Summary Although chronic infection with cytomegalovirus ( CMV ) is known to drive T lymphocytes toward a senescent phenotype, it remains controversial whether and how can cause coronary heart disease CHD ). To explore seropositivity or T‐cell populations associated immunosenescence were informative for adverse cardiovascular outcome in the very old, we prospectively analyzed peripheral blood samples from 751 octogenarians (38% males) Newcastle 85+ study their power predict survival during...

Perturbations in thyroid function are common older individuals but their significance the very old is not fully understood. This study sought to determine whether hormone status and variation of hormones within reference range correlated with mortality disability a cohort 85-year-olds. A 85-year-old were assessed own homes (community or institutional care) for health function, followed up 9 years. Six hundred forty-three 85-year-olds registered participating general practices Newcastle North...

Objectives . To examine the extent and complexity of morbidity burden in 85-year-olds; identify patterns within multimorbidity; explore associations with medication healthcare use. Participants 710 men women; mean (SD) age 85.5 (0.4) years. Methods Data on 20 chronic conditions (diseases geriatric conditions) ascertained from general practice records participant assessment. Cluster analysis multimorbid sample identified subgroups sharing profiles. Clusters were compared Results 92.7%...

Abstract Background Atrial fibrillation (AF) is common in older people and associated with increased stroke risk that may be reduced by oral anticoagulation (OAC). Frailty also increases increasing age, yet the extent of OAC prescription according to frailty AF insufficiently described. Methods An electronic health records study 536,955 patients aged ≥65 years from ResearchOne England (384 General Practices), over 15.4 months, last follow-up 11th April 2017. for CHA2DS2-Vasc ≥2, adjusted...

The aim of the current study was to identify specific patterns physical multimorbidity and examine how these associated with changes in social participation over time.We used latent class analysis clusters 11,391 older adults. Mixed effects regression models were assess associations between 15 years.Four identified. All a reduction cultural engagement (e.g. visits theatre, cinema, museums) time, strongest association seen complex/multisystem cluster (β = -0.26, 95% CI -0.38 -0.15). Similar...

Using Newcastle 85+ Study data, we investigated transitions between frailty states from age 85 to 90 years and whether multi-morbidities socioeconomic status (SES) modify transitions.The is a prospective, longitudinal cohort study of all people born in 1921 North Tyneside. Data included: multidimensional health assessment; general practice record review (GPRR) date death. the Fried phenotype (participants defined as robust, pre-frail or frail), was measured at baseline, 18, 36 60...

Purpose: Keratoconus progression should be treated with corneal cross-linking (CXL) in a timely manner. This study aimed to investigate patient factors associated keratoconus between time of listing and at CXL. Methods: Prospective observational tertiary center. Ninety-six eyes 96 patients keratoconus. Demographic, clinical, tomographic parameters were analyzed determine the risk for progression. Analyzed indices included steepest keratometry, average cornea thinnest point, index surface...

Abstract Background Comorbidity is common and has a substantial negative impact on the prognosis of patients with acute myocardial infarction (AMI). Whilst receipt guideline-indicated treatment for AMI associated improved prognosis, extent to which comorbidities influence provision its efficacy unknown. Therefore, we investigated association between survival seven comorbidities. Methods We used data 693,388 recorded in Myocardial Ischaemia National Audit Project (MINAP), 2003–2013. optimal...

<h3>Purpose</h3> To investigate the intraocular pressure (IOP) lowering mechanisms of deep sclerectomy (DS) with anterior segment optical coherence tomography (AS-OCT). <h3>Methods</h3> In a prospective cross-sectional study, AS-OCT parameters were compared between DS, trabeculectomy and control cases. Association IOP success (IOP≤16 mm Hg without medication) was investigated. <h3>Results</h3> 18 DS (15 patients), 17 (16 patients) 15 controls examined. Successful had taller intrascleral lake...

Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability human longevity and healthy aging. Here, we show no robust association between common variants mtDNA frailty (an "unhealthy aging" phenotype) or mortality in 700, more than 85-year-old, participants Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently compelling link inherited

<h3>Background</h3> People aged 85 years and older are the fastest growing age group worldwide. This study assessed respiratory health, prevalence of disease use spirometry in diagnosis a population-based cohort year olds to better understand health this sector society. <h3>Methods</h3> A single birth-cohort participated assessment at their home or residential institution including self-reporting symptoms measurement spirometry. General practice medical records were reviewed for diagnoses...

Background and objective The impact of the COVID-19 pandemic on quality care for patients with acute myocardial infarction (AMI) is uncertain. We aimed to compare AMI in England Wales during before using 2020 European Society Cardiology Association Acute Cardiovascular Care indicators (QIs) AMI. Methods Cohort study linked data from percutaneous coronary intervention registries between 1 January 2017 27 May (representing 236 743 186 hospitals). At patient level, likelihood attainment each QI...

Objective International studies report a decline in mortality following ST-elevation myocardial infarction (STEMI). The extent to which the observed improvements STEMI survival are explained by temporal changes patient characteristics and utilisation of treatments is unknown. Methods Cohort study using national registry data from Myocardial Ischaemia National Audit Project between first January 2004 30th June 2013. 232 353 survivors hospitalisation with as recorded 247 hospitals England...

Objective To describe, using data from the Newcastle 85+ cohort study, use of primary care and other healthcare services by 85-year-olds as they age. Design Longitudinal population-based study. Setting on Tyne North Tyneside, UK. Participants Community dwelling institutionalised men women recruited through general practices (n=845, 319 526 women). Results Contact was established with 97% (n=1409/1459) eligible 85-year-olds, consent obtained 74% (n=1042/1409) 851 agreed to undergo...

Background: Low serum thyrotropin (TSH) has been associated with an increased risk of cognitive impairment in observational studies older individuals, but the mechanism underlying this is unclear. We investigated association between changes thyroid status and very old adults, using prospective data from Newcastle 85+ study. Method: A cohort 85-year-old individuals was assessed for health function. Complete a comprehensive multidimensional measure repeat function were available 642...

People with serious mental illness (SMI) experience higher mortality partially attributable to long-term condition (LTC) prevalence. However, little is known about multiple LTCs (MLTCs) clustering in this population.People from South London SMI and two or more existing aged 18+ at diagnosis were included using linked primary healthcare records, 2012-2020. Latent class analysis (LCA) determined MLTC classes multinominal logistic regression examined associations between demographic/clinical...

Abstract Background it is not known if clinical practice reflects guideline recommendations for the management of hypertension in older people and whether adherence varies according to overall health status. Aims describe proportion attaining National Institute Health Care Excellence (NICE) blood pressure targets within 1 year diagnosis determine predictors target attainment. Methods a nationwide cohort study Welsh primary care data from Secure Anonymised Information Linkage databank...

Abstract Background Quality indicators (QIs) have been increasingly used as tools to assess and improve the quality of care for acute myocardial infarction (AMI). However, it is not known if feasible use 2020 iteration international AMI QIs using routinely collected data and, so, whether higher performance associated with improved outcomes. Objective To investigate routine are available measure against European Society Cardiology (ESC) Association Acute Cardiovascular Care (ACVC) AMI,...

Abstract Background At least 10 million people in Europe have a diagnosis of atrial fibrillation (AF). People with AF commonly concomitant frailty, rendering them vulnerable to various adverse outcomes. Whilst appropriate prescription oral anticoagulation (OAC) is associated reduced risk stroke and mortality, there are fears iatrogenic harm older frailty. Purpose Previous studies give conflicting evidence the association between frailty OAC based on small samples from select cohorts....

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)