A5054942601- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Chemical Reactions and Isotopes
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Genital Health and Disease
- Lung Cancer Research Studies
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Amoebic Infections and Treatments
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Digestive system and related health
Centro de Investigación Biomédica en Red de Cáncer
2018-2023
INCLIVA Health Research Institute
2023
Universitat de València
2023
Hospital General Universitario De Valencia
2017-2022
Centro de Investigación Biomédica en Red
2021
Fundacio Investigacio Hospital General Universitari De Valencia
2020
Molecular Oncology (United States)
2019
Antwerp University Hospital
2017-2018
Universitat Politècnica de València
2017
Abstract The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were established, using sphere-forming assays CSC enrichment adherent conditions control counterparts. Patient-derived tumorspheres showed self-renewal unlimited exponential growth...
Background: The human gut harbors around 1013–1014 microorganisms, collectively referred to as microbiota. Recent studies have found that the microbiota may an impact on interaction between immune regulation and anti-cancer immunotherapies. Methods: In order characterize diversity composition of commensal its relationship with response checkpoint blockade (ICB), 16S ribosomal DNA (rDNA) sequencing was performed 69 stool samples from advanced non-small cell lung cancer (NSCLC) patients prior...
Lung cancer is a malignant disease with high mortality and poor prognosis, frequently diagnosed at advanced stages. Nowadays, immense progress in treatment has been achieved. However, the present scenario continues to be critical, full comprehension of tumor progression mechanisms required, exosomes being potentially relevant players. Exosomes are membranous vesicles that contain biological information, which can transported cell-to-cell modulate processes hallmarks cancer. The research aims...
Abstract: Prostate cancer (PCa) is the most common in men. Nowadays, it diagnosed through test of serum prostate-specific antigen (PSA) and rectal examination; however, there still debate about PSA-based diagnosis. Seminal fluid (SF), contains a high concentration subcellular lipid-bound microparticles, traditionally termed “prostasomes”, that are extracellular vesicles (EVs) released into space by prostate gland’s epithelial cells. These vesicles, first described 1982 promote motility sperm...
Despite the success of therapies in lung cancer, more studies new biomarkers for patient selection are urgently needed. The present study aims to analyze role galectin-3 (GAL-3) tumor microenvironment (TME) using tumorspheres as a model and explore its potential predictive prognostic biomarker non-small cell cancer patients. For vitro studies, adenocarcinoma (LUAD) squamous carcinoma (LUSC) primary cultures from early-stage patients commercial lines were cultured, tumorsphere-forming assays...
Background: Identification of activating mutations in the EGFR enabled to change therapeutic approach for NSCLC patients as targets. Liquid biopsy is a new option analysis biomarkers with valuable prognostic and predictive information, allowing detection reproducible minimally invasive approach. The aim this study was correlate mutational status ctDNA at diagnosis follow-up complementary/alternative tissue-based molecular profiling. Methods: Study included 20 EGFR-mutated advanced NSCLC....
Background: Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was characterize CSCs discover new therapeutic strategies. Methods: performed on NSCLC from 8 resected patients 12 cell lines. Suspension cultures (tumorspheres) were established for enrichment differentiated tumor cultured as monolayers (2D). properties tumorspheres assessed vitro vivo....
Background: Exosomes are membranous vesicles around 40-130 nm secreted by cells, carrying key information to distant tissues. have been detected in different types of clinical samples and may play a role NSCLC. They intervene several processes such as angiogenesis, metastatic niche formation, immunosuppression; being relevant stem cell differentiation. The main objective this study was analyze exosomal cargo from NSCLC lines primary cultures under two conditions: suspension with cancer cells...