A5030403147- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Diversity and Career in Medicine
- Medical Education and Admissions
- Cardiac Structural Anomalies and Repair
- Metal complexes synthesis and properties
- Emergency and Acute Care Studies
- Cardiovascular and Diving-Related Complications
- Innovations in Medical Education
- Appendicitis Diagnosis and Management
- Electronic Health Records Systems
- Viral gastroenteritis research and epidemiology
- Ethics in Clinical Research
- Fibroblast Growth Factor Research
- Cancer Immunotherapy and Biomarkers
- Hemodynamic Monitoring and Therapy
- Injury Epidemiology and Prevention
- Medical Malpractice and Liability Issues
Vanderbilt University Medical Center
2024-2025
Virginia Commonwealth University
2016-2024
University of Alabama at Birmingham
2018-2021
Rationale: Among mechanically ventilated critically ill adults, the PILOT (Pragmatic Investigation of Optimal Oxygen Targets) trial demonstrated no difference in ventilator-free days among lower, intermediate, and higher oxygen-saturation targets. The effects on long-term cognition related outcomes are unknown.Objectives: To compare lower (90% [range, 88–92%]), intermediate (94% 92–96%]), (98% 96–100%]) targets outcomes.Methods: Twelve months after enrollment trial, blinded...
OBJECTIVES: Withdrawal of life-sustaining therapies for perceived poor neurologic prognosis (WLST-N) is common after resuscitation from cardiac arrest and may bias outcome estimates models trained using observational data. We compared several approaches to prediction with the goal identifying strategies quantify reduce this bias. DESIGN: Retrospective cohort study. SETTING: Two academic medical centers (“UPMC” “University Alabama Birmingham” [UAB]). PATIENTS: Comatose adults resuscitated...
More than 600,000 adults in the United States experience a cardiac arrest each year. After resuscitation from arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcomes after is uncertain. does lower oxygen saturation (SpO 2 ) improve compared to higher SpO target? We conducted secondary analysis of who experienced before enrollment Pragmatic Investigation optimal Oxygen Targets (PILOT) trial. PILOT trial assigned critically ill receiving...
ABSTRACT Background Emergency tracheal intubation is a common and high-risk procedure. Ketamine etomidate are sedative medicines commonly used to induce anesthesia for emergency intubation, but whether the induction medication affects patient outcomes uncertain. Research Question Does use of ketamine decrease incidence death among adults undergoing compared etomidate? Study Design Methods The Randomized trial Sedative choice Intubation (RSI) pragmatic, multicenter, unblinded, parallel-group,...
Away rotations are common among senior medical students preparing to apply for residency. For competitive specialties, multiple away may be viewed as a de facto requirement strong application. Although often valuable learning experiences, variety of noneducational factors motivate enroll, including the need letters recommendation, students' uncertainty regarding their strength applicants, perceived competitiveness residency applications, and conflicting guidance from advisors.Students who...
Background: Disability-adjusted life years (DALY) are a common public health metric used to estimate disease burden. The DALY due pediatric out-of-hospital cardiac arrest (OHCA) in the United States is unknown. We aimed OHCA and compare it with other leading causes of death disability States. Methods: conducted retrospective observational analysis national Cardiac Arrest Registry Enhance Survival database. were calculated as sum lost lived disability. Years using all (age <18 years)...
The use of live animals for surgical training is a well-known, deliberated topic. However, medical students who rate the experience high not only in improving their techniques, but also positively influencing confidence levels operating room later careers. Therefore, we hypothesized that animal models unique and influential component preclinical education.Medical student performed following procedures using mice; orthotopic implantation cancer cells into fat pad subsequently radical...
Background and Purpose— The Graeb score is a visual rating scale of intraventricular hemorrhage (IVH) on noncontrast head CT. Little data exist in the hyperacute (<6 hour) period for reliability predictive value modified Score (mGS) or original (oGS) clinical outcomes their correlation with quantitative IVH volumes. Methods— A retrospective analysis multicenter prospective intracranial study was performed. oGS mGS inter-observer agreement volume baseline CT were calculated by intraclass...
There are conflicting data regarding the accuracy of thoracic point-of-care ultrasound (POCUS) in detecting traumatic pneumothorax (PTX). The purpose our study was to determine POCUS performed by emergency physicians for detection clinically significant PTX blunt and penetrating trauma patients.We conducted a retrospective institutional review board-approved patients 15 years or older presenting urban Level I academic center from December 2021 June 2022. All were imaged with single-view...
Maiga, Amelia W. MD, MPH; DeMasi, Stephanie C. MD; Qian, Edward T. MS; Semler, Matthew MSc; Casey, Jonathan D. MSc Author Information
There are no conflicts of interest for any authors to report this effort.
<h3>Study objective</h3> To examine the association between neuromuscular blocking agent received (succinylcholine versus rocuronium) and incidences of successful intubation on first attempt severe complications during tracheal critically ill adults in an emergency department (ED) or ICU. <h3>Methods</h3> We performed a secondary analysis data from 2 multicenter randomized trials undergoing ED Using generalized linear mixed-effects model with prespecified baseline covariates, we examined...
For critically ill adults receiving invasive mechanical ventilation, the ventilator mode determines how breaths are delivered. Whether choice of affects outcomes for patients is unknown. To compare effects three common modes (volume control, pressure and adaptive control) on death duration ventilation.
Abstract The high affinity of polynuclear platinum compounds (PPCs) for heparan sulfate (HS) is mediated through a “sulfate clamp” and PPC interactions can be conceptualized as “polyarginine” mimics. Strong HS-PPC binding protects the oligosaccharide against loss metalloshielding.1 Metalloshielding will in principle affect HS with relevant enzymes proteins such heparanase growth factors, similar concept to inhibition DNA-protein modification DNA structure conformation.2 PPCs inhibit cleavage...