A5029286344- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Primate Behavior and Ecology
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Animal Behavior and Reproduction
- Animal Vocal Communication and Behavior
- Evolution and Paleontology Studies
- Genome Rearrangement Algorithms
- Forensic and Genetic Research
- Advanced biosensing and bioanalysis techniques
- Animal Ecology and Behavior Studies
- Forensic Anthropology and Bioarchaeology Studies
- Bat Biology and Ecology Studies
- Amphibian and Reptile Biology
- Evolution and Genetic Dynamics
- Pleistocene-Era Hominins and Archaeology
- Plant Virus Research Studies
- Gene expression and cancer classification
- Wildlife Ecology and Conservation
- Plant and animal studies
University of Florence
2014-2023
National Cancer Institute
2000-2009
Minnesota Department of Natural Resources
2007
University of Minnesota
2007
Beijing Normal University
2007
Howard Hughes Medical Institute
2007
University of Washington
2007
Frederick National Laboratory for Cancer Research
2000-2006
Weatherford College
2006
National Institutes of Health
1999-2005
The homology between hylobatid chromosomes and other primates has long remained elusive. We used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the establish homologies human, great ape (chimpanzee, gorilla, orangutan), gibbon karyotypes (Hylobates lar species group, 2n = 44). patterns unequivocally demonstrate high degree synteny chromosomes. Relative no translocations were detected apes, except for well-known fusion-origin chromosome...
Human post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional cells. In this study, we periodontal ligament test the hypothesis that contains retrievable These maintained normal cell characteristics, including expression of mesenchymal surface molecule STRO-1, single-colony-strain generation, multipotential differentiation,...
A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional evolutionary new centromeres (ENCs) for a total nine ENCs. To understand the dynamics ENC formation progression, we compared chromosome 4 with orthologous region, at 6q24.3, that conserves ancestral genomic organization. 250-kilobase segment was extensively duplicated around centromere. These duplications were strictly intrachromosomal. Our results suggest novel may...
The past decade has witnessed an explosion of genome sequencing and mapping in evolutionary diverse species. While full mammals is rapidly progressing, the ability to assemble align orthologous whole chromosome regions from more than a few species still not possible. intense focus on building comparative maps for companion (dog cat), laboratory (mice rat) agricultural (cattle, pig, horse) animals traditionally been used as means understand underlying basis disease-related or economically...
We describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member Old World (OWM) superfamily is uniquely valuable for genetic investigations simian immunodeficiency virus (SIV), which it most abundant natural host species, and wide range health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small their ancestors from West Africa during colonial era. use to...
We employed fluorescence in situ hybridization (FISH) with probes established by flow sorting metaphase chromosomes of the domestic cat (<i>Felis cattus</i>, 2n = 38) to “paint” homologous segments on human and, reciprocally, using chromosome paints feline preparations. The results revealed, direct microscopic observation, widespread conservation genome organization between two mammalian orders and confirmed 90% genes mapped both species. Fourteen 23 chomosomes were hybridized...
Reciprocal chromosome painting between mouse and rat using complete probe sets of both species permitted us to assign the chromosomal homology these rodents. The comparative gene mapping data have a better than 90% correspondence. reciprocal results graphically show that strikingly different karyotypes. At least 14 translocations occurred in 10–20 million years evolution separates two species. evolutionary rate rodents appears be up 10 times greater found humans cats, or chimpanzees, where...
Abstract Background Sirenia (manatees, dugongs and Stellar's sea cow) have no evolutionary relationship with other marine mammals, despite similarities in adaptations body shape. Recent phylogenomic results place Afrotheria elephants rock hyraxes Paenungulata. Hyracoidea are the two afrotherian orders as yet unstudied by comparative molecular cytogenetics. Here we report on chromosome painting of Florida manatee. Results The human autosomal X paints delimited a total 44 homologous segments...
We report on the paleopathological analysis of partial skeleton late Pliocene hominin species Australopithecus africanus Stw 431 from Sterkfontein, South Africa. A previous study noted presence lesions vertebral bodies diagnosed as spondylosis deformans due to trauma. Instead, we suggest that these are pathological changes initial phases an infectious disease, brucellosis. The macroscopic, microscopic and radiological appearance lytic lumbar vertebrae is consistent with hypothesis...