A5055931401- Multisensory perception and integration
- Phonetics and Phonology Research
- Hearing Loss and Rehabilitation
- Speech and Audio Processing
- Tactile and Sensory Interactions
- Categorization, perception, and language
- Face Recognition and Perception
- Visual perception and processing mechanisms
- Reading and Literacy Development
- Neuroscience and Music Perception
- Color perception and design
- Neural and Behavioral Psychology Studies
- Hearing Impairment and Communication
- Neurobiology of Language and Bilingualism
- Speech and dialogue systems
- Neural dynamics and brain function
- Public Relations and Crisis Communication
- Epigenetics and DNA Methylation
- Advanced Radiotherapy Techniques
- Subtitles and Audiovisual Media
- Language, Metaphor, and Cognition
- Action Observation and Synchronization
- Speech Recognition and Synthesis
- Linguistic Variation and Morphology
- Communication in Education and Healthcare
Western Sydney University
2015-2024
The University of Sydney
2008-2024
Incheon National University
2016-2023
Samsung (South Korea)
2021
University of California, San Diego
2017-2018
Woolcock Institute of Medical Research
2017-2018
Korea Nazarene University
2018
The University of Texas MD Anderson Cancer Center
2003-2017
Seoul National University Hospital
2017
California State University, Fullerton
2013-2015
Arginine methylation has been implicated in the regulation of gene expression. The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds p160 family steroid receptor coactivators (SRCs). This association enhances transcriptional activation by nuclear receptors. Here, we show that embryos with a targeted disruption CARM1 are small size and die perinatally. two known substrates, poly(A)-binding protein (PABP1) cofactor p300, was abolished knockout cells. However,...
Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis mammals. The mechanisms underlying establishment remain poorly understood, but a number post-translational modifications histones are implicated antagonizing or recruiting de novo complex. In mouse oogenesis, occurs on largely unmethylated genome nondividing cells, making it highly informative model for examining how histone can shape methylome....
Abstract Ataxia-telangiectasia (A-T) is a genetic disorder caused by mutation of the Atm gene, which controls DNA repair, cell cycling, and redox homeostasis. Even though oxidative stress has been implicated in neurological anomalies A-T, effects ATM loss on neural stem (NSC) survival remained elusive. In this study, we investigated NSC proliferation an animal model for A-T neurodegeneration. We found that cultured subventricular zone neurosphere cells from Atm−/− mice show impaired...
It is widely assumed that the fusiform face area (FFA), a brain region specialized for perception, not involved in processing emotional expressions. This assumption based on proposition FFA identification and only processes features are invariant across changes due to head movements, speaking expressing emotions. The present study tested this by examining whether response human varies expressions with functional magnetic resonance imaging decoding analysis techniques (n = 11). A one vs. all...
Oocyte meiotic progression and maternal-to-zygote transition are accompanied by dynamic epigenetic changes. The functional significance of these changes the key regulators involved largely unknown. Here we show that Setdb1, a lysine methyltransferase, controls global level histone H3 9 di-methyl (H3K9me2) mark in growing oocytes. Conditional deletion Setdb1 developing oocytes leads to arrest at germinal vesicle meiosis I stages, resulting substantially fewer mature eggs. Embryos derived from...
Gametogenesis in mammals entails profound re-patterning of the epigenome. In female germline, DNA methylation is acquired late oogenesis from an essentially unmethylated baseline and established largely as a consequence transcription events. Molecular functional studies have shown that imprinted genes become methylated at different times during oocyte growth; however, little known about kinetics gain genome wide reasons for asynchrony loci. Given predominant role transcription, we sought to...
The coactivator-associated arginine methyltransferase, CARM1, is a positive regulator of transcription. Using high density protein arrays, we have previously identified in vitro substrates for CARM1. One these substrates, TARPP (thymocyte cyclic AMP-regulated phosphoprotein), expressed specifically immature thymocytes. Here, demonstrated that arginine-methylated at single residue, Arg650, both and vivo. In addition, recombinant not methylated by extracts from Carm1-/- cells, indicating there...
Abstract Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis and progression to II. Meiotic is controlled by CDK1 activity accompanied dynamic epigenetic changes. Although signalling pathways regulating well defined, functional significance changes remains largely unknown. Here we show that LSD1, a lysine demethylase, regulates histone H3 4 di-methylation (H3K4me2) in mouse essential for meiotic progression. Conditional deletion...
A-T (ataxia telangiectasia) is a genetic disease caused by mutation in the Atm (A-T mutated) gene that leads to neurodegeneration. Despite an increase numbers of studies this area recent years, mechanisms underlying neurodegeneration human are still poorly understood. Previous demonstrated neural stem cells (NSCs) isolated from subventricular zone (SVZ) Atm-/- mouse brains show defective self-renewal and proliferation, which accompanied activation chronic p38 mitogen-activated protein kinase...
Three naming aloud experiments and a lexical decision (LD) experiment used masked priming to index the processing of written Thai vowels tones. allows for manipulation mapping between orthography phonology not possible in other orthographies, example, use consonants, tone markers both horizontal vertical orthographic positions (HOPs VOPs). Experiment 1 showed that changing vowel prime target slowed down but mark did not. an across item-design different number HOPs way tones were specified. 2...
The study investigated the speech adaptations by older adults (OA) with and without age-related hearing loss made to communicate effectively in challenging communicative conditions. Acoustic analyses were carried out on spontaneous produced during a problem-solving task (diapix) talker pairs different listening There 83 talkers of Southern British English. Fifty-seven OAs aged 65–84, 30 normal (OANH), 27 (OAHL) [mean pure tone average (PTA) 0.250–4 kHz: 27.7 dB HL]. Twenty-six younger (YA)...
Infant-directed (ID) speech provides exaggerated auditory and visual prosodic cues. Here we investigated if infants were sensitive to the match between correlates of ID prosody. We presented 8-month-old with two silent line-joined point-light displays faces speaking different sentences, a single vocal-only sentence matched one displays. Infants looked longer than mismatched signal when full-spectrum was presented; vocal signals contained low-pass filtered at 400 Hz. When display separated...