A5087329109- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Protein purification and stability
- SARS-CoV-2 and COVID-19 Research
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Response and Inflammation
- Immune Cell Function and Interaction
Oslo University Hospital
2024
University of Oslo
2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022-2024
RNA vaccines are efficient preventive measures to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. High levels of neutralizing SARS-CoV-2 antibodies an important component vaccine-induced immunity. Shortly after initial two mRNA vaccine doses, immunoglobulin G (IgG) response mainly consists proinflammatory subclasses IgG1 and IgG3. Here, we report that several months second vaccination, SARS-CoV-2–specific were increasingly composed noninflammatory IgG4,...
Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter optimization challenge known as "developability", which reflects an antibody's ability to progress through development stages based on its physicochemical properties. While natural antibodies may provide valuable guidance for mAb selection, we lack comprehensive understanding of developability parameter (DP) plasticity (redundancy, predictability, sensitivity) and how the DP landscapes human-engineered relate...
Abstract Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter optimization challenge known as “developability”, which reflects an antibody’s ability to progress through development stages based on its physicochemical properties. While natural antibodies may provide valuable guidance for mAb selection, we lack comprehensive understanding of developability parameter (DP) plasticity (redundancy, predictability, sensitivity) and how the DP landscapes...
Abstract Repeated mRNA vaccinations are an efficient tool to combat the SARS-CoV-2 pandemic. High levels of neutralizing SARS-CoV-2-antibodies important component vaccine-induced immunity. Shortly after first or second vaccine dose, IgG response mainly consists pro-inflammatory isotypes IgG1 and IgG3 is driven by T helper (Th) 1 cells. Here, we report that several months vaccination, SARS-CoV-2-specific antibodies were increasingly composed non-inflammatory IgG2 particularly IgG4, which...