A5047809217- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Brain Metastases and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Cardiac tumors and thrombi
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- CNS Lymphoma Diagnosis and Treatment
- TGF-β signaling in diseases
INCLIVA Health Research Institute
2017-2024
Universitat de València
2017-2024
Hospital Clínico Universitario de Valencia
2018-2024
Hospital Universitario Fundación Jiménez Díaz
2024
Hospital Universitari i Politècnic La Fe
2014-2022
Centro de Investigación Biomédica en Red de Cáncer
2018-2019
BackgroundA high percentage of patients diagnosed with localized colon cancer (CC) will relapse after curative treatment. Although pathological staging currently guides our treatment decisions, there are no biomarkers determining minimal residual disease (MRD) and at risk being undertreated or even overtreated chemotherapy in this setting. Circulating-tumor DNA (ctDNA) can to be a useful tool better detect relapse.Patients methodsOne hundred fifty CC were prospectively enrolled study. Tumor...
BackgroundLocally advanced head and neck squamous cell carcinoma (LAHNSCC) is a heterogeneous disease in which better predictive prognostic factors are needed. Apart from TNM stage, both systemic inflammation poor nutritional status have negative impact on survival.MethodsWe retrospectively analysed two independent cohorts of total 145 patients with LAHNSCC treated induction chemotherapy followed by concurrent chemoradiotherapy at different academic institutions. Full clinical data,...
Abstract Introduction Molecular-matched therapies have revolutionized cancer treatment. We evaluated the improvement in clinical outcomes of applying an in-house customized Next Generation Sequencing panel a single institution. Methods Patients with advanced solid tumors were molecularly selected to receive molecular-matched treatment into early phase trials versus best investigators choice, according evaluation multidisciplinary molecular tumor board. The primary endpoint was...
The treatment of Ewing Sarcoma family tumors is multimodal, both in children and adults. Axial location metastases are classic prognostic factors. However, the worse prognosis older patients more controversial.Retrospective analysis was performed pediatric adult treated with 2001 SEOP protocol: 6 cycles VIDE chemotherapy (CT). If no progression observed, local (surgery and/or radiotherapy) consolidation treatments were adjusted to prognosis: 8 VAC standard-risk or 1 cycle high-dose CT...
Intraperitoneal (i.p.) chemotherapy improves survival in optimally debulked ovarian cancer patients. However, the need for inpatient administration and perceived higher toxicity rates compared with standard intravenous have limited its widespread application. Several modified outpatient schemes, such as Spanish Ovarian Cancer Research Group (GEICO) regimen, been tested reported overall better tolerance an improvement completion treatment rates. The aim of our study was to assess GEICO...
<b><i>Background:</i></b> Cardiac metastases from papillary thyroid carcinoma are very uncommon. Their incidence is rising due to improvements in survival and diagnosis; nevertheless, our patient the fourth case reported up date. There no clinical trials available this scenario. Therefore, treatment choice made based on experience reports; notably, largest report series was prior approval for using tyrosine-kinase inhibitors cancer....
Adjuvant chemoradiotherapy (CRT) improves relapse-free (RFS) and overall survival (OS) in patients with resected gastric cancer. However, difficulties standardizing an optimal surgical approach a perceived higher toxicity compared the perioperative have limited its widespread application Europe. The aim of our study was to assess long-term outcomes adjuvant CRT at institution.A retrospective review (September 2001-January 2012) completed cancer who received (Macdonald regimen). Adverse...
e15159 Background: Sorafenib improves overall survival (OS) in patients (pts) with advanced hepatocellular carcinoma (HCC). An elevated baseline NLR has been reported as a possible poor prognostic factor several tumors, including HCC. Early-onset toxicity sorafenib also linked better prognosis. Methods: Retrospective review of sorafenib-treated pts (2008-2014). Baseline NLR, toxicity, early rates (onset 1st 30 days), progression-free (PFS) and OS were assessed. Univariate multivariate...
Abstract Background Definitive chemoradiation is the primary treatment for locally advanced head and neck carcinoma (LAHNSCC). Optimising outcome predictions requires validated biomarkers, since TNM8 HPV could have limitations. Radiomics may enhance risk stratification. Methods This single-centre observational study collected clinical data baseline CT scans from 171 LAHNSCC patients treated with chemoradiation. The dataset was divided into training (80%) test (20%) sets, a 5-fold...