A5025040509- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Glioma Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
- Growth Hormone and Insulin-like Growth Factors
- Kruppel-like factors research
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Cancer Genomics and Diagnostics
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
- Ion channel regulation and function
- Galectins and Cancer Biology
- Chronic Myeloid Leukemia Treatments
United Arab Emirates University
1996-1997
Institute of Psychiatry and Neurology
1993-1996
Psychiatry Research Trust
1994-1995
Instituto Superior da Maia
1995
Institut Curie
1992
Centre National de la Recherche Scientifique
1992
Abstract The mechanisms underlying the invasive properties of glio‐mas, major form intrinsic brain tumours in humans, are poorly understood. We have reported that CD44 plays an important role this behaviour vitro . In present work, we investigated its ligand, hyaluronic acid (HA), invasion 8 human glioma cell lines. found HA mediates detachment via interaction with high affinity receptor, CD44H. Using μm porosity polycarbonate filter transwells, demonstrate strongly stimulates migration all...
AbstractAdhesion of eight cell lines, derived from human gliomas different histological types, to fibronectin, collagen I, vitronectin, and laminin was investigated in vitro. The glioma lines were found attach these substrates extents. Interestingly, all strongly attached laminin. In addition, adhesion be dose dependent. Moreover, three fibronectin I partially inhibited vitronectin completely prevented by GRGDTP peptide, indicating the involvement integrin receptors adhesion. We have...
Invasion of the reconstituted extracellular matrix composite, Matrigel, by eight human glioma–derived cell lines and fetal brain cells was assessed in vitro using 8 um polycarbonate filters a modified Boyden migration chamber. With exception one low grade glioma derived line, all studied proved to be invasive while normal failed invade. This potential independent histological tumour from which originated. In addition, expression metastasis–associated gene 18A2lmts1 as well tissue inhibitor...
TGF-beta 1 stimulates thymidine incorporation and the growth rate of mouse NIH3T3 fibroblasts those cells transformed by EJ-H-ras oncogene (TR15 cells), in presence absence serum. Thymidine incorporation, serum-deprived cells, is stimulated to a higher degree 0.1-1 ng/ml than TR15 which have 10-fold basal level incorporation. In both cell types as active, or more active other mitogens (TGF-alpha, PDGF-AB, bFGF) at same concentration. The low serum serum-free (S-) medium, only 10 picograms/ml...
Gliomas constitute more than 50% of primary brain tumours in man. Perhaps the most important hallmark these is their diffuse invasion normal structures. The biological factors involved control both proliferation and are, however, not well known. We studied expression receptors for epidermal growth factor (EGF), basic fibroblast (bFGF), platelet derived (PDGF), transforming beta-1 (TGF-beta 1) low grade astrocytoma (IPNT-H)-, III (IPSB-18)-, glioblastoma (IPRM-5)- cell lines. effects EGF,...
TGF-β1 stimulates thymidine incorporation and the growth rate of mouse NIH3T3 fibroblasts those cells transformed by EJ-H-ras oncogene (TR15 cells), in presence absence serum. Thymidine incorporation, serum-deprived cells, is stimulated to a higher degree 0.1-1 ng/ml TGF-β than TR15 which have 10-fold basal level incorporation. In both cell types as active, or more active other mitogens (TGF-α, PDGF-AB, bFGF) at same concentration. The low serum serum-free (S−) medium, only 10 picograms/ml...