A5092080829- Glutathione Transferases and Polymorphisms
- Thyroid Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Head and Neck Anomalies
- Cervical Cancer and HPV Research
Shanghai Medical College of Fudan University
2024
Fudan University Shanghai Cancer Center
2023-2024
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Objective To assess the risk factors of cervical lymph node metastasis in elderly patients aged 65 years and older diagnosed with papillary thyroid cancer (PTC). Design method In this retrospective analysis, we included a total 328 PTC. We thoroughly examined clinical features from these patients. Utilizing univariate multivariate logistic regression analyses, aimed to identify contributing central lateral (CLNM/LLNM) specific population PTC older. Results CLNM was significantly associated...
AimsAge is a major risk factor for differentiated thyroid cancer (DTC); however, the mechanisms underlying aging-regulated progression of DTC remains unclear.MethodsBased on multi-omics data (transcriptional files, somatic mutation methylation files) derived from TCGA database, we comprehensively investigated genomic and biological features associated with aging in patients DTC.ResultsWe confirmed that age was an independent overall survival progression-free DTC, 55 years (adopted 8th AJCC...
Abstract Purpose: Medullary thyroid carcinoma (MTC) presents a distinct biological context from other cancers due to its specific cellular origin. This heterogeneous and rare tumor has high prevalence of advanced diseases, making it crucial address the limited therapeutic options enhance complex clinical management. Given accessibility methylation information, we construct largest MTC cohort date. Experimental Design: Seventy-eight fresh-frozen samples constituted our cohort. The...
Background: Metabolic reprogramming is an important hallmark of cancer. Glycolysis provides the conditions on which multiple myeloma (MM) thrives. Due to MM's great heterogeneity and incurability, risk assessment treatment choices are still difficult. Method: We constructed a glycolysis-related prognostic model by Least absolute shrinkage selection operator (LASSO) Cox regression analysis. It was validated in two independent external cohorts, cell lines, our clinical specimens. The also...
<p>Supplementary Methods</p>
<div>AbstractPurpose:<p>Medullary thyroid carcinoma (MTC) presents a distinct biological context from other cancers due to its specific cellular origin. This heterogeneous and rare tumor has high prevalence of advanced diseases, making it crucial address the limited therapeutic options enhance complex clinical management. Given accessibility methylation information, we construct largest MTC cohort date.</p>Experimental Design:<p>Seventy-eight fresh-frozen samples...
<p>List of top 30 differentially methylated regions (DMRs) MTC-C relative to the other two subtypes</p>
<p>Classification and prediction effects of methylation-based MTC clustering system</p>
<p>Classification and prediction effects of methylation-based MTC clustering system</p>
<p>Detailed methylation profile of DMR associated with NNAT</p>
<p>List of top 30 differentially methylated regions (DMRs) MTC-C relative to the other two subtypes</p>
<p>Detailed methylation profile of DMR associated with NNAT</p>
<p>Hyperparameter optimization of elastic net mixing parameter (alpha) in the machine learning model</p>
<p>Hyperparameter optimization of elastic net mixing parameter (alpha) in the machine learning model</p>
<p>Detailed patient information of the MTC methylation cohort</p>
<p>Supplementary Methods</p>
<p>Detailed patient information of the MTC methylation cohort</p>
<div>AbstractPurpose:<p>Medullary thyroid carcinoma (MTC) presents a distinct biological context from other cancers due to its specific cellular origin. This heterogeneous and rare tumor has high prevalence of advanced diseases, making it crucial address the limited therapeutic options enhance complex clinical management. Given accessibility methylation information, we construct largest MTC cohort date.</p>Experimental Design:<p>Seventy-eight fresh-frozen samples...