A5076272887- Dementia and Cognitive Impairment Research
- Poisoning and overdose treatments
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Liver Disease and Transplantation
- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Plant-based Medicinal Research
- Opioid Use Disorder Treatment
- Prenatal Substance Exposure Effects
- Neonatal Health and Biochemistry
- Mechanical Circulatory Support Devices
- Cardiac electrophysiology and arrhythmias
- Bat Biology and Ecology Studies
- Streptococcal Infections and Treatments
- Musculoskeletal pain and rehabilitation
- Cannabis and Cannabinoid Research
- Education and Critical Thinking Development
- Effects of Environmental Stressors on Livestock
- Viral Infections and Vectors
- Methemoglobinemia and Tumor Lysis Syndrome
- Rabies epidemiology and control
Hennepin Healthcare Research Institute
2024-2025
University of Minnesota
2024-2025
University of Minnesota Medical Center
2024
Hennepin County Medical Center
2024
Denver Health Medical Center
2018-2023
Health and Hospital Corporation
2021-2023
University of Colorado Denver
2018-2023
Washington Poison Center
2023
Massachusetts General Hospital
2012-2015
Harvard University
2012-2015
Objective Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis Alzheimer disease (AD), staging and monitoring progression, development disease‐modifying therapies. Methods We acquired positron emission tomography (PET) using 18 F T807 (AV1451), amyloid‐β PET 11 C Pittsburgh compound B (PiB) in older clinically normal individuals, symptomatic patients with mild cognitive impairment or AD dementia. Results found abnormally high cortical binding...
Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.We sought to determine whether apathy associated with cortical amyloid burden measured by Pittsburgh Compound B (PiB) positron emission tomography (PET) regional hypometabolism 18F-fluorodeoxyglocuse (FDG) PET MCI.We found a significant association between increased (lower Evaluation Scale score) greater PiB retention independent of age (pr s =-0.46, p=0.03), but no FDG...
Venoarterial extracorporeal membrane oxygenation (VA ECMO) may provide temporary hemodynamic support for patients with severe vasodilatory shock due to toxicologic ingestion. In a series of 10 cases children less than 18 years age who received VA ECMO toxicologic-induced shock, there were eight survivors and two nonsurvivors died significant neurologic injury. Upon initiation support, had decline in Vasoactive-Inotrope Scores (VIS). With the exception one survivor VIS range 5–10, seven...
We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers.
Background: Impairment in instrumental activities of daily living (IADL) begins as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. IADL AD dementia has been associated infe
The study characterizes cannabis toxicity in relation to tetrahydrocannabinol (THC) dose pediatric edible ingestions.This is a retrospective review of children aged <6 years presenting with ingestions known THC within hospital network (January 1, 2015-October 25, 2022). Cannabis was characterized as severe if patients exhibited cardiovascular (bradycardia, tachycardia/hypotension requiring vasopressors or intravenous fluids, other dysrhythmias), respiratory (respiratory failure, apnea,...
Sodium nitrite overdose leads to profound methemoglobinemia and may quickly progress death. It is an increasingly common method of suicide often fatal. Methylene blue effective but time-sensitive antidote that has the potential save lives when administered early. In this case report, we describe a fatal sodium subsequent creation prehospital protocol for our large urban Emergency Medical Services system.
Abstract Biofluid proteomics is a sensitive and high throughput technique that provides vast amounts of molecular data for biomarker discovery. More recently, dried blood spots (DBS) have gained traction as stable, noninvasive, relatively cheap source proteomic identification in disease injury. Snake envenomation responsible significant morbidity mortality worldwide; however, much remains unknown about the systemic response to acquiring biological samples analysis major hurdle. In this...
Acetaminophen overdose is common in the pediatric population. N-acetylcysteine (NAC) effective at preventing liver injury most patients when started shortly after overdose. Delays to therapy increase risk of hepatotoxicity and failure that may necessitate organ transplant. Animal studies have demonstrated fomepizole provide added benefit acetaminophen because its ability block metabolic pathway produces toxic metabolite downstream inhibition oxidative stress pathways lead cell death. Several...
Impairment in instrumental activities of daily living (IADL) begins as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. IADL AD dementia has been associated inferior parietal, temporal, and superior occipital hypometabolism using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). The objective this study was investigate the relationship between regional FDG metabolism cross-sectionally longitudinally clinically normal...
To evaluate the association of beta-amyloid burden and APOE status with longitudinal change in FDG metabolism CDR Sum-of-Boxes (SB) cognitively normal (CN) mildly impaired (MCI) subjects. We evaluated CN (baseline CDR=0; n=297) MCI (CDR=0.5; n=227) participants ADNI Harvard Aging Brain study respect to known (CSF 42 or thresholded PiB), APOE-ε4 status, SB data (average ∼2.5 year follow-up). activity was scaled cerebellar-vermis plus pons mapped Freesurfer onto a standardized cortical surface...
Most studies have not demonstrated a clear relationship between regional amyloid burden and specific clinical symptomatology in AD. Although group level analyses typically reveal diffuse elevation across heteromodal cortices high PiB subjects, it remains unclear whether any spatial specificity exists retention during the early stages of deposition. We explored 2 sets data that potentially reflect Group 1 included cognitively normal elderly [CN, n = 116, mean age 74(6)], from Harvard Aging...
Most studies have not demonstrated a clear relationship between regional amyloid burden and specific clinical symptomatology in AD. Although group level analyses typically reveal diffuse elevation across heteromodal cortices high PiB subjects, it remains unclear whether any spatial specificity exists retention during the early stages of deposition. We explored 2 sets data that potentially reflect Group 1 included cognitively normal elderly [CN, N=116, mean age=74(6)], from Harvard Aging...
Through emergency medicine's evolution as a specialty, residency leadership embraced advanced training in educational theory and practice.It is not clear that leaders medical toxicology programs have followed this paradigm.Medical toxicologists long been recognized master educators with range of experience educating fellows, residents, members the public, allied health care providers.However, enthusiasm historic prowess bedside small group teaching may translate to designing running an...