A5012179903- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Fetal and Pediatric Neurological Disorders
- Bacterial Infections and Vaccines
- Advanced Neuroimaging Techniques and Applications
- Voice and Speech Disorders
- Neurosurgical Procedures and Complications
- Spacecraft and Cryogenic Technologies
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Epilepsy research and treatment
- Glycogen Storage Diseases and Myoclonus
- Spacecraft Design and Technology
- Ocular Diseases and Behçet’s Syndrome
Karolinska Institutet
2013-2024
Karolinska University Hospital
2011-2024
Umeå University
2011-2018
Wesley Hospital
2016
Allen Institute for Brain Science
2016
The University of Queensland
2016
University Hospital of Umeå
2008-2010
Sandvik (Sweden)
2009
St Vincent's Hospital Sydney
2009
<h3>Purpose</h3> The ventral intermediate nucleus of thalamus is the standard target for deep brain stimulation (DBS) in essential tremor (ET). However, favourable data have recently highlighted caudal zona incerta (cZi) as an alternative target. Reports concerning long-term results are however lacking, and we therefore evaluated effects our patients with ET cZi DBS. <h3>Methods</h3> 18 were using Essential Tremor Rating Scale (ETRS) before on-/off-stimulation at 1 3–5 years after surgery...
<i>Background:</i> The posterior subthalamic area (PSA), including the zona incerta and prelemniscal radiation (Raprl), has recently been presented in number of publications as a promising target for deep brain stimulation (DBS) treatment various movement disorders. In order to evaluate safety procedure, we analyzed our initial 40 patients complications side effects. <i>Methods:</i> treated with PSA DBS Parkinson’s disease, essential tremor other forms were included....
The caudal zona incerta (cZi) and posterior subthalamic area (PSA) are an emerging deep brain stimulation (DBS) target for essential tremor (ET).To evaluate the efficacy of control in relation to anatomical locations fields 50 patients with ET DBS cZi.A total 240 contacts were evaluated separately monopolar stimulation, amplitudes optimized improvement hand function. Stimulation fields, i.e., volumes neural activation, simulated each setting assembled into probabilistic maps (PSMs).There...
<b><i>Background:</i></b> Deep brain stimulation (DBS) is a growing treatment modality, and most DBS systems require replacement of the implantable pulse generator (IPG) every few years. The literature regarding potential impact adverse events IPG on longevity treatments rather scarce. <b><i>Objective:</i></b> To investigate incidence events, including postoperative infections, associated with replacements in multicenter cohort....
Fourteen years after shunt implantation, a 26-year-old patient with myelomeningocele, concomitant hydrocephalus and ventriculoatrial cerebrospinal fluid (CSF) presented brief but recurrent episodes of fever predominantly when taking showers or during physical exertion. After 4 inconclusive multidisciplinary investigations, the progressed into end-stage renal disease before an echocardiogram revealed vegetative plaque on tendinous chords tricuspid valve. CSF cultures were grown from valve,...
<b><i>Background:</i></b> Deep brain stimulation (DBS) of the caudal zona incerta (cZi) is a relatively unexplored and promising treatment in patients with severe essential tremor (ET). Preliminary data further indicate that ability to produce language may be slightly affected by treatment. <b><i>Objective:</i></b> To evaluate effects on verbal fluency following cZi DBS ET. <b><i>Method:</i></b> Seventeen consecutive who...
Long-term data on the effects of deep brain stimulation (DBS) for essential tremor (ET) is scarce, especially regarding DBS in caudal Zona incerta (cZi) and posterior subthalamic area (PSA).The aim this prospective study was to evaluate effect cZi/PSA ET at 10 years after surgery.Thirty-four patients were included. All received (5 bilateral/29 unilateral) evaluated regular intervals using rating scale (ETRS).One year surgery, there a 66.4% improvement total ETRS 70.7% (items 1-9) compared...
Deep brain stimulation (DBS) is an established neurosurgical treatment that can be used to alleviate symptoms in essential tremor (ET) and other movement disorders. The aim was develop a method software tool for the prediction of effective DBS electrode contacts based on probabilistic maps (PSMs) patients with ET treated caudal zona incerta (cZi) DBS.A total 33 (37 leads) were evaluated Essential Tremor Rating Scale (ETRS) 12 months after surgery. In addition, hand function (ETRS items 5/6...
Group analysis of patients with deep brain stimulation (DBS) has the potential to help understand and optimize treatment movement disorders. Probabilistic maps (PSM) are commonly used analyze correlation between tissue symptomatic effect but applied different methodological variations.To compute a group-specific MRI template PSMs for investigating impact PSM model parameters.Improvement occurrence dizziness in 68 essential tremor implanted caudal zona incerta were analyzed. The input data...
Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD) and other movement disorders. The ventral intermediate nucleus of the thalamus considered as target choice tremor disorders, including tremor-dominant PD not suitable DBS in subthalamic (STN). In last decade, several studies have shown promising results on from posterior area (PSA), caudal zona incerta (cZi) located posteromedial to STN. aim this study was evaluate long-term effect unilateral cZi/PSA-DBS...
Background The extent of neurodegeneration underlying essential tremor (ET) remains a matter debate. Despite various extents cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity and included limited number patients. Novel automated pipelines allow detailed segmentation lobules based MRI. Objective To compare the volumes in ET patients with those healthy controls (HCs) using an pipeline. Methods Structural MRI scans eligible...
An 18-year-old woman was diagnosed with idiopathic intracranial hypertension (IIH) and bilateral transverse sinus stenoses (TSS), after presenting papilledema decreased visual acuity. Lumbar puncture revealed an opening pressure of >60 cm H 2 O. MRI showed TSS believed to be associated the IIH. Initial treatment consisted symptom relief by a temporary lumbar drain for cerebrospinal fluid (CSF) diversion, while pros cons more permanent solution insertion ventriculoperitoneal shunt (VPS) or...
<b><i>Introduction:</i></b> A wide range of pulse widths (PWs) has been used in globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. However, no specific PW demonstrated clinical superiority, and the paradigm may differ among DBS centers. <b><i>Objective:</i></b> To investigate how different paradigms PWs GPi dystonia affect implantable generator (IPG) longevities energy consumption....
Abstract Individuals with severe and treatment‐resistant obsessive‐compulsive disorder (trOCD) represent a small but severely disabled group of patients. Since trOCD cases eligible for deep brain stimulation (DBS) probably comprise the most end OCD spectrum, we hypothesize that they may be more likely to have strong genetic contribution their disorder. Therefore, while worldwide population DBS‐treated (~300), screening these individuals modern genomic methods accelerate gene discovery in...
Abstract To compare awake and asleep deep brain stimulation (DBS) surgery for Essential Tremor (ET), we conducted this retrospective cohort study of patients consecutively operated with DBS targeting the caudal Zona incerta (cZi). 37 underwent 55 asleep. before on/off one year after were evaluated using Rating Scale (ETRS). Procedural time, electrode localization, parameters adverse events noted compared. ETRS scores similar at baseline between groups except contralateral arm tremor, which...
<b><i>Background:</i></b> Essential tremor (ET) is the most common adult movement disorder. For relatively large group of patients who do not respond adequately to pharmacological therapy, deep brain stimulation (DBS) a well-established treatment option. Most ET will have bilateral symptoms, and many them receive DBS. Unilateral DBS however still procedure, some papers suggest an ipsilateral effect in these patients. <b><i>Objectives:</i></b>...