A5052752775- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Clostridium difficile and Clostridium perfringens research
- Mediterranean and Iberian flora and fauna
- Probiotics and Fermented Foods
- Methane Hydrates and Related Phenomena
- Bacteriophages and microbial interactions
- Botany and Plant Ecology Studies
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Biological Control of Invasive Species
- Liver Disease Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Helicobacter pylori-related gastroenterology studies
- Viral gastroenteritis research and epidemiology
- Protist diversity and phylogeny
- Oral microbiology and periodontitis research
- Environmental DNA in Biodiversity Studies
- Tuberculosis Research and Epidemiology
- Legionella and Acanthamoeba research
- Cancer Immunotherapy and Biomarkers
- Dietary Effects on Health
- Salivary Gland Disorders and Functions
- Metal Extraction and Bioleaching
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015-2025
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2016-2025
Instituto de Salud Carlos III
2023-2025
Centro de Investigación Biomédica en Red
2009-2023
Universitat de València
2010-2021
Institute for Integrative Systems Biology
2018-2021
Regione Campania
2012-2019
Regione Lazio
2017-2019
Consejo Superior de Investigaciones Científicas
2018
Parc Científic de la Universitat de València
2013-2015
The bacterial and archaeal assemblages at two offshore sites located in polar (Greenland Sea; depth: 50 2000 m) Mediterranean (Ionian depth 3000 waters were studied by PCR amplification sequencing of the last 450-500 bp 16S rRNA gene. A total 1621 sequences, together with alignable gene fragments from Sargasso Sea metagenome database, analysed to ascertain variations associated geographical location depth. Ionian m sample appeared be most diverse also had remarkable differences terms...
Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks endurance exercise, without changing diet, affected metagenome and systemic metabolites of overweight women. Previously sedentary women (n = 19) underwent a intervention, but two were excluded due to antibiotic therapy. The microbiota composition functions analyzed by 16S rRNA gene amplicon sequencing metagenomics. Body was with DXA X-ray densitometer serum metabolomics NMR metabolomics. Total...
Abstract Background Sequencing variable regions of the 16S rRNA gene (≃300 bp) with Illumina technology is commonly used to study composition human microbiota. Unfortunately, short reads are unable differentiate between highly similar species. Considering that species from same genus can be associated health or disease it important identify them at lowest possible taxonomic rank. Third-generation sequencing platforms such as PacBio SMRT, increase read lengths allowing sequence whole maximum...
Deep hypersaline anoxic basins in the Mediterranean Sea are a legacy of dissolution ancient subterranean salt deposits from Miocene period. Our study revealed that these not biogeochemical dead ends, but support situ sulfate reduction, methanogenesis, and heterotrophic activity. A wide diversity prokaryotes was observed, including new, abundant, deeply branching order within Euryarchaeota . Furthermore, we demonstrated presence unique, metabolically active microbial community Discovery...
The biosphere of planet Earth is delineated by physico-chemical conditions that are too harsh for, or inconsistent with, life processes and maintenance the structure function biomolecules. To define window on (and perhaps gain insights into limits could tolerate elsewhere), hence understand some most unusual biological activities operate at such extremes, it necessary to causes cellular basis systems failure beyond these windows. Because water plays a central role in biomolecules...
Summary Hydrocarbon‐contaminated superficial sediments collected from the Harbor of Milazzo (Tirrenean Sea, northern Sicily), a zone strongly affected by anthropogenic activities, were examined for in situ biodegradative capacities. A culture‐independent molecular phylogenetic approach was used to study influence hydrocarbon and nutrient addition on activity diversity indigenous microbiota during microcosm evaluation. The autochthonous microbial community non‐polluted represented eubacterial...
Legionella pneumophila subsp. is a gram-negative gamma-Proteobacterium and the causative agent of Legionnaires' disease, form epidemic pneumonia. It has water-related life cycle. In industrialized cities L. commonly encountered in refrigeration towers water pipes. Infection always via infected aerosols to humans. Although many efforts have been made eradicate from buildings, it still contaminates systems. The town Alcoy (Valencian Region, Spain) had recurrent outbreaks since 1999. strain...
The initiation of the intracellular symbiosis that would give rise to mitochondria and eukaryotes was a major event in history life on earth. Hypotheses explain eukaryogenesis fall into two broad competing categories: those proposing host phagocytotic proto-eukaryote preyed upon free-living mitochondrial ancestor (hereafter FMA), an archaebacterium engaged syntrophy with FMA. Of key importance these hypotheses are whether FMA motile or nonmotile, atmospheric conditions under which thrived....
Coeliac disease (CD) is associated with alterations of the intestinal microbiota. Although several Bifidobacterium strains showed anti-inflammatory activity and prevention toxic gliadin peptides generation in vitro, few data are available on their efficacy when administered to CD subjects. This study evaluated effect administration for three months a food supplement based two breve (B632 BR03) restore gut microbial balance coeliac children gluten free diet (GFD). Microbial DNA was extracted...
Biological invasions have become one of the main drivers habitat degradation and a leading cause biodiversity loss in island ecosystems worldwide. The spread invasive species poses particular environmental threat on islands Mediterranean Basin, which are hot spots contain rare habitats endemic species, especially small islands, highly vulnerable to loss. Following recent survey, this paper we aim provide an overview present-day non-native vascular flora based sample 37 located middle Sea,...
Urania basin in the deep Mediterranean Sea houses a lake that is >100 m deep, devoid of oxygen, 6 times more saline than seawater, and has very high levels methane particularly sulfide (up to 16 mM), making it among most sulfidic water bodies on Earth. Along depth profile there are 2 chemoclines, steep one with overlying oxic another between anoxic brines different density, where gradients salinity, electron donors acceptors occur. To identify differentiate microbes processes contributing...
The human gut microbiota is considered one of the most fascinating reservoirs microbial diversity hosting between 400 to 1000 bacterial species distributed among nine phyla with Firmicutes, Bacteroidetes and Actinobacteria representing around diversity. One intriguing issues relates understanding which groups are active players in maintenance homeostasis. Here, we describe fractions compared whole community from raw fecal samples. We studied four healthy volunteers by 16S rDNA gene...
Coffee is one of the most consumed beverages around world, and as a consequence, spent coffee grounds are massively produced residue that causing environmental problems. Reusing them major focus interest presently. We extracted mannooligosaccharides (MOS) from submitted to an in vitro fermentation with human feces. Results obtained suggest MOS able exert prebiotic effect on gut microbiota by stimulating growth some beneficial genera, such Barnesiella, Odoribacter, Coprococcus,...
Evidence suggests that microbiota may contribute to the pathogenesis of several diseases, including cancer. In case bladder cancer, preliminary studies have found alterations in urinary patients with urothelial carcinoma compared healthy individuals. Conversely, differ between men and women, it has been hypothesized these differences are associated lower incidence cancers women. The objective this study was characterize paired samples tumor non-tumor mucosa malignant neoplasia using...
For preliminary screening of human impact on Antarctic coasts, the compositions microbial communities were analyzed in seawater at two sites located Terra Nova Bay Antarctica (Ross Sea) by a combination 16S rRNA gene sequencing and culture techniques. The bacterial community sample from Rod site, proximity to Italian Station, was characterized high abundance sequences belonging microflora typically found soil freshwater environments. In contrast, Adelie Cove station, pristine reference...
Summary An ecological study on distribution of Antarctic bacterial communities was determined by 16S‐based phylogenetic analyses clone libraries derived from RNA and DNA extracted two different marine areas compared between each other. Superficial seawater samples were collected four stations in Ross Sea, three them located Rod Bay one Evans Cove; for station (16S rDNA 16S rRNA) prepared evident divergences site obtained. Of all phylotypes 93.6% found libraries; contrast, only 31 (70.5%)...
Abstract Meso- and bathypelagic ecosystems represent the most common marine ecological niche on Earth contain complex communities of microorganisms that are for part ecophysiologically poorly characterized. Gradients physico-chemical factors (for example, depth-related gradients light, temperature, salinity, nutrients pressure) constitute major forces shaping at activity ‘hot spots’ ocean floor, such as hydrothermal vents, cold seepages mud volcanoes hypersaline lakes, though relationships...