A5018164434- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Trauma Management and Diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Ultrasound in Clinical Applications
- Healthcare Decision-Making and Restraints
- Radiation Dose and Imaging
- Traumatic Brain Injury Research
- Mechanical Circulatory Support Devices
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Advanced NMR Techniques and Applications
- Glycosylation and Glycoproteins Research
- Trauma and Emergency Care Studies
- Opioid Use Disorder Treatment
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Methemoglobinemia and Tumor Lysis Syndrome
Hennepin County Medical Center
2016-2025
Hennepin Healthcare Research Institute
2019-2024
University of Minnesota
2023-2024
University of Minnesota Medical Center
2023-2024
Hennepin County
2016-2024
College of Menominee Nation
2023
Mercy Hospital for Women
2021
Columbia University Irving Medical Center
2019
Orthopaedic Research Foundation
2018
University of Richmond
2017
Glioblastoma (GBM) is a highly malignant brain tumor with dismal prognosis. Gene expression profiling of GBM has revealed clinically relevant subtypes, and this provides exciting opportunities to better understand disease pathogenesis. Results from an increasing number studies demonstrate role for the immune response in cancer progression, yet it unclear how differs across subtypes affects outcome. Utilizing gene data The Cancer Genome Atlas Project Expression Omnibus database, we enrichment...
Fumonisins were monitored in corn grain collected from Bt hybrids grown 107 locations across the United States 2000-2002. contain Cry1Ab protein Bacillus thuringiensis that controls European borers and other stalk-boring pests. Fumonisin levels frequently lower field trials under conditions of natural (FACT trials) or manual insect infestation (university trials). Over three years FACT trials, there 126/210 comparisons when fumonisin control >2 ppm, exceeding U.S. FDA guidance 2 ppm for...
High-grade astrocytomas (HGAs), corresponding to World Health Organization grades III (anaplastic astrocytoma) and IV (glioblastoma; GBM), are biologically aggressive, their molecular classification is increasingly relevant clinical management. PDGFRA amplification common in HGAs, although its prognostic significance remains unclear. Using fluorescence situ hybridization (FISH), the most sensitive technique for detecting copy number gains, we determined status 123 pediatric 263 adult HGAs. A...
Glioblastoma (GBM), a uniformly lethal brain cancer, is characterized by diffuse invasion and abnormal activation of multiple receptor tyrosine kinase (RTK) signaling pathways, presenting major challenge to effective therapy. The many RTK pathways regulated extracellular heparan sulfate proteoglycans (HSPG), suggesting these molecules may be targets in the tumor microenvironment. In this study, we demonstrated that sulfatase, SULF2, an enzyme regulates HSPG-dependent was expressed primary...
Abstract Mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among most prevalent in low-grade glioma and secondary glioblastoma, represent an early pathogenic event, associated with epigenetically driven modulations metabolism. Of particular interest is recently uncovered relationship between IDH1 mutation decreased activity branched-chain amino acid transaminase (BCAT1) enzyme. Noninvasive imaging methods that can assess BCAT1 could therefore improve detection mutant tumors aid...
Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers enzyme with novel ability to convert α-ketoglutarate 2-hydroxyglutarate, ultimately leading tumorigenesis. The major source 2-hydroxyglutarate production is glutamine, which, cancer, also tricarboxylic acid cycle (TCA) anaplerosis. An alternate anaplerosis pyruvate flux via carboxylase (PC), which common pathway normal astrocytes. goal this study was...
Data suggest patients suffering acute coronary occlusion myocardial infarction (OMI) benefit from prompt primary percutaneous intervention (PPCI). Many emergency medical services (EMS) activate catheterization labs to reduce time PPCI, but suffer a high burden of inappropriate activations. Artificial intelligence (AI) algorithms show promise improve electrocardiogram (ECG) interpretation. The objective was evaluate the potential AI false positive activations without missing OMI.
ABSTRACT Background Emergency tracheal intubation is a common and high-risk procedure. Ketamine etomidate are sedative medicines commonly used to induce anesthesia for emergency intubation, but whether the induction medication affects patient outcomes uncertain. Research Question Does use of ketamine decrease incidence death among adults undergoing compared etomidate? Study Design Methods The Randomized trial Sedative choice Intubation (RSI) pragmatic, multicenter, unblinded, parallel-group,...
Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion exons 2-7 EGFR (EGFRvIII) is common alteration in glioblastoma (GBM). While this can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous. To investigate role for tumor phenotype we used neural progenitor cell-based murine model GBM driven by signaling and generated cells with high low activation, pEGFRHi pEGFRLo. In vivo, ex vitro studies suggested direct association between activity increased...
Abstract Background The optimal order of drug administration (sedative first vs. neuromuscular blocking agent first) in rapid sequence intubation ( RSI ) is debated. Objective We sought to determine if was associated with the time elapsed from end a successful attempt. Methods conducted planned secondary analysis randomized trial adult ED patients undergoing emergency orotracheal that demonstrated higher first‐attempt success bougie use compared tracheal tube + stylet. Drug choice, dose, and...
Bag-valve-mask ventilation and endotracheal intubation have been the mainstay of prehospital airway management for over four decades. Recently, supraglottic device use has risen due to various factors. The combination bag-valve-mask ventilation, intubation, devices allows successful in a majority patients. However, there exists small portion patients who are unable be intubated cannot adequately ventilated with either facemask or airway. These require an emergent surgical A is important...
Sodium nitrite overdose leads to profound methemoglobinemia and may quickly progress death. It is an increasingly common method of suicide often fatal. Methylene blue effective but time-sensitive antidote that has the potential save lives when administered early. In this case report, we describe a fatal sodium subsequent creation prehospital protocol for our large urban Emergency Medical Services system.
The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models would greatly accelerate the development novel therapeutic options for chordoma. authors sought to establish and characterize primary xenograft model that faithfully recapitulates molecular features human chordoma.Chordoma tissue from clival tumor was obtained at time surgery implanted subcutaneously into NOD-SCID interleukin-2 receptor gamma (IL-2Rγ) null (NSG) mouse hosts....
Objectives The epidemic of opioid use disorder (OUD) remains pervasive in the United States. In an effort to increase availability and timeliness medications for (MOUD), several agencies States (US) offer buprenorphine by prehospital providers selected patients, though published data limited. We describe preliminary safety feasibility training all paramedics within a single agency administer field without online medical control simultaneously treat withdrawal initiate MOUD.
OBJECTIVES Clinical management of traumatic brain injury (TBI) focuses on preventing secondary from cerebral edema and ongoing anoxic injury. Consensus guidelines recommend maintaining systolic blood pressure (SBP) > 110 mmHg. A recent prehospital study suggested lowest adjusted mortality 130 mmHg to 180 mmHg, suggesting the ideal may be higher. This aims explore externally validate association between out hospital SBP in a nationwide database.