexpression maintains gene expression programs enhances...
<h3>Background</h3> Poor CAR T cell persistence is a major factor limiting durable responses to therapy. TCF1 transcription that regulates the expression of memory-related genes and its correlates with clinical persistence, making it promising target for enhancing efficacy. Despite TCF1's established role in memory stemness, overexpression alone does not enforce memory-like phenotype or improve potency,<sup>1</sup> indicating function relevance human cells unclear. These results highlight...
Antibodies reactive with the SARS-CoV-2 receptor-binding domain (RBD) of spike protein are associated viral neutralization, however low antibody titers, specifically against variants, may result in reduced immunity post naturally acquired infection. A cohort study comprised 121 convalescent individuals from northern Nevada was conducted looking at anti-RBD levels by enzyme-linked immunosorbent assay. Serum collected volunteers staff University Nevada, Reno School Medicine Clinical Research...
Summary Background Robust diagnostics, capable of detecting multiple variant SARS-CoV-2 are necessary to mitigate the COVID-19 pandemic. In this study we directly compare diagnostic capabilities an LFI engineered with monoclonal antibodies (mAbs) originating from NP immunizations Abbott BinaxNOW™ Antigen CARD. Methods Here established a library 18 mAbs specific and used two these (1CV7 1CV14) generate prototype antigen-detection lateral flow immunoassay (LFI). Samples consisting remnant...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for COVID-19 pandemic. From onset of pandemic, rapid antigen tests have quickly proved themselves to be an accurate and accessible diagnostic platform. The initial (and still most commonly used tests) diagnosis were constructed using monoclonal antibodies (mAbs) specific severe (SARS-CoV) nucleocapsid protein (NP). These mAbs are able bind SARS-CoV-2 NP due high homology between two viruses. However, since...
Abstract Ebola Virus Disease (EVD) is a deadly infectious disease that caused by an infection with virus (EBOV). EVD one of the deadliest viral diseases human case fatality rate up to 90%. The largest outbreak date was 2013–2016 West African in which Zaire ebolavirus (ZEBOV) responsible for over 11,000 deaths. Transmission can occur through contact infected animal or human. Early detection imperative prevent spread and reduce risk potential epidemic isolating known patients. current gold...