A5008043585- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Cognitive Functions and Memory
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Mental Health Research Topics
- Second Language Acquisition and Learning
- Text Readability and Simplification
- Technology Use by Older Adults
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Memory Processes and Influences
- Health disparities and outcomes
- Geriatric Care and Nursing Homes
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Disease and Adiposity
- S100 Proteins and Annexins
- Vascular Malformations Diagnosis and Treatment
- Reading and Literacy Development
- Heart Rate Variability and Autonomic Control
- Chronic Disease Management Strategies
- Nutritional Studies and Diet
The University of Texas at Austin
2020-2025
Boston University
2014-2021
Brigham and Women's Hospital
2014-2019
Harvard University
2015-2019
Massachusetts General Hospital
2015-2016
Athinoula A. Martinos Center for Biomedical Imaging
2015
Purpose There is a rapid growth of telepractice in both clinical and research settings; however, the literature validating translation traditional methods assessments interventions to valid remote videoconference administrations limited. This especially true field speech-language pathology where language communication can be easily conducted via administration. The aim this study was validate administration Western Aphasia Battery–Revised (WAB-R). Method Twenty adults with chronic aphasia...
Neuropsychologists are developing more challenging and specific tests to detect early subtle changes in cognition related preclinical Alzheimer's disease (AD). The 16-item Face–Name Associative Memory Exam (FNAME-16) is a paired associative memory test able associated with biomarker evidence of AD. However, as individuals progress along the AD trajectory, measures that sensitive at stage may become too by Mild Cognitive Impairment (MCI). Our goal was develop modified version face–name...
People with poststroke aphasia (PWA) are at increased risk for developing symptoms of depression. However, access to mental health (MH) care is often limited this population. The goal study was survey clinicians about current practices and specifically examine (1) whether they work PWA, (2) how observe mood disorders in (3) these treated, (4) who provides treatment (5) what consists of, (6a) training receive (6b) provide their trainees. A 19-question multiple-choice free-response shared...
We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers.
Introduction Bilinguals with aphasia (BWA) present varying degrees of lexical access impairment and recovery across their two languages. Because both languages may benefit from therapy, identifying the optimal target language for treatment is a current challenge research clinical practice. Prior has demonstrated that BiLex computational model can accurately simulate in healthy bilinguals, response bilingual aphasia. Here, we aim to determine whether predict outcomes BWA treated untreated...
Abstract Predicting language therapy outcomes in bilinguals with aphasia (BWA) remains challenging due to the multiple pre- and poststroke factors that determine deficits recovery of their two languages. Computational models simulate impairment treatment BWA can help predict response identify optimal for treatment. Here we used BiLex computational model behavioral profile a retrospective sample 13 Spanish-English who received one Specifically, simulated prestroke naming ability each...
Impairment in instrumental activities of daily living (IADL) may occur the earliest stages mild cognitive impairment (MCI). However, there are few reliable measures IADL MCI or that have a sufficient range scores clinically normal (CN) elderly. The objective this pilot study was to examine convergent validity phone performance-based instrument, Harvard Automated Phone Task (APT), designed measure changes Alzheimer's disease (AD), with other sensitive and subjective everyday functional...
Hypothesis-driven studies have demonstrated that sex moderates many of the relationships between brain health and cardiometabolic disease, which impacts risk for later-life cognitive decline. In present study, we sought to further our understanding associations multiple markers integrity cardiovascular in a midlife sample 266 individuals by using network analysis, technique specifically designed examine complex among systems at once. Separate models were constructed male female participants...
Impairment in activities of daily living (ADL) is a major burden for Alzheimer's disease (AD) dementia patients and caregivers. Multiple subjective scales few performance-based instruments have been validated proven to be reliable measuring instrumental ADL AD but less so amnestic mild cognitive impairment (MCI). Our objective was validate new instrument early AD, which taps the high level tasks that challenge seniors life. One hundred twenty-nine subjects (91 clinically normal elderly (CN),...
The Controlled Oral Word Association Test (COWAT) is a widely utilized measure of phonemic fluency. However, two issues remain: (1) whether demographic, cognitive variables, or version test administered predict performance; (2) if the predictive Mild Cognitive Impairment (MCI). Recent studies report that item-level analyses such as lexical frequency may be more sensitive to early change. purpose this study was examine clinical utility COWAT, considering both total correct words and...
Impairment in instrumental activities of daily living (ADL) has been demonstrated mild cognitive impairment (MCI) and precedes dementia. Most performance-based ADL instruments have targeted mild-moderate AD dementia, but recent focused on MCI. Our objective was to validate a new instrument, the Harvard Automated Phone Task (APT). One hundred eighty eight subjects (45 young normal (YN), 129 clinically (CN) elderly, 14 MCI) participated an investigator-initiated study. All underwent clinical...
Recent reports document sex differences in midlife brain integrity and metabolic health, such that more relationships are detectable between syndrome (MetS) components markers of health females than males. Midlife is characterized by a rapid decrease endogenous estrogen levels for women which thought to increase risk cardiometabolic disease neurocognitive decline. Our study used network models, designed explore the interconnectedness organization among many variables at once, compare...
Age-related declines in memory have been well-documented. However, some individuals reach their 8th -10th decade while maintaining strong performance. We were interested which demographic and biomarker variables distinguished aged 75+ who score the top 20th percentile for (Optimal Agers) from typically scoring peers (Typical Agers). A total of 125 clinically healthy older adults (CDR=0; MMSE: 28.78±1.07) 75-90 Harvard Aging Brain Study underwent annual testing neuroimaging (MRI PET amyloid)...
Purpose: There is a rapid growth of telepractice in both clinical and research settings; however, the literature validating translation traditional methods assessments interventions to valid remote videoconference administrations limited. This especially true field speech-language pathology where language communication can be easily conducted via administration. The aim this study was validate administration Western Aphasia Battery–Revised (WAB-R).Method: Twenty adults with chronic aphasia...
Abstract Background Hispanic/Latino (H/L) older adults are at increased risk for AD, demonstrate an earlier age of dementia onset, and more likely to experience delays in AD diagnosis treatment relative Non‐Hispanic Whites. These racial/ethnic disparities the consequence structural inequities socioeconomic disadvantages (e.g., income, education) that disproportionately affect H/Ls promote pathologic inflammatory cascades. Although low status (SES) inflammation have independently been linked...