A5087039695- FOXO transcription factor regulation
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Bone health and treatments
- Ubiquitin and proteasome pathways
- PARP inhibition in cancer therapy
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
- Signaling Pathways in Disease
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Bone Metabolism and Diseases
- Protein Kinase Regulation and GTPase Signaling
Stanford University
1991-2023
Panorama Research (United States)
2021-2023
Gynecologic Oncology Group
2021
Institute of Molecular Medicine
2021
City Of Hope National Medical Center
1999-2015
Taipei Medical University
2015
The University of Texas MD Anderson Cancer Center
2000-2008
The University of Texas Health Science Center at Houston
2006
University of Houston
2004
John S. Dunn Foundation
2003
Overexpression of HER-2/neu correlates with poor survival breast and ovarian cancer patients induces resistance to tumor necrosis factor (TNF), which causes cells escape from host immune defenses. The mechanism HER-2/neu-induced TNF is unknown. Here we report that activates Akt NF-kappaB without extracellular stimulation. Blocking the pathway by a dominant-negative sensitizes HER-2/neu-overexpressing TNF-induced apoptosis inhibits IkappaB kinases, phosphorylation, activation. Our results...
Arginine methylation has been implicated in the regulation of gene expression. The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds p160 family steroid receptor coactivators (SRCs). This association enhances transcriptional activation by nuclear receptors. Here, we show that embryos with a targeted disruption CARM1 are small size and die perinatally. two known substrates, poly(A)-binding protein (PABP1) cofactor p300, was abolished knockout cells. However,...
Transforming growth factor β (TGF-β)-activated kinase (TAK1) is known for its involvement in TGF-β signaling and ability to activate the p38-mitogen-activated protein (MAPK) pathway. This report shows that TAK1 also a strong activator of c-Jun N-terminal (JNK). Both wild-type constitutively active mutant stimulated JNK transient transfection assays. Mitogen-activated 4 (MKK4)/stress-activated kinase/extracellular signal-regulated (SEK1), dual-specificity phosphorylates activates JNK,...
Abstract Bone is the most common site of metastases from prostate cancer. The mechanism by which cancer cells metastasize to bone not fully understood, but interactions between and are thought initiate colonization metastatic at that site. Here, we show cadherin-11 (also known as osteoblast-cadherin) was highly expressed in cell line derived had strong homophilic binding recombinant vitro. Down-regulation metastasis–derived PC3 with cadherin-11–specific short hairpin RNA (PC3-shCad-11)...
Diabetic nephropathy (DN) is characterized by mesangial cell (MC) expansion and accumulation of extracellular matrix proteins. TGF-beta increased in MC under diabetic conditions DN activates key signaling pathways, including the phosphoinositide-3-kinase/Akt (PI3K/Akt) pathway. FoxO transcription factors play roles survival oxidative stress are negatively regulated Akt-mediated phosphorylation. We tested whether phosphorylation-mediated inactivation FoxO3a can mediate stress. treatment...
Estrogen receptors (ERs) play key roles in breast cancer development and influence treatment outcome patients. Identification of molecules that regulate ER function may facilitate strategies. The forkhead box class O (FOXO) transcription factor FOXO3a has been suggested to as a tumor suppressor cancer. Using protein-protein interaction screening, we found interacted with ER-alpha ER-beta proteins the human carcinoma cell line MCF-7, suggesting there exists crosstalk between signaling...
BackgroundHumans are exposed to low-dose bisphenol A (BPA) through plastic consumer products and dental sealants containing BPA. Although a number of studies have investigated the mammary gland effects after high-dose BPA exposure, study findings differ. Furthermore, there has been lack mechanistic studies.ObjectiveThe objective this was investigate effect mechanism in cells.MethodsWe evaluated DNA damage following exposure using comet assay immunofluorescence staining, used cell counting...
The fibroblast growth factors (FGFs) play key roles in controlling tissue growth, morphogenesis, and repair animals. We have cloned a novel member of the FGF family, designated FGF-18, that is expressed primarily lungs kidneys at lower levels heart, testes, spleen, skeletal muscle, brain. Sequence comparison indicates FGF-18 highly conserved between humans mice most homologous to FGF-8 among family members. has typical signal sequence was glycosylated secreted when it transfected into...
Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing role both repair mammalian cells that promoted us to examine factors radiation-induced apoptosis. Here, we show FOXO3a (FKHRL1) transcriptional activity protein expression level, nuclear translocation Saos2, p53-null osteosarcoma cell...
Background Stimulating antitumor immunity by blocking programmed death-1 (PD-1) or its ligand (programmed death-ligand 1 (PD-L1) is a promising therapy. However, numerous patients respond poorly to PD-1/PD-L1 blockade. Unresponsiveness immune-checkpoint blockade (ICB) can cast significant challenges the therapeutic options for with hard-to-treat tumors. There an unmet clinical need establish new approaches mitigating ICB unresponsiveness in patients. In this study, we investigated efficacy...
The adenovirus E1A protein has been implicated in increasing cellular susceptibility to apoptosis induced by tumor necrosis factor (TNF); however, its mechanism of action is still unknown. Since activation nuclear κB (NF-κB) shown play an anti-apoptotic role TNF-induced apoptosis, we examined apoptotic and NF-κB TNF the transfectants their parental cells. Here, reported that inhibited rendered cells more sensitive apoptosis. We further showed this inhibition was through suppression IκB...
The DNA damage response (DDR) is a complex signaling network that leads to repair while modulating numerous cellular processes. double-strand breaks (DSBs), highly cytotoxic lesion, activate this system most vigorously. DSB orchestrated by the ATM protein kinase, which phosphorylates key players in its various branches. Proteasome-mediated degradation plays an important role proteome dynamics following induction. Here, we identify nuclear proteasome activator PA28γ (REGγ; PSME3) as novel DDR...
Triple-negative breast cancer (TNBC) is the most lethal form of cancer. Lacking effective therapeutic options hinders treatment TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for schizophrenia angina respectively, inhibit Akt-pS473 phosphorylation promote FOXO3 nuclear localization activation in TNBC cells. BPD TFP survival proliferation cells suppress growth tumors, whereas silencing reduces BPD- TFP-mediated suppression While decrease...
The p38 mitogen-activated protein kinases (MAPK) play a crucial role in stress and inflammatory responses are also involved activation of the human immunodeficiency virus gene expression. We have isolated murine cDNA clones encoding p38-δ MAPK, we localized to mouse chromosome 17A3-B 6p21.3. By using Northern <i>in situ</i> hybridization, examined expression adult tissues embryos. was expressed primarily lung, testis, kidney, gut epithelium tissues. Although predominantly developing septum...