A5109979382- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Diabetes Management and Research
- Vasculitis and related conditions
- Retinal and Optic Conditions
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Knowledge Societies in the 21st Century
- Otitis Media and Relapsing Polychondritis
- Uterine Myomas and Treatments
- Ethics and bioethics in healthcare
- Biochemical Analysis and Sensing Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Endometriosis Research and Treatment
- Plant and soil sciences
- Chronic Kidney Disease and Diabetes
- Ocular Infections and Treatments
- Asthma and respiratory diseases
- Adrenal Hormones and Disorders
- Educational Research and Science Teaching
- Sarcoidosis and Beryllium Toxicity Research
- Magnesium in Health and Disease
University of Pamplona
2025
University of Chile
2006-2025
Temuco Catholic University
2024
Hospital Clínico Universitario de Valladolid
2015-2020
Universidad de Valladolid
2015-2020
University of Health Sciences and Pharmacy
2020
Hospital Clínico de la Universidad de Chile
2010-2018
Autoliv (Sweden)
2017
Ministerio de Salud Pública y Asistencia Social
2017
United States Congress
2017
Abstract Background Nirsevimab for infant RSV prevention was introduced in some Northern Hemisphere countries during 2023. Chile first to implement a universal countrywide immunization strategy following cost-effectiveness projections the Southern Hemisphere. This included all newborns born after April 1st, 2024, and infants October We report national-level impact results of this up midwinter period. Methods Lower respiratory tract infections (LRTIs) attributed RSV, causing intensive care...
Purpose: To prospectively compare 2 immunosupressive regimens in patients with active Vogt-Koyanagi-Harada disease spite of systemic glucocorticoid treatment.Methods: Forty-four were diagnosed between 1998 and 2005. Twenty-one developed chronic intraocular inflammation treatment randomized to receive either prednisone azathioprine (AZA) (n = 12) or cyclosporine (CyA) 9).Results: In the AZA group Tyndall score decreased from 1.21 ± 1.10 0.29 0.62 (p < .01), visual acuity (LogMAR) improved...
Hypoparathyroidism is usually controlled with calcium and vitamin-D supplements; in very few cases this treatment fails teriparatide may be an alternative. We report the first case of hypoparathyroidism refractory to therapy requiring multipulse treatment.A 53 year-old woman presented severe hypocalcemia hypomagnesemia after thyroidectomy. Preoperatively, mild hypercalciuria was detected parathyroid hormone (PTH) 69 pg/ml (normal 10-45) 25-OH-vitamin D 9 ng/ml 20-40) normal levels magnesium....
Tachiramantis is a recently proposed genus that includes seven species, four considered threatened with declining trend, while three lack sufficient data for conservation assessment. The Guacharaquita frog lentiginosus one of these substantial information gaps regarding its natural history, threats, and population density changes, particularly in isolated populations such as studied here. In San Antonio, the only location Colombia where T. found, we evaluated changes vegetation cover over 10...
Tachiramantis is a recently proposed genus that includes seven species, four considered threatened with declining trend, while three lack sufficient data for conservation assessment. The Guacharaquita frog lentiginosus one of these substantial information gaps regarding its natural history, threats, and population density changes, particularly in isolated populations such as studied here. In San Antonio, the only location Colombia where T. found, we evaluated changes vegetation cover over 10...
To discover whether tamoxifen is able to extend the survival of patients with advanced hepatocellular carcinoma, we included 80 cirrhosis and carcinoma in a multicenter, double-blind, placebo-controlled trial order analyze influence treatment on survival. The were randomized receive tamoxifen, 40 mg/day (group 1), or placebo 2). Both groups similar age, sex, etiology cirrhosis, biochemical, hematologic hormonal parameters, morphology tumor (nodular vs multinodular massive), Child-Pugh's...
Background The role of genetic variations within the ghrelin gene on cardiometabolic profile and nutritional status is still not clear in humans, particularly elderly people. Objectives We investigated six SNPs their relationship with metabolic syndrome (MS) components. Subjects Methods 824 subjects (413 men/411 women, age 77.31±5.04) participating Mataró aging study (n = 310) Hortega 514) were analyzed. Anthropometric variables, ghrelin, lipids, glucose blood pressure levels measured,...
In this work we evaluated the efficacy and safety of a bread formulation containing chitosan in dyslipidemic type 2 diabetic subjects. For purpose total 18 patients were allowed to incorporate their habitual diets 120 g/day 2% (wt/wt) (chitosan group, n= 9) or standard (control 9). Before study after 12 weeks on modified diet, following parameters evaluated: body weight, plasma cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density (LDL)-cholesterol, triglyceride, hemoglobin...
Purpose: To evaluate the role of azathioprine as an immunosuppressive for steroid-resistant autoimmune uveitis (AIU). Methods: Patients using oral prednisolone active AIU without clinical response were recruited. A standard protocol and was used. Results: Twenty-seven patients participated in study: 3 with anterior uveitis, 1 pars planitis, 4 idiopatic panuveitis, 8 Vogt-Koyonagi-Harada syndrome, Behcet disease, choroidoretinopathies. Complete observed 92%. Eleven had well-tolerated minor...
Heparin-induced thrombocytopenia (HIT) type II is a serious complication of heparin therapy. It presents initially as thrombocytopenia, and associated with thrombosis in 20–50% the cases. HIT related to presence heparin-induced antibodies (HIA), which show specificity for PF4-heparin (PF4-H) complex. The FcγRIIa receptor has been suggested participate pathogenic mechanism HIA. Since patients undergoing chronic hemodialysis (HD) are exposed repeatedly heparin, we studied prevalence HIA their...
Abstract Background The endogenous cannabinoid system plays a role in metabolic aspects of body weight and feeding behaviour. A polymorphism (1359 G/A) (rs1049353) the CB 1 gene was reported as common Caucasian population. present study aimed to investigate association (G1359A) receptor on macronutrient intake females with obesity. Methods sample 896 analysed. bioimpedance measurement, blood pressure serial assessment nutritional 3 days written food records, biochemical analysis were all...
Retrospective review of 44 Chilean patients with Behçet diseaseBackground: Behçet's disease (BD) is a rare multisystemic inflammatory that potentially disabling and may cause death.Aim: To describe the characteristics BD from two centers.Patients method: clinical records attended in rheumatology services between 1985 2007.The "Behçet's Disease Research Committee Japan" (BDCJ) "International Study Group for Disease" (ISG) diagnostic criteria were applied.Results: We found cases (25 males),...
Antecedentes: La histerectomía es una intervención quirúrgica frecuente y de alto costo.Después la operación cesárea, el segundo procedimiento quirúrgico más en ginecología.Objetivos: Evaluar relación costo/efectividad vaginal versus abdominal.Método: Estudio retrospectivo observacional, 2.338 pacientes sometidas a por patología benigna
Effectiveness of infliximab in patients with Behçet syndrome and severe uveoretinitis. Report five casesThe efficacy safety repeated administration was evaluated (two men, three women) accompanied by uveoretinitis.Ocular extra ocular inflammation suppressed all during the observation period without any serious adverse reactions.The results these suggests that TNF-α blockade is effective (Rev Méd Chile 2006; 134: 875-82).
OBJECTIVE—To describe the diagnosis of a patient with neonatal diabetes who had been misdiagnosed type 1 and referred to our hospital for pancreas kidney transplantation because end-stage renal disease. RESEARCH DESIGN AND METHODS—A was made after molecular genetic study revealed mutation in exon 34 ABCC8 gene. Pancreas ill-advised. RESULTS—The switched from insulin glibenclamide 4 months transplantation, confirming that would not have good decision. CONCLUSIONS—This is first report...
Las universidades publicas colombianas tienen una forma muy particular de estimular la produccion intelectual: otorgando a los profesores puntos salariales por sus publicaciones cientificas. Estando tan arraigada cultura corrupcion en el pais, este sistema fue abusado muchas instituciones que otorgaban mediocres, ya no existian criterios objetivos como otorgar estos puntajes, quedando libertad cada universidad realizar esta tarea. [...]
Role of Azathioprine in steroid resistant non infectious ocular inflammatory diseasesBackground: Topical and systemic steroids are the first line treatment disease.Immunosuppresants reserved as a second treatment.Aim: To evaluate role (AZA) coadyuvant immunosuppressive for diseases (OIDs) to therapy retrospective, noncomparative interventional case series.Patients methods: Patients using oral Prednisone due an active or recurrent OID, without clinical response, not receiving any other were...
Aortitis. Report of three casesAortitis is a nonspecific term that describes an inflammation the aortic wall caused by inflammatory, infectious, paraneoplastic and idiopathic diseases.The symptoms are variable nonspecific; therefore high level clinical suspicion required to diagnose it.It often incidental finding while looking for other diagnoses it confirmed mainly through imaging studies.We report cases aortitis: A 29-year-old woman presenting with alopecia, oral nasal ulcers positive...