A5009064259- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Sulfur Compounds in Biology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Genetic factors in colorectal cancer
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Yeasts and Rust Fungi Studies
- Vitamin C and Antioxidants Research
- Gout, Hyperuricemia, Uric Acid
- Redox biology and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Aldose Reductase and Taurine
- Prenatal Substance Exposure Effects
INCLIVA Health Research Institute
2014-2023
Universitat de València
2001-2021
Menéndez Pelayo International University
2020
Hospital Clínico Universitario de Valencia
2004-2017
Centro de Investigación Biomédica en Red
2017
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2008-2011
Sistemas Genómicos
2008
Universidad de Navarra
2005
Département Biologie et Amélioration des Plantes
1995
Obesity has grown worldwide over the last few decades. In its different degrees, obesity is accompanied by many clinical and biochemical alterations reflecting pathological condition of various body tissues. Among mechanisms underlying pathogenesis associated complications, oxidative stress (OS) may be playing an important role. present study, we have characterized at systemic level degree OS status in a group morbid obese patients (BMI>40 kg/m2) basal sate modulation during one year after...
This study examines the activity of antioxidant N ‐acetylcysteine on bleomycin‐induced pulmonary fibrosis in rats with emphasis early inflammatory phase. Rats receiving (300 mg kg −1 day , intraperitoneal) had less augmented lung wet weight, and lower levels proteins, lactate dehydrogenase, neutrophil macrophage counts bronchoalveolar lavage fluid myeloperoxidase a betterment histological score at 3 days postbleomycin. A diminished GSH/GSSG ratio lipid hydroperoxides were observed These...
Oxidative stress is involved in the pathophysiology of inflammatory airway diseases including asthma; therefore, antioxidants might be clinical benefit asthma treatment. In present study, effects N ‐acetylcysteine on sensitised brown Norway rats were examined. ‐Acetylcysteine (3 mmol·kg body weight −1 administered orally) was given daily for 1 week before challenge and various antigen-induced pulmonary responses studied. Antigen exposure increased lipid peroxidation bronchoalveolar lavage...
Untreated hypertensive patients show increased oxidative stress and decreased antioxidant enzyme activity in mononuclear cells. Therefore, the objective of this study was to determine whether or not low observed cells subjects is part dependent on a defective mechanisms. Activity mRNA level enzymes, CuZn- Mn-superoxide dismutases, catalase, glutathione peroxidase type 1, reductase were simultaneously measured controls (n = 38) 35), absence during antihypertensive treatment. An increase...
Abstract Introduction Molecular-matched therapies have revolutionized cancer treatment. We evaluated the improvement in clinical outcomes of applying an in-house customized Next Generation Sequencing panel a single institution. Methods Patients with advanced solid tumors were molecularly selected to receive molecular-matched treatment into early phase trials versus best investigators choice, according evaluation multidisciplinary molecular tumor board. The primary endpoint was...
Background The role of genetic variations within the ghrelin gene on cardiometabolic profile and nutritional status is still not clear in humans, particularly elderly people. Objectives We investigated six SNPs their relationship with metabolic syndrome (MS) components. Subjects Methods 824 subjects (413 men/411 women, age 77.31±5.04) participating Mataró aging study (n = 310) Hortega 514) were analyzed. Anthropometric variables, ghrelin, lipids, glucose blood pressure levels measured,...
Objectives Oxidative stress can modulate blood pressure levels in different models. Xanthine oxidoreductase is one of the enzymes producing free radicals cardiovascular system, and it contribute to increment oxidative and, consequently, pressure. We analyzed association between −337GA 565+64CT polymorphisms xanthine gene with levels. Methods These were studied a case–control study (185 patients hypertension 385 normotensive controls), we found that these related This was high showed an...
Context: Autosomal dominant hypercholesterolemia (ADH) is a genetic disorder characterized by increased low-density lipoprotein (LDL)-cholesterol levels, leading to high risk of premature cardiovascular disease. More than 900 mutations in LDL receptor, six APOB and 10 PCSK9 have been identified as cause the disease different populations. All known causing produce an increase enzymatic activity this protease. Up now, there are data about implication ADH low number populations, not including...
The objective of the study was to evaluate oxidative stress (OS) status in subjects with different cardiovascular risk factors. With this mind, we have studied three models high risk: hypertension (HT) and without metabolic syndrome, familial hypercholesterolemia (FH) combined hyperlipidemia (FCH) insulin resistance. Oxidative markers (oxidized/reduced glutathione ratio, 8-oxo-deoxyguanosine malondialdehide) together activity antioxidant enzyme triad (superoxide dismutase, catalase,...
We used restriction fragment length polymorphisms to examine mitochondrial genome rearrangements in 36 wild strains of the cultivated basidiomycete Agrocybe aegerita, collected from widely distributed locations Europe. identified two polymorphic regions within DNA which varied independently: one carrying Cox II coding sequence and other I, ATP6, ATP8 sequences. Two types mutations were responsible for that we observed and, accordingly, involved A. aegerita evolution: (i) point mutations,...
Background/Objectives Obesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system related endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (EDNRA) activates lipolysis adipocytes, the two endothelin receptors mediate arsenic-stimulated adipocyte dysfunction, regulate adiposity by modulating adiponectin activity different situations and, therefore, influence obesity development. The aim...
Hypertension is frequently associated with oxidative stress caused by high production of reactive oxygen species and compromised antioxidant defenses. Humans essential hypertension, or without treatment, controls were examined (35 hypertensive 30 normotensive). We noted a discordant response the glutathione thioredoxin systems in hypertension to antihypertensive treatment. Further studies examining significance these thiols outcomes are warranted.
Familial hypercholesterolemia (FH) is a frequent form of autosomal-dominant that predisposes to premature coronary atherosclerosis. FH caused by sequence variations in the gene coding for LDL receptor (LDLR). This has wide spectrum variations, and genetic diagnosis can be performed 2 strategies.Point large rearrangements were screened along all LDLR (promoter, exons, flanking intron sequences).We sample 129 probands from Valencian Community, Spain, identified 54 different variations. The...
The specific characteristics of copy number variations (CNVs) require methods detection and characterization. We developed the Easy One-Step Amplification Labeling procedure for CNV (EOSAL-CNV), a new method based on proportional amplification labeling amplicons in 1 PCR.We used tailed primers pair probes (only labeled) all just reaction. Products were loaded directly onto capillary DNA sequencer fragment sizing quantification. Data obtained could be analyzed by Microsoft Excel spreadsheet...
Methods presently employed for detection of large rearrangements have several drawbacks, such as the amount sample and time required, technical difficulty, or probability false-negative carriers. Using low-density-lipoprotein receptor (LDLR) gene, whose mutations are responsible familial hypercholesterolemia (FH), we developed a procedure to detect in this gene based on semiquantitative PCR, with important improvements compared previous methods. Our method covers complete LDLR introduces an...
Macronutrients represent risk factors for hyperlipidemia or diabetes. Lipid alterations and type 2 diabetes mellitus are global health problems. Overexpression of sterol regulatory element-binding factor (Srebf2) in transgenic animals is linked to elevated cholesterol levels development. We investigated the impact increased Srebf2 locus expression effects control high-fat, high-sucrose (HFHS) diets on body weight, glucose lipid metabolisms mice (S-mice). Wild (WT) S-mice were fed with both...