To study clinical and immunological relationships in patients with early schizophrenia during remission. Forty-eight (53% females 47% males) were examined at the initial stage of remission (age 28.3±5.8 years). The duration disease was 2.7±1.3 years. control group consisted healthy males aged 18 to 30 used clinical-psychopathological laboratory methods, as well scale assessment. In remission, 70% cases, there an increase blood levels cytokines IL-6, IL-9, IL-10, IL-13, IL-22, TNF-α,...

Several studies have demonstrated that local ischemic preconditioning can reduce myocardial ischemia-reperfusion injury in cardiac surgery patients; however, has not become a standard cardioprotective intervention, primarily because of the increased risk atheroembolism during repetitive aortic cross-clamping. In present study, we aimed to describe and validate novel technique induction.Patients undergoing coronary artery bypass grafting (12 women 78 men; mean age, 56 ± 11 years) were...

Modern data on the role of vitamin B12, and its biologically active form holotranscobalamin in particular, development anemia pregnancy are presented. Information B12 metabolism coupling with folic acid homocysteine is supplied. The new automated immunochemiluminescent method for determination described. Reference intervals related indices that can be used differential diagnosis specified.

The publication provides the latest data on problem of drug liver disease, particularly during pregnancy. Classification diseases, selected risk factors, mechanisms damage and laboratory tests are described. Physiological changes in function pregnancy that must be considered diagnosis disease outlined.

Background. Percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) is followed often by myocardial injury. Up to now there no mutual agreement the infl uence of perioperative injury on long-term prognosis IHD patients. Objective. The aim study was assess risk factors for development cardiac events period stable artery damage after PCI. Materials and methods . included 113 who underwent planned Serum troponin levels were determined before 24 hours intervention....

Patients with ischemic heart disease undergoing percutaneous coronary intervention are characterized by various degrees of myocardial damage.The purpose the study is to investigate dependence micro-injuries myocardium on nature damage arteries and features procedure during interventional treatment in patients stable angina.Myocardial was diagnosed based dynamics cardiospecific biomarkers creatine kinase-myocardial band isoenzyme before 24 hours after intervention.Providing analysis...

The aim of this work was to study the availability vitamin D in population free living elderly people St. Petersburg and its relationship with laboratory indicators risk cardiovascular complications. In winter were surveyed 209 volunteers who did not take during previous 6 months, 152 women 57 men aged 71 91 years. all examined patients concentration D(OH) serum below 30 ng/ml (analyzer reagents «Architect i1000SR, Abbott»). No significant mutual effects found between level 25(OH)D lipid...

Despite the existence of Russian Consensus on gestational diabetes mellitus (GDM) since 2012 in Federation, its implementation into clinical practice has been slow, partially because creation took place without participation laboratory services. In this review issues preanalytical and analytical considerations such tests as blood glucose test, oral tolerance test (OGTT), glycosylated hemoglobin are discussed. If presence prandial hyperglycemia from 5.1 to 5.6 mmol/l is identified, testing...

The review presents the criteria of vitamin A deficiency D adopted by in different countries and approaches to appointment during pregnancy. Analyzed data from most important studies recent years devoted this problem.

Electroconvulsive therapy (ECT) is considered an effective and safe treatment. However, the possibility of cognitive adverse effects has raised a question about neuronal damage. Neuron-specific enolase (NSE) S100b protein (S100b) were measured to determine whether ECT induces injury or glial activation. C-reactive (CRP), creatine phosphokinase (CPK) CPK-MB levels also measured. Present study was conducted in 14 patients with treatment-resistant schizophrenia (29,4±7,7 years old) that...

One of the major problems methodology translational research is to find biomarkers that serve as indicators treatment response. The aim was study dynamics biochemical markers in process combined antipsychotics and electroconvulsive therapy. Material methods Present conducted 34 patients with treatment-resistant schizophrenia (31.6±9.4 years old) underwent ECT (10 ECTs on average) pharmacological treatment. assessment included PANSS determination NSE S100B protein concentrations using...

Diagnostic and therapy monitoring prospectives challenges with pregnant women of different gestational age have been analysed reviewed. The advanced laboratory techniques for the prediction preeclampsia fetal growth restriction, as well such biomarkers placental factor, neutrophil gelatinase-associated lipocalin, holotranscobalamin, 25-hydroxyvitamin D, B-type natriuretic peptide cardiac troponin I are discussed.).

Background. High levels of cardiac troponin in the blood indicates myocardial injury, including those caused by intense exercises. Recent studies have shown that an elevation concentration patients can be macrotroponin circulation. There is no data scientific literature describing this problem athletes. The aim. To identify cases and possible causes high markers athletes before after endurance Materials methods. study was conducted on 11 male cross-country skiers aged 15–21 years. included...

Objective. To compare the effect of torasemide (Td) and furosemide (Fd) on daily blood pressure profile (DBPP), (BP) during aclive orthostatic test (OT) dynamics in brain natriuretic peptide (BNP) levels patients with heart failure (HF) III-IV (NYHA). Design methods. 40 stable HF (NYHA); left ventricular ejection fraction (LVEF) ≤ %; 90 systolic BP 140 mmHg; 60 diastolic mmHg were included. Clinical status, 6-minute walking (SWT), BNP aldosterone levels, quality live (QL), DBPP, OT assessed....

The article is devoted to the problem of search biomarkers suicidal behavior and includes literature review, as well results own research features young age patients with depression (18—27 years) depending on concentration calcidiol.

A blood test for vitamin D(OH) reflects a person's overall health. Athletes in the winter season have sharp decrease concentration of calcitriol blood. Taking cholecalciferol by athletes at dose 2000 IU per day allows one to maintain levels sufficient level body, which contributes maintaining good physical shape and improving athletic performance. Level 25(OH) analysisD elite is useful monitoring correcting intake D preparations, requires mandatory implementation medical biological support...

The study analysed the level of troponin I (Tn) in blood patients with coronary artery disease after bypass grafting comparison aortic valve replacement surgery. dynamics early postoperative period was studied, a parallelism established between occurrence complications surgery and degree myocardial damage. A new method has been developed for assessing intraoperative damage risk using «index damage», Tn is determined twice operation, up to 6 hours – 12–24 later late, index calculated as ratio...