A5009842149- Nanoplatforms for cancer theranostics
- Adaptive Control of Nonlinear Systems
- Control and Dynamics of Mobile Robots
- Aerospace Engineering and Control Systems
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Cancer Research and Treatments
- Chemical Synthesis and Analysis
- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- CAR-T cell therapy research
- Graphene and Nanomaterials Applications
- Tryptophan and brain disorders
- Advanced Drug Delivery Systems
- Stability and Control of Uncertain Systems
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Lipid Membrane Structure and Behavior
- Protein Degradation and Inhibitors
South China University of Technology
2018-2025
Ministry of Education of the People's Republic of China
2018-2020
Abstract Novel strategies to facilitate tumor‐specific drug delivery and restore immune attacks remain challenging in overcoming the current limitations of chemoimmunotherapy. An antitumor chemoimmunotherapy system comprising bioorthogonal reaction‐ready group tetrazine (TZ) modified with an anti‐PD‐L1 antibody (αPD‐L1 TZ ) TZ‐activatable prodrug vinyl ether‐doxorubicin (DOX‐VE) for self‐reinforced anti‐tumor is proposed. The αPD‐L1 effectively disrupts PD‐L1/PD‐1 interaction activates DOX...
The degradation of oncoproteins mediated by proteolysis-targeting chimera (PROTAC) has emerged as a potent strategy in cancer therapy. However, the clinical application PROTACs is hampered challenges such poor water solubility and off-target adverse effects. Herein, we present an ultrasound (US)-activatable PROTAC prodrug termed NP
Abstract Precise control over drug release rates is critical for enhancing therapeutic efficacy, reducing side effects, and maintaining stable levels. While microneedles (MNs) offer a promising approach transdermal delivery, conventional passive‐response systems often lack adaptability across diverse drugs disease models, limiting their versatility. Here, this work presents flexible bioelectronic microneedle patch (FBMP) that integrates electronics actively controlled delivery. The FBMP...
This paper presents a novel fixed time sliding mode disturbance observer (FTSMDO) based second-order control (FTSMC) for small scale unmanned helicopter to do hover operations in the presence of external disturbances. Sliding is insensitive matched uncertainties but sensitive mismatched uncertainties. The FTSMDO exactly estimates total effecting performance. To counter new surface augmented by approximated defined. FTSMC forces system states reach and then on exponentially converge desired...
This paper presents a robust control technique for small-scale unmanned helicopters to track predefined trajectories (velocities and heading) in the presence of bounded external disturbances.The controller design is based on linearized state-space model helicopter.The multivariable dynamics helicopter divided into two subsystems, longitudinallateral heading-heave respectively.There no strong coupling between these subsystems independent controllers are designed each subsystem.The...
Despite cisplatin's pivotal role in clinically proven anticancer drugs, its application has been hampered by severe side effects and a grim prognosis.
Numerous control techniques are developed for miniature unmanned helicopters to do hover operation with each method having its own advantages and limitations.During the suffer from unknown external disturbances such as wind ground effect.For a stable operation, these must be compensated accurately.This paper presents disturbance observer based sliding mode technique small-scale in presence of disturbances.To counteract both matched mismatched uncertainties new surface is designed on...
Chemotherapy is the primary treatment option for pancreatic cancer, although nanocarrier-based drug delivery systems often struggle with multiple physiological barriers, limiting their therapeutic efficacy. Here, we developed a pH/reactive oxygen species (ROS) dual-sensitive self-adaptive nanocarrier (DATCPT) encapsulating camptothecin (CPT), an analog of chemotherapeutic irinotecan (CPT-11), to enhance chemotherapy outcomes in orthotopic cancer by addressing barriers. The features...