A5050044548- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thermoregulation and physiological responses
- Infrared Thermography in Medicine
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Male Breast Health Studies
- Cardiac Arrest and Resuscitation
- Adipose Tissue and Metabolism
- Spine and Intervertebral Disc Pathology
- Opioid Use Disorder Treatment
- Cardiovascular Disease and Adiposity
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Birth, Development, and Health
- Medication Adherence and Compliance
- Evolutionary Psychology and Human Behavior
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Retinal and Optic Conditions
- Cervical and Thoracic Myelopathy
- Retinal Diseases and Treatments
- Thyroid Disorders and Treatments
- Physiological and biochemical adaptations
Mayo Clinic in Arizona
2020-2022
Mayo Clinic
2020-2021
Mayo Clinic in Florida
2021
WinnMed
2021
University of Cambridge
2018
NHS Lothian
2015
Background: Considerable uncertainty remains about the pattern of use treatment options for Graves' disease (GD) and their comparative effectiveness safety. Methods: Between 2005 2013, we identified patients with GD who received antithyroid drugs (ATDs), radioactive iodine (RAI) or surgery, were represented in a large administrative data set United States (OptumLabs® Data Warehouse). Results: We 4661 GD: mean age 48 (SD ±14) years, white (63%), female (80%). Patients ATD, n = 2817 (60%),...
Rationale: In October 2014, the antifibrotic medications pirfenidone and nintedanib became first approved by U.S. Food Drug Administration for use in patients with idiopathic pulmonary fibrosis (IPF). Since approval, there has been no nonregistry analysis of real-world adoption these everyday clinical practice. Objectives: To evaluate adoption, persistence, out-of-pocket (OOP) costs since their approval United States 2014. Methods: A retrospective cohort was performed identifying privately...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high morbidity and limited treatment options. Type 2 diabetes mellitus (T2DM) common comorbid illness among patients IPF often treated metformin, the first-line agent in management of T2DM. There growing evidence demonstrating metformin’s anti-fibrotic properties; however, there little real-world clinical data regarding its potential effectiveness IPF. This study aims to evaluate benefit...
Abstract Objectives This study investigated the influence of body size and composition on maintaining hand temperature during severe cold exposure. The hand's high surface area‐to‐volume ratio predisposes to heat loss, increasing risk injury even hypothermia, which are major selective pressures in environments. While vasoregulation may reduce loss from hand, effect form, tissue thermogenesis, insulation is unknown. Materials Methods Thermal imaging was used determine a 3‐min ice‐water...
Sustained postoperative opioid use after elective surgery is a matter of growing concern. Herein, the authors investigated incidence and predictors long-term among patients undergoing lumbar spine surgery, especially as function prescribing practices at discharge (dose in morphine milligram equivalents [MMEs] type opioid).
To evaluate post-acute care utilization and readmissions after cardiac arrest (CA) cardiogenic shock (CS) complicating acute myocardial infarction (AMI).With use of an administrative claims database, AMI patients from January 1, 2010, to May 31, 2018, were stratified into CA+CS, CA only, CS alone. Outcomes included 90-day (inpatient rehabilitation or skilled nursing facility) 1-year emergency department visits readmissions.Of 163,071 patients, only noted in 3965 (2.4%), 8221 (5.0%), 6559...
The multi-stress environment of high altitude has been associated with growth deficits in humans, particularly zeugopod elements (forearm and lower leg). This is consistent the thrifty phenotype hypothesis, which observed Andeans, but yet to be tested other high-altitude populations. In Himalayan populations, factors, such as cold stress, may shape limb proportions. current study investigated whether relative upper proportions adults (n = 254) differ between highland lowland adaptation or a...
Abstract Objectives The current study investigated whether size and proportions of the hands digits affect dexterity during severe cold exposure. As wide are known to lose less heat than narrow hands, associated with greater dexterity, this aimed test there was a direct trade‐off between thermoregulation that shapes hand morphology. Methods Participants (25 women, 15 men) carried out Purdue Pegboard before after 3‐min ice‐water immersion hand. Their length, width, digit lengths, widths were...
Abstract Objectives The current study assessed whether ecogeographical patterns seen in hand proportions correlate with heat loss directly. Using a brief severe cold immersion experiment on the hand, influence of and digit dimensions was evaluated. Materials methods A sample 113 living individuals were tested. Two‐dimensional three‐dimensional scanning techniques used to assess dimensions. Thermal imaging analysis quantify during 3‐min ice‐water hands. Results When body size accounted for,...
Abstract Background Idiopathic Pulmonary Fibrosis is a chronic, progressive interstitial lung disease for which there no cure. However, function decline, hospitalizations, and mortality may be reduced with the use of antifibrotic medications, nintedanib pirfenidone. Historical outcomes hospitalized patients are grim; however paucity data since approval pirfenidone treatment. In this study, we aimed to determine effect on following respiratory-related intensive care unit (ICU) admission,...
Objective Increasing uptake of cancer screening is a priority for health systems internationally, however, some patients may not attend because they are undergoing active treatment the interest or have other medical reasons that mean participation would be inappropriate. This study aims to quantify proportion non-participants who reason attending screening. Methods Medical participating in breast and bowel were defined priori on basis literature review expert opinion. The notes 700 at two GP...
INTRODUCTION: Lumbar spine surgery has been reported to be associated with extremely high direct and costs thus prioritized as a target for several quality improvement interventions. We aimed identify factors higher 90-d following elective posterior lumbar fusion (PLF) degenerative disease among patients commercial insurance those on Medicare Advantage, using an administrative database. METHODS: Optum Labs Data Warehouse was queried undergoing PLF between 2012 2015. Patients were stratified...
INTRODUCTION: Anterior Cervical Discectomy and Fusion (ACDF) has been shown to be associated with high direct costs. We aimed identify factors higher 90-day costs following elective ACDF for degenerative cervical spine disease among patients commercial insurance those on Medicare Advantage, using an administrative database. METHODS: Optum Labs Data Warehouse (OLDH) was queried undergoing anterior decompression fusion disease. between 2012 2015. Geographic variations were evaluated as per...
Abstract Background: The clinical utility of routine annual mammogram after curative-intent treatment for male breast cancer is uncertain. There potentially greater value lumpectomy (as surveillance ipsilateral recurrence) than mastectomy screening a new contralateral cancer). goal this study was to assess real world use mammography in men during the first year or treat cancer. Methods: Administrative claims data from OptumLabs Data Warehouse (a large US database that includes privately...