A5015797215- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Asphalt Pavement Performance Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organophosphorus compounds synthesis
- Vehicle emissions and performance
- Asymmetric Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Fluorine in Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Air Quality and Health Impacts
- Mine drainage and remediation techniques
- Inorganic Fluorides and Related Compounds
- Radioactive element chemistry and processing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Petroleum Processing and Analysis
- History and advancements in chemistry
- Job Satisfaction and Organizational Behavior
- scientometrics and bibliometrics research
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
Emory University
2023-2025
Arizona State University
2021-2023
University of Rochester
2014-2019
Princeton University
2018
University of Hawaii System
2010-2011
Scripps College
2010
Scripps Health
2010
University of South Florida
1992
A new method for the decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with aryl iodides is presented. In contrast to previous studies that form radicals from carboxylic acid derivatives, no photocatalyst, light, or arylmetal reagent needed, only nickel and a reducing agent (Zn). Methyl, primary, secondary groups can all be coupled in good yield (77% ave yield). One an chloride also Stoichiometric reactions (dtbbpy)Ni(2-tolyl)I NHP ester show first time...
A method for direct cross coupling between unactivated C(sp3)-H bonds and chloroformates has been accomplished via nickel photoredox catalysis. diverse range of feedstock chemicals, such as (a)cyclic alkanes toluenes, along with late-stage intermediates, undergo intermolecular C-C bond formation to afford esters under mild conditions using only 3 equiv the C-H partner. Site selectivity is predictable according strength polarity trends that are consistent intermediacy a chlorine radical...
Cobalt phthalocyanine mediated generation of benzylic radicals from sulfonate esters enables the selective nickel-catalyzed synthesis diarylmethanes.
While the synthesis of biaryls has advanced rapidly in past decades, cross-Ullman couplings aryl chlorides, most abundant electrophiles, have remained elusive. Reported here is first general coupling chlorides with triflates. The selectivity challenge associated an inert electrophile a reactive one overcome using multimetallic strategy appropriate choice additive. Studies demonstrate that LiCl essential for effective cross-coupling by accelerating reduction Ni(II) to Ni(0) and counteracting...
Cross-electrophile coupling of aryl halides with alkyl has thus far been primarily conducted stoichiometric metallic reductants in amide solvents. This report demonstrates that the use tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables non-amide solvents, such acetonitrile or propylene oxide, for benzyl chlorides and iodides halides. Furthermore, these conditions work several electron-poor heterocycles are easily reduced by manganese. Finally, we demonstrate TDAE addition...
This study introduces iron-rich biochar to selectively adsorb some volatile organic compounds (VOCs) emitted from asphalt-surfaced areas. Adsorption and retention of VOCs can improve the air quality while reducing asphalt's mass loss which compromises durability. The was made a hybrid feedstock Cyanidioschyzon merolae (CM) algae swine manure (SM) with blend 20:80 CM/SM, showing highest yield 27 wt % metal content Fe (21.8 g kg–1). Comparison VOC adsorption low-iron shows significant role in...
High-throughput experimentation (HTE), the miniaturization and parallelization of reactions, is a valuable tool for accelerating diverse compound library generation, optimizing reaction conditions, enabling data collection machine learning (ML) applications. When applied to organic synthesis methodology, HTE still poses various challenges due workflows reagents utilized, requiring advancements in design, execution, analysis, management. To address these limitations, cutting-edge...
This paper investigates the role of phenolic compounds in biochar's adsorption capacity toward volatile organic (VOCs) emitted from asphalt. Considering impact preparation technique on composition, our findings show that biochar produced through fixed-bed contained more functional groups than fluidized-bed technique. Specifically, Fourier transform infrared analysis showed a higher concentration OH biochar, consistent with its nearly 3-fold oxygen content (6.37 ± 0.52 wt %) compared to (2.36...
Decarboxylative cross-coupling of carboxylic acids and aryl halides has become a key transformation in organic synthesis to form C(sp
Most research on job analysis treats within‐job interrater disagreement structured surveys as measurement error. The present conceptualized time‐spent responses expressions of time allocation strategies for the relatively autonomous stockbroker job, and differences between reflecting different strategies. Stockbrokers ( n = 580) in a large financial services firm provided data survey, results showed that inexperienced stockbrokers (with 1‐4 years’job experience), more experienced with than 4...
Abstract Facile synthetic routes to a chiral chloro‐substituted biphenyl‐2,2′‐diyl hydrogen phosphate and O , ‐biphenyl‐2,2′‐diyl phosphoramidothioate are described. The performance of these compounds as catalysts for the hydrophosphonylation imines Friedel–Crafts alkylation indole was investigated. In latter reaction, phosphoric acid derivative found rival best Brønsted reported date.
Asphalt is used globally in construction for roads, pavements, and buildings; however, as a fossil-derived material, it known to generate volatile organic compounds (VOCs) upon exposure heat light that can be harmful human health. Several heterogeneous strategies have been reported the inhibition of these VOCs; direct use inexpensive, accessible Earth-Abundant metals has not extensively explored. In this study, simple metal salts are examined their coordination capability toward...
Decarboxylative cross-coupling of carboxylic acids and aryl halides has become a key transformation in organic synthe- sis to form C(sp2)–C(sp3) bonds. In this report, base metal pairing between Fe Ni been developed with complementary reactivity the well-established Ir metallaphotoredox reactions. Utilizing an inexpensive FeCl3 co-catalyst along pyr- idine carboxamidine catalyst, range iodides can be preferentially coupled over boronic acid esters, triflates, chlorides, even bromides high...
A general Fe photocatalyzed Giese reaction was developed using a unique analytical technique for synthetic organic chemistry: Thermal Gravimetric Analysis-Fourier Transform Infrared Spectroscopy (TGA-FTIR). The optimized conditions proceed with low loadings of simple salt commercial amine ligand and obviates the need traditional large excess one coupling partner to facilitate radical capture. This protocol enables successful primary, secondary, tertiary carboxylic acids sterically hindered,...