A5008400793- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Nanowire Synthesis and Applications
- ATP Synthase and ATPases Research
- Diet and metabolism studies
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Heat shock proteins research
University of California, Los Angeles
2024
Centro de Investigaciones Biológicas Margarita Salas
2012-2023
Abstract A major limitation to developing chimeric antigen receptor (CAR)-T cell therapies for solid tumors is identifying surface proteins highly expressed in but not normal tissues. Here, we identify Tyrosinase Related Protein 1 (TYRP1) as a CAR-T therapy target treat patients with cutaneous and rare melanoma subtypes unresponsive immune checkpoint blockade. TYRP1 primarily located intracellularly the melanosomes, small fraction being trafficked via vesicular transport. We develop...
The uncoupling protein UCP2 is a mitochondrial carrier for which transport activity remains controversial. physiological contexts in expressed have led to the assumption that, like UCP1, it uncouples oxidative phosphorylation and thereby reduces generation of reactive oxygen species. Other reports involved Warburg effect, results showing that catalyzes export matrix C4 metabolites facilitate glutamine utilization suggest could be metabolic adaptations required cell proliferation. We examined...
Abstract The uncoupling protein UCP2 is a mitochondrial carrier whose transport activity remains controversial. physiological contexts in which expressed have led to the assumption that, like UCP1, it uncouples oxidative phosphorylation and as result lowers generation of reactive oxygen species. Other reports involved Warburg effect results showing that catalyzes export matrix C4 metabolites facilitate glutamine utilization, suggests could be metabolic adaptations required for cell...