Background This study used individual-level linked data across general practice, emergency departments (EDs), outpatients and hospital admissions to examine contacts settings time by sex for self-harm in individuals aged 10–24 years old Wales, UK. Methods A whole population-based e-cohort of routinely collected healthcare was conducted. Rates over were examined. Individuals categorised based on the service(s) which they presented. Results total 937 697 contributed 5 369 794 person from 1...

Abstract Background Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance prevent relapse. Most data supporting ketamine refers the intravenous route of administration, leaving alternative routes lacking in data, especially as regimens. Moreover, safety poorly defined. This report aims describe and evaluate novel hospital-to-outpatient intranasal racemic program. Methods was an...

This study used ecological momentary assessment (EMA) to explore the correlates of suicidal ideation (SI) instability in patients hospitalized for depression and SI. Thirty-nine adult inpatients were given smartphones with visual analogue scales rate current depressed mood, anger/irritability, feeling socially connected, SI three times a day throughout hospitalization. Affective Lability Scales (ALS) also completed at baseline. was correlated intensity, mood instability, social connection...

Impulsivity, the tendency to act quickly without adequate planning or concern for consequences, is a commonly cited risk factor suicidal thoughts and behaviour. There are many definitions of impulsivity how it relates suicidality not well understood. Mood instability, which describes frequent fluctuations mood over time, concept related that may help explain this relationship. The purpose study was determine whether could predict after controlling instability.This utilized longitudinal data...

The objective of this study was to determine whether affective instability predicts suicidal thoughts. Data from a Dutch panel (N = 1686) used. Affective assessed with 7 items representing suddenly shifting moods. Suicidal thoughts were by the occurrence in past week. Negative affect indexed anxious, depressed and angry moods extracted factor analysis. Odds ratios using logistic regression modeling calculated, adjusting for clinical demographic variables. found that both males (OR: 1.14; 95%...

Background Community studies have found a relatively high prevalence of hallucinations, which are associated with range (psychotic and non-psychotic) mental disorders, as well suicidal ideation behaviour. The literature on hallucinations in the general population has largely focused adolescents young adults. Aims We aimed to explore psychopathologic significance across adult lifespan. Method Using 1993, 2000, 2007 2014 cross-sectional Adult Psychiatric Morbidity Survey series ( N = 33 637),...

The purpose of this study was to determine whether mood instability in people with anxiety disorders contributes trait impulsivity, non-suicidal self-injury, and binge eating/purging.Data were analysed from a general population sample 7,221 adults (Mage = 51.0 years; 56.9% female). Logistic regression analyses effect decompositions used establish the associations five (generalized disorder, social phobia, panic agoraphobia, obsessive-compulsive disorder) eating/purging, then extent that...

Background Neuroticism has often been linked to suicidal thoughts and behaviour. Aims To examine whether neuroticism is associated with suicide deaths after adjusting for known risks. Method UK Biobank participants ( n = 389 365) were assessed as well social, demographic health-related variables at study entry followed up 10 years. Suicide risk was modelled using Cox regression stratified by gender. Results increased the of in both men (hazard ratio (HR) 1.15, 95% CI 1.09–1.22) women (HR...

Impulsivity and affective instability are related traits known to be associated with nonsuicidal self-injury, although few longitudinal studies have examined this relationship. The purpose of study was determine if impulsivity predict future self-injury in the general population while accounting for overlap between these traits. Logistic regression analyses were conducted on data from 2344 participants who completed an 18-month follow-up 2000 British National Psychiatric Morbidity Survey....

Abstract Objective Mendelian randomization studies report a bi‐directional relation between cigarette smoking and mental disorders, yet from clinical standpoint, disorders are the focus of treatment. Here, we used an event history framework to understand their evolution in life course. Our objective was estimate relative contribution genetic predispositions self‐reported status (never, former, present smoker) hospitalizations for major depression, bipolar disorder, schizophrenia. Methods We...

Objective: Obsessive-Compulsive Disorder (OCD) and Personality (OCPD) have been reported to be associated with mood instability (MI), depression suicide-related outcomes. We examined whether obsessive-compulsive symptoms personality traits as well obsessional thoughts of death, are suicidal thoughts, non-suicidal self-injury attempted suicide. Methods: used data from 7,839 people the 2000 British Adult Psychiatric Morbidity Survey that elicited OCD a computerized version Clinical Interview...

There is a well-established inverse relationship between age and positive psychotic symptoms, both in patients with disorders general population samples experiences. The reason for this unclear. We hypothesized that life-course developmental changes borderline personality traits, which also typically decline age, might explain the symptoms.We tested hypothesis data from 19,980 adults who completed 2000, 2007, 2014 UK Adult Psychiatric Morbidity Survey studies. Hallucinations delusions were...

Current descriptions in psychiatry and psychology suggest that depressed mood clinical depression is similar to mild sadness experienced everyday life, but more intense persistent. We evaluated this concept using measures of average instability (MI).We prospectively measured low high moods separate visual analog scales twice a day for seven consecutive days 137 participants from four published studies. Participants were divided into non-depressed group with Beck Depression Inventory score...

This article presents the results of 2 studies that investigated mood instability in Eysenck neuroticism scales and its relationship to trait impulsivity risk taking. In Study 1 we examined between a factor Personality Inventory (i.e., rapid unplanned behavior) general population sample 6,066 adults. The was positively correlated with impulsivity. remaining factors, largely reflecting anxiety, were also impulsivity, although these correlations disappeared when included same regression model....

Most research describing ketamine as a treatment for depression has relied on intravenous dosing. There remains need more to support this with other routes of administration. This was retrospective chart review 30 patients hospitalized unipolar or bipolar treatment-resistant who were treated up four doses compounded intranasal racemic (50 mg 75 mg). Treatment courses lasted 7 days. Symptom improvement measured either the Hamilton Depression Rating Scale Montgomery-Åsberg Scale. Ketamine well...

A pilot study suggested lamotrigine may be more effective for bipolar depression with melancholic features. We tested this hypothesis in a pooled analysis of 5 randomized double-blind placebo-controlled trials acute depression.

In this exploratory pilot study we reanalyzed data from a previous randomized, double-blind, placebo-controlled trial of lamotrigine for bipolar II depression in which was not superior to placebo determine if splitting the sample into melancholic and nonmelancholic subgroups revealed significant treatment effect.Adult outpatients (n = 150) an acute depressive episode completed 8 weeks with (titrated 200 mg/d) or placebo. Depressive symptoms were assessed at baseline weekly 17-item Hamilton...