A5101553001- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Machine Fault Diagnosis Techniques
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Optical Coherence Tomography Applications
- Non-Destructive Testing Techniques
- Systemic Lupus Erythematosus Research
- Vehicle License Plate Recognition
- Infrastructure Maintenance and Monitoring
- Health Systems, Economic Evaluations, Quality of Life
- Pituitary Gland Disorders and Treatments
- Fault Detection and Control Systems
- Structural Health Monitoring Techniques
- Pharmaceutical Economics and Policy
- Railway Engineering and Dynamics
- Acute Ischemic Stroke Management
- Teratomas and Epidermoid Cysts
- Cervical and Thoracic Myelopathy
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Peking Union Medical College Hospital
2017-2024
Fuzhou Second Hospital
2024
Huawei Technologies (Germany)
2024
University of Birmingham
2022-2023
Chinese University of Hong Kong, Shenzhen
2022
Shenzhen Academy of Robotics
2022
University of Leicester
2018-2020
University of Lusaka
2020
Ophthalmology Associates (United States)
2017-2020
Prior trials with monoclonal antibodies to proprotein convertase subtilizin/kexin type 9 (PCSK9) reported robust low density lipoprotein cholesterol (LDL-C) reductions. However, the ability detect potentially beneficial changes in other lipoproteins such as (a), triglycerides, high-density (HDL-C), and apolipoprotein (Apo) A1, adverse events (AEs) was limited by sample sizes of individual trials. We report a pooled analysis from four phase 2 studies evolocumab (AMG 145), antibody PCSK9.The...
Aims To investigate the efficacy of a bi-modality deep convolutional neural network (DCNN) framework to categorise age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) from colour fundus images optical coherence tomography (OCT) images. Methods A retrospective cross-sectional study was proposed patients with AMD or PCV who came Peking Union Medical College Hospital. Diagnoses all were confirmed by two retinal experts based on diagnostic gold standard for PCV....
Background/aims The aim of this study was to generate and evaluate individualised post-therapeutic optical coherence tomography (OCT) images that could predict the short-term response antivascular endothelial growth factor therapy for typical neovascular age-related macular degeneration (nAMD) based on pretherapeutic using generative adversarial network (GAN). Methods A total 476 pairs OCT patients with nAMD were included in training set, while 50 tests set retrospectively, their...
Purpose: To develop deep learning models based on color fundus photographs that can automatically grade myopic maculopathy, diagnose pathologic myopia, and identify segment myopia-related lesions. Methods: Photographs were graded annotated by four ophthalmologists then divided into a high-consistency subgroup or low-consistency according to the consistency between results of graders. ResNet-50 network was used classification model, DeepLabv3+ segmentation model for lesion identification. The...
Abstract Background To investigate alterations in retinal microvasculature eyes with preclinical diabetic retinopathy (DR) using ultra-wide field swept-source optical coherence tomography angiography (UWF SS OCTA). Methods Prospective cross-sectional study. Fifty-five of 30 patients without clinical signs were included. All subjects underwent OCTA examination a 12 × mm 2 view 5 visual fixations (1 central fixation and 4 peripheral fixations) to compose UWF image. In the images, area...
Suspension systems are significant for safe and comfort operation of high-speed trains. Health assessment is a useful tool to schedule maintenance plans suspension systems, furthermore ensure safety railway transportation. In real operating condition, two problems, i.e. data imbalance shortage labelled data, result in difficult health the system using deep learning. this work, multi-sensor information fusion method, called as graph transfer network (MSGTN), proposed basis learning neural...
Purpose To assess the retinal vasculature changes quantitatively using wide-field optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE), and explore its correlation with clinical features. Design Prospective, cross-sectional, observational study. Participants controls Patients SLE who presented to Ophthalmology Department of Peking Union Medical College Hospital from November 2022 April 2023 were collected. The subjects divided into retinopathy without groups....
The aim of this study was to compare the repeatability optical coherence tomography angiography (OCT-A) measurements macular vessel density using four OCT-A systems, including Heidelberg Spectralis HRA, Optovue RTVue XR, Zeiss Cirrus HD-OCT 5000, and Topcon DRI OCT Triton. A cross-sectional design used for study. vascular length superficial deep retinal capillary plexuses were imaged with 3 mm 6 scan patterns calculated ImageJ. Comparisons intraclass correlation coefficients (ICC) conducted....
Defective droppers pose a significant threat to the performance of contact between train pantograph and railway catenary. In this paper, impact damaged on pantograph–catenary interaction behaviour is analysed, varying degrees damage each dropper labelled. To improve classification accuracy when both degree position are considered, model integrating multiple 1D CNNs proposed. Approaches including randomly searching optimal hyper-parameters K-fold cross-validation used prevent overfitting...
To investigate subfoveal choroidal thickness and pachychoroid their correlation with hormone level in patients endogenous Cushing syndrome (CS).We enrolled a consecutive series of CS healthy controls. All participants had swept-source optical coherence tomography. test including morning plasma-free cortisol, 24-hour urine-free cortisol (24UFC), plasma adrenocorticotropic hormone. We compared changes between two groups. performed univariate multivariate analysis to study choroid as well...
To compare the qualitative and quantitative features among untreated polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nv-AMD) central serous chorioretinopathy (CSC) using optical coherence tomography (OCT) OCT angiography (OCTA).This retrospective study included 16 eyes with thin-choroid PCV, 18 thick-choroid nv-AMD 17 CSC, respectively. The indicators were obtained by OCTA.Sub-foveal thickness (SFCT) in CSC was thicker compared to other groups (all...
Abstract Background To investigate swept-source optical coherence tomography angiography (SS-OCTA) for deep choroid visualization and choroidal vascular density (CVD) measurement. Methods Healthy subjects central serous chorioretinopathy (CSC) patients were recruited macular SS-OCTA scans. We evaluated OCTA images at various depths to determine an optimal depth visualizing vasculatures. measured CVD with binarized the depth. In healthy subjects, was studied its correlation age, axial length...