A5101841936- Adenosine and Purinergic Signaling
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
- Oral and Maxillofacial Pathology
- Peptidase Inhibition and Analysis
- Advanced Breast Cancer Therapies
- Chromatin Remodeling and Cancer
- Bone Tumor Diagnosis and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Oral and gingival health research
- Cancer Mechanisms and Therapy
- Schizophrenia research and treatment
- Psidium guajava Extracts and Applications
- Forensic and Genetic Research
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Garlic and Onion Studies
- Genomic variations and chromosomal abnormalities
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Genomics and Rare Diseases
- Microtubule and mitosis dynamics
- Congenital limb and hand anomalies
- COVID-19 epidemiological studies
- Gastric Cancer Management and Outcomes
Aurigene Discovery Technologies (India)
2019-2023
Maharana Pratap University of Agriculture and Technology
2015-2022
Datta Meghe Institute of Medical Sciences
2021
Government Medical College and Hospital
2021
Jawaharlal Nehru Medical College
2021
St. George's University
2020
Teerthanker Mahaveer Medical College & Research Centre
2020
San Joaquin General Hospital
2020
California Northstate University
2020
Government Medical College and Hospital
2018
18p deletion syndrome is characterized by the of short arm chromosome 18. Presentation this quite variable with dysmorphic features, growth deficiencies, and mental retardation poor verbal performance. Few patients even fail to thrive when malformations involving heart brain are severe. In present article, we report an isolated case in a 23-year-old female who for first time reported hospital dental problems. The patient was statured craniofacial, skeletal, dental, endocrinal abnormalities....
Immunoglobulin G4-related disease (IgG4-RD) is a chronic multisystem immune-mediated disease. Histologically, it presents as infiltration with IgG4-secreting plasma cells affecting many organs such the pancreas, lacrimal glands, salivary kidneys, and arteries, resulting in fibrosis scarring within tissue which over time forms into mass. It slow-growing process that usually remains indolent until causes mass effect or infiltration. Our patient was found to have pancreatic on imaging...
Osteochondroma is the most common benign neoplasm of skeleton commonly affecting long bones due to endochondral growth. In craniofacial region this tumour very rare. The sites predilection are coronoid process and mandibular condyle. Here, we report an exceptional case osteochondroma originating from maxillary posterior in a 26-year-old male patient, mimicking odontome, not reported earlier literature. We also discuss importance various imaging modalities, importantly, computed tomography...
Fungal infections caused by Candida albicans present significant challenges in clinical settings owing to rising resistance conventional antifungal treatments. Natural products derived from medicinal plants, including tulsi (Ocimum sanctum), garlic (Allium sativum), cinnamon (Cinnamomum verum) and lemongrass (Cymbopogon citratus) are increasingly recognized for their potential antimicrobial properties as alternative sources of therapies. This study evaluated the efficacy Tulsi, Garlic,...
Cyclin-dependent kinase 2 (CDK2) is an established target protein for therapeutic intervention in various diseases, including cancer. Reported inhibitors of CDK2 the ATP-binding pocket to inhibit activity. Many small molecule have been discovered, and their crystal structure with or CDK2-cyclin A complex has published. NU6140 a inhibitor moderate potency selectivity. Herein, we report cocrystal determination confirmation binding using biophysical methods. Our data show that binds Kd 800 nM...
Abstract Background Colonoscopy screenings are the most valuable tool in preventing colorectal mortalities. The traditional technique uses air-insufflation, but water-infusion is a newer colonoscopy which rapidly becoming standard of care, as it may decrease patient discomfort and need for analgesics anesthetics. Research still ongoing to comparability detection rates between two techniques. purpose this study was determine if training residents underwater colonoscopies more effective than...
As a potent immunosuppressor adenosine is essential for maintaining tissue homeostasis and preventing an overzealous immune response during inflammation infection. However, generated within the tumor microenvironment by action of ecto-nucleotidases including CD73 hinders reaction towards cancer cells signaling through receptors such as high affinity A2AR expressed on cells. Inhibitions either generation or inhibiting have been shown to be effective therapeutic approaches. Interestingly,...
Abstract Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing nucleosomes to regulate transcription, DNA replication/repair chromosome dynamics. is known be mutated number cancers lacking targetable oncogenes, with SMARCA4-mutant patient population representing 10%-20% NSCLC, 100% small cell ovarian cancer (hypercalcemic type), 28% skin cancer, 16% glioma 14% colon cancer. Genetic studies have...
Abstract As a potent immunosuppressor adenosine is essential for maintaining tissue homeostasis and preventing an overzealous immune response during inflammation infection. However, generated within the tumor microenvironment by action of ectonucleotides hinders reaction towards cancer cells signaling through receptors such as high affinity A2AR expressed on cells. Tumors evade usurping pathways that negatively regulate normal responses. Resistance to inhibition checkpoint targets arises...
Abstract Background: The BAF (SWI/SNF) chromatin remodeling complex comprises of two mutually exclusive ATPases, SMARCA2 (BRM) and SMARCA4 (BRG1), that affect the mobilization positioning nucleosomes on DNA thereby regulate important cellular functions including transcription, recombination, repair chromosome decatenation during mitosis. is frequently overexpressed in several types cancers. Overexpression has been linked to increased proliferation survival, as well aggressive tumors poor...
Abstract KAT6 paralogs KAT6A (MOZ; MYST3) and KAT6B (MORF; MOZ2; MYST4) are histone acetyltransferase (HAT) enzymes that acetylate H3 thereby epigenetically regulate gene transcription by altering chromatin structure. Dysregulation of activity (gene amplification, overexpression, fusion, mutation, etc.) is observed in breast other cancers. In several subtypes cancer, amplified as part the 8p11-p12 amplicon and/or overexpressed 11 to 15% overall cancer population. Overexpression correlates...
Zimmermann-Laband Syndrome: Report of a Case with Early Cardiac Complications 1Atul P Sattur, 1Krishna N Burde, 2Venkatesh G Naikmasur, 3Megha Goyal 1Professor, Department Oral Medicine and Radiology, SDM College Dental Sciences Hospital, Dharwar Karnataka, India 2Professor Head, 3Postgraduate Student,
Abstract As a potent immunosuppressor adenosine is essential for maintaining tissue homeostasis and preventing an overzealous immune response during inflammation infection. However, generated within the tumor microenvironment by action of ecto-nucleotidases including CD73 hinders reaction towards cancer cells signaling through receptors such as high affinity A2AR expressed on cells. Inhibitions either generation or inhibiting have been shown to be effective therapeutic approaches....
Background: Hyperbilirubinemia in neonates is considered to be one of the common phenomena which generally occurs during first week life and usually leads NICU admission both term preterm new-born babies. It also regarded as most causes neonatal morbidity mortality.Methods: A total 100 along with their mothers were enrolled study from time period between 2018 March 2019. Newborns assessed daily for jaundice serum bilirubin levels done. Various fetal-maternal factors included proforma were....
Background: Most studies of COVID vaccination focused on cell-mediated immunity and serum IgG antibodies, overlooking the role anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) neutralizing IgA antibodies in preventing viral infection. SARS-CoV-2 vaccine generates variable Anti-Spike responses following one or two doses almost all individuals for protection. Aim: The study aimed to quantify estimate antibody response after second dose Covishield healthcare workers (HCWs) over...
Abstract CD73 is a cell surface ectoenzyme, which overexpressed in many types of human and mouse cancers. the primary enzymatic producer immunosuppressive adenosine tumor microenvironment, high expression associated with significantly poorer prognosis several types. Inhibition either generation or signaling by inhibiting have been shown to be effective therapeutic approaches. Here we sought discover develop novel orally bioavailable small molecule inhibitors that target CD73. Aurigene's...