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- Osteoarthritis Treatment and Mechanisms
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University of California, San Diego
2005-2025
University of the Western Cape
2023-2024
University of Birmingham
1995-2019
University of Louisville Hospital
2014-2015
Hospital for Special Surgery
2011-2012
Fowler Kennedy Sport Medicine Clinic
2012
La Jolla Alcohol Research
2012
University of California, San Francisco
2012
University of Pittsburgh
2012
National Institutes of Health
2006
Background: Fresh-stored osteochondral allografts have been used successfully to resurface large chondral and defects of the knee. However, there are limited data available for return athletic activity. Purpose: To review rate activity after allograft transplantation in knee identify any potential risk factors not returning sport. Study Design: Case series; Level evidence, 4. Methods: Forty-three athletes were treated with fresh-stored symptomatic or from 2000 2010. The average age (30 men,...
Symptomatic labral tears of the hip are associated with bony abnormalities femoral head and acetabulum, resulting in impingement. These patients have characteristic internal rotation limitations, which can result compensatory athletic injury patterns around hip, pelvis, lumbar spine.Patients undergoing arthroscopic cam decompression will improvement after decompression. Patients decreased neck anteversion preoperative show less decompression.Cohort study; Level evidence, 3.Patients pincer...
Despite improvements in arthroscopic rotator cuff repair technique and technology, a significant rate of failed tendon healing persists. Improving the biology repairs may be an important focus to decrease this failure rate. The objective study was determine mRNA biomarkers histological characteristics repaired cuffs that healed or developed persistent defects as determined by postoperative ultrasound.Increased synovial inflammation degeneration at time surgery are correlated with...
Background and objectives Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through introducing needle followed by delivery electric current. This has been reported to treat chronic pain as well postoperative following knee foot surgery. However, it remains unknown if this technique may be used in ambulatory patients upper extremity The purpose proof-of-concept study was investigate various implantation locations evaluate feasibility...
<b>Objective:</b> The purpose of this prospective proof concept study was to investigate the feasibility using percutaneous peripheral nerve stimulation femoral treat pain in immediate postoperative period following ambulatory anterior cruciate ligament reconstruction with a patellar autograft. <b>Materials and Methods:</b> Preoperatively, an electrical lead (SPRINT, SPR Therapeutics, Inc., Cleveland, OH, USA) percutaneously implanted ultrasound guidance caudad inguinal crease. Within...
To date, the morphological, biochemical, and biomechanical characteristics of articular cartilage in osteochondral allografts that have been stored not fully described.Osteochondral procured commercially for a standard period as determined by tissue banking protocol will compromised chondrocyte viability but preserved extracellular matrix quality.Controlled laboratory study.Unused from 16 consecutive was sampled during surgery after bank processing storage. Ten grafts were examined cell...
Abstract Background The flexor pronator mass (FPM) is an important dynamic stabilizer to valgus stress at the elbow and has been reported protect against ulnar collateral ligament (UCL) injury. Active gripping pronation have demonstrated reduced ulnohumeral joint space change in material properties of UCL when examined vivo via ultrasound. No studies utilized ultrasonography shear wave elastography characterize medial elbow’s response FPM activation under stress. This cross-sectional,...
Osteochondral plugs were harvested from eight fresh human femoral condyles within 96 hours of donor death. The either stored in a serum-free media containing glucose, salts, and amino acids or 10% fetal bovine serum at 4°C. After 28 days storage, the osteochondral analyzed for chondrocyte viability viable cell density using confocal microscopy, proteoglycan synthesis by 35SO4 incorporation, glycosaminoglycan content. Chondrocyte significantly lower grafts compared to serum, 27% versus 68% (P...
Pregnancy is associated with a physiological increase in coagulation factors and heparin binding proteins; both can affect the activated partial thromboplastin time (APTT) response to unfractionated (UFH) invalidating use of non-pregnant APTT therapeutic range. We compared anticoagulant UFH added vitro plasma 13 pregnant (third trimester) 15 nonpregnant women determine whether measured antifactor Xa activities are lower pregnancy. Increasing concentrations were platelet-poor from each...
Anterior cruciate ligament (ACL) reconstruction is one of the most common procedures performed by orthopedic surgeons. While autograft remains gold standard, allograft tissues have become a controversial option for ACL reconstruction. No data currently exist regarding recent trends in graft choices, and no consensus exists over which type appropriate patient. In this article, we examine choice at our institution, review pertinent information surgeon must consider when making decision. We...
Abstract Objective To determine expression patterns of apoptotic and matrix‐degrading genes during aging development osteoarthritis (OA), using a rabbit model induced OA. Methods Six mature 6 aged rabbits underwent anterior cruciate ligament transection were killed 4 8 weeks after surgery, respectively, to create early‐grade advanced‐grade RNA from articular cartilage menisci was examined for the caspase 8, Fas, Fas ligand, p53, aggrecanase, matrix metalloproteinase 1 (MMP‐1), MMP‐3. A...
The Celtic and the Roman Churches have both left their mark broad deep on place-names of Scotland.The Kirks Kils, numerous though names are that they help to form, constitute but a small part whole.Many names, such as St. Andrews, Boswells, Fillans, either lost or never had attached them terms Kil Kirk.A considerable number associated under one other her designations with Virgin Mary, Kilmuir, Maryculter, Ladybank, Motherwell.The many places contain words chapel, cross, hospital spittal,...
We identified changes in proapoptotic and extracellular matrix-related gene expression with prolonged storage of fresh osteochondral allografts using array analysis to better understand the process graft degradation during storage. Six human distal femurs were obtained according standard organ harvesting protocol stored serum-free allograft media. Each was examined at baseline (within 72 hours postmortem), 21 days (average time implantation), 35 (maximum implantation) for two 100-gene...
Background Osteochondral allografts currently are hypothermically stored for a minimum of 14 days to maximum 28 before surgical implantation, making storage conditions increasingly important. Previous studies have suggested that graft deterioration during may result from degradative factors and residual marrow elements in the subchondral bone. Hypothesis Allografts with large bone-to-cartilage ratios will be compromised after prolonged compared grafts minimal Study Design Controlled...
Most current efforts to enhance critical thinking focus on skills practice and training. The empirical research from the fields of cognition affect sciences suggest that positive mood, even when transiently induced, can have beneficial effects cognitive flexibility problem solving. We undertook this study test hypothesis in a practical setting. Using an A-B-A-B within subject design, we measured impact (versus neutral) mood demonstrated four essay exams undergraduate course personality....
The educational record of Catholic schools has been a cause for popular concern some time, but very little hard evidence is available to support the partisans in public debate. Using data about experience male adults Scotland, this paper shows that, while differences do exist at both secondary and post-secondary levels, these have not great, certainly as great seems be generally believed. When one controls social class, inter-religion difference among children from non-manual families...