A5073772102- T-cell and B-cell Immunology
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- NF-κB Signaling Pathways
University of California, San Diego
2019-2023
Scripps Research Institute
2018-2019
CTCF is largely responsible for the 3D architecture of genome through creation long-range chromatin loops. Cohesin hypothesized to be main driver these interactions by process loop extrusion. Here we performed ChIP-seq and cohesin in 2 stages each T B cell differentiation examined binding pattern all 6 antigen receptor (AgR) loci lymphocyte progenitors mature cells, ES cells fibroblasts. The 4 large AgR have many bound sites, most which are only occupied lymphocytes, while sites at end locus...
Abstract Effective Ab-mediated responses depend on a highly diverse Ab repertoire with the ability to bind wide range of epitopes in disease-causing agents. The generation this depends somatic recombination variable (V), diversity (D), and joining (J) genes Ig loci developing B cells. It has been known for some time that individual V, D, J gene segments rearrange at different frequencies, but mechanisms behind unequal V usage have not well understood. However, recent work revealed newly...