A5010618258- Metal Extraction and Bioleaching
- Extraction and Separation Processes
- Minerals Flotation and Separation Techniques
- Reconstructive Surgery and Microvascular Techniques
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Metallurgical Processes and Thermodynamics
- Nonmelanoma Skin Cancer Studies
- Geological and Geophysical Studies Worldwide
- Mine drainage and remediation techniques
- Arsenic contamination and mitigation
- Head and Neck Cancer Studies
- Virus-based gene therapy research
- Archaeological and Historical Studies
- Esophageal Cancer Research and Treatment
- Vascular Tumors and Angiosarcomas
- Archaeological and Geological Studies
- Mineralogy and Gemology Studies
- Vascular Procedures and Complications
- Crystal Structures and Properties
- Electrochemical Analysis and Applications
- Hippo pathway signaling and YAP/TAZ
Institut d'Investigació Biomédica de Bellvitge
2014-2023
Bellvitge University Hospital
1994-2021
Universitat Internacional de Catalunya
2017
Universitat de Barcelona
2004-2016
Ajuntament de L’Hospitalet
2015
Institut Català d'Oncologia
2015
Charles University
2010
Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumours, which require a complex specialized multidisciplinary management. The diagnostic approach should include imaging studies core needle biopsy performed prior to undertaking surgery. Wide excision is the mainstay treatment for localized sarcoma, associated preoperative or postoperative radiotherapy be administered in high-risk patients. Adjuvant chemotherapy was with modest improvement survival meta-analysis...
Advanced and undifferentiated skin squamous cell carcinomas (SCCs) exhibit aggressive growth enhanced metastasis capability, which is associated in mice with an expansion of the cancer stem-like (CSC) population changes regulatory mechanisms that control proliferation invasion these cells. Indeed, autocrine activation PDGFRα induces CSC promotes distant advanced SCCs. However, involved this process were unclear. Here, we show CSCs mouse SCCs (L-CSCs) express CXCR4 CXCR7, both receptors...
Abstract Malignant peripheral nerve sheath tumors ( MPNST s) are soft‐tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 NF 1). These aggressive malignancies confer poor survival, no effective therapy available. We present the generation and characterization of five distinct orthoxenograft models for preclinical testing personalized medicine. Four patient‐derived tumor xenografts PDTX ), two independent s from same patient different sporadic...
Cancer stem-like cells (CSC) play key roles in long-term tumor propagation and metastasis, but their dynamics during disease progression are not understood. Tumor relapse patients with initially excised skin squamous cell carcinomas (SCC) is characterized by increased metastatic potential, SCC associated an expansion of CSC. Here, we used genetically chemically-induced mouse models to investigate the signaling pathways contributing CSC function progression. We found that regulatory...
Recurrent and/or metastatic unresectable cutaneous squamous cell carcinomas (cSCCs) are treated with chemotherapy or radiotherapy, but have poor clinical responses. A limited response (up to 45% of cases) EGFR-targeted therapies was observed in trials patients advanced and cSCC. Here, we analyze the molecular traits underlying EGFR inhibitors, mechanisms responsible for cSCC resistance therapy.We generated primary cultures patient cSCC-derived xenografts (cSCC-PDXs) that recapitulate...
Sarcomas are uncommon tumors and free-margin surgical resection remains the single most important treatment in curative therapy of soft tissue sarcomas. Refinements techniques have led to increased function preservation limb salvage. <b>Patients Methods</b> The records patients (<i>n</i> = 41) who underwent microsurgical reconstruction subsequent sarcoma during period 1998 2010 were reviewed compared with a general nonmicrosurgery group 188) relation clinicopathological characteristics,...