A5050495737- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Nanomaterials for catalytic reactions
- Zeolite Catalysis and Synthesis
- Mesoporous Materials and Catalysis
- Polyoxometalates: Synthesis and Applications
- Chemical Synthesis and Reactions
- Catalysis and Hydrodesulfurization Studies
- Dendrimers and Hyperbranched Polymers
- Covalent Organic Framework Applications
- FOXO transcription factor regulation
- Advanced Photocatalysis Techniques
- DNA Repair Mechanisms
- Catalysis for Biomass Conversion
- Electrocatalysts for Energy Conversion
- Chemical Synthesis and Analysis
- Layered Double Hydroxides Synthesis and Applications
- Mitochondrial Function and Pathology
- Oxidative Organic Chemistry Reactions
- Redox biology and oxidative stress
- Ubiquitin and proteasome pathways
- Carbon dioxide utilization in catalysis
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
Kunsan National University
2015-2024
Stanford University
2010-2022
Panorama Research (United States)
2021-2022
Gynecologic Oncology Group
2021
Institute of Molecular Medicine
2021
Tongmyong University
2017
Taipei Medical University
2015
City Of Hope National Medical Center
2015
SK Group (South Korea)
2006-2012
Korea University
2002-2012
Estrogen receptors (ERs) play key roles in breast cancer development and influence treatment outcome patients. Identification of molecules that regulate ER function may facilitate strategies. The forkhead box class O (FOXO) transcription factor FOXO3a has been suggested to as a tumor suppressor cancer. Using protein-protein interaction screening, we found interacted with ER-alpha ER-beta proteins the human carcinoma cell line MCF-7, suggesting there exists crosstalk between signaling...
BackgroundHumans are exposed to low-dose bisphenol A (BPA) through plastic consumer products and dental sealants containing BPA. Although a number of studies have investigated the mammary gland effects after high-dose BPA exposure, study findings differ. Furthermore, there has been lack mechanistic studies.ObjectiveThe objective this was investigate effect mechanism in cells.MethodsWe evaluated DNA damage following exposure using comet assay immunofluorescence staining, used cell counting...
Abstract This study presents a method for the fabrication of solvent‐resistant poly(dimethylsiloxane) (PDMS) microfluidic devices by coating channel with hybrid inorganic/organic polymer (HR4). modification dramatically increases resistance PDMS channels to various solvents, because it leads significant reduction in rate solvent absorption and consequent swelling. The compatibility modified wide range solvents is investigated evaluating swelling ratio measured through weight changes standard...
A highly porous and stable acid–base bifunctional metal–organic framework, MIL-101–NH2–SO3H, was prepared by direct solvothermal synthesis using two mixed (–NO2, –SO3H) terephthalate linkers followed post-synthesis reduction to the NH2 form, which showed excellent performance for a one-pot tandem deacetalization–nitroaldol reaction.
Background Stimulating antitumor immunity by blocking programmed death-1 (PD-1) or its ligand (programmed death-ligand 1 (PD-L1) is a promising therapy. However, numerous patients respond poorly to PD-1/PD-L1 blockade. Unresponsiveness immune-checkpoint blockade (ICB) can cast significant challenges the therapeutic options for with hard-to-treat tumors. There an unmet clinical need establish new approaches mitigating ICB unresponsiveness in patients. In this study, we investigated efficacy...
The p53 protein arrests the cell cycle at G1 phase when stabilized by interaction between ribosomal proteins and HDM2 under growth-inhibitory conditions. Meanwhile, p53, translocated to mitochondria in response death signals, induces apoptosis via transcription-independent mechanisms. In this report, we demonstrate that mitochondrial L41 (MRPL41) enhances stability contributes p53-induced conditions such as actinomycin D treatment serum starvation. An analysis of MRPL41 expression paired...
We present a simple one-pot synthetic approach for the preparation of monodisperse thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) microcapsules in microfluidic system. Based on mechanism shear force-driven break-off, aqueous droplets monomer solution are continuously generated an immiscible continuous phase containing photoinitiators. Under UV irradiation, activated initiators diffused into interface between and droplets, which trigger polymerization NIPAM monomers. The PNIPAM...
We present a simple synthetic approach for the preparation of cell attachable Janus polyurethane (PU) microfibers in microfluidic system. The synthesis was performed by using laminar flows multiple streams with spontaneous formation carbon dioxide bubbles resulting an asymmetrically porous PU microfiber. fabricated asymmetric microfiber (Janus microfiber) provides two distinctive properties: one is region to promote cellular adhesion and other nonporous rendering mechanical strength...
The direct synthesis of hydrogen peroxide (DSHP) from H2 and O2 is conceptually the most ideal straightforward reaction for producing H2O2 in industry. However, precisely tailored catalysts are still progress large scale production. Here, we report highly efficient industrially relevant prepared by immobilization Pd nanocatalysts onto a functionalized resin. continuous production 8.9 wt % high productivity (180 g (g Pd)−1 h–1) achieved under intrinsically safe less-corrosive conditions...
The DNA damage response (DDR) is a complex signaling network that leads to repair while modulating numerous cellular processes. double-strand breaks (DSBs), highly cytotoxic lesion, activate this system most vigorously. DSB orchestrated by the ATM protein kinase, which phosphorylates key players in its various branches. Proteasome-mediated degradation plays an important role proteome dynamics following induction. Here, we identify nuclear proteasome activator PA28γ (REGγ; PSME3) as novel DDR...