A5054338861- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Cardiac Arrest and Resuscitation
- Semantic Web and Ontologies
- Various Chemistry Research Topics
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Metabolism and Genetic Disorders
- Potassium and Related Disorders
- Biomedical Text Mining and Ontologies
- Hemodynamic Monitoring and Therapy
- Hormonal Regulation and Hypertension
- Complement system in diseases
- Mechanical Circulatory Support Devices
- Hemoglobinopathies and Related Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Thermoregulation and physiological responses
- Neonatal Health and Biochemistry
- Chronic Kidney Disease and Diabetes
- Biomedical Research and Pathophysiology
Vanderbilt University Medical Center
2024
Aarhus University
2006-2023
University of Pittsburgh
2020
Aalborg University
2000-2020
University of Pittsburgh Medical Center
2018-2019
Aalborg University Hospital
2008-2017
Aarhus University Hospital
2008-2015
Svendborg Sygehus
1983-2012
National Eye Institute
2010
National Institutes of Health
2010
Objective We aimed to investigate the impact of hyponatremia severity on mortality risk and assess any evidence a dose–response relation, utilizing prospectively collected data from population-based registries. Design Cohort study 279 508 first-time acute admissions Departments Internal Medicine in North Central Denmark Regions 2006 2011. Methods used Kaplan–Meier method (1 – survival function) compute 30-day 1-year patients with normonatremia categories increasing severity. Relative risks...
IgA nephropathy (IgAN) is characterized by a variable clinical course and multifaceted pathophysiology. There substantial evidence to suggest that complement activation plays pivotal role in the pathogenesis of disease. Therefore, inhibition using humanized anti-C5 monoclonal antibody eculizumab could be rational treatment. We report here 16-year-old male with vasculitic form IgAN who failed respond aggressive conventional therapy including high-dose steroids, cyclophosphamide plasma...
The demonstration of impaired C regulation in the thrombotic microangiopathy (TMA) atypical hemolytic uremic syndrome (aHUS) resulted successful introduction inhibitor eculizumab into clinical practice. abnormalities account for approximately 50% aHUS cases; however, mutations non-C gene diacylglycerol kinase- ε have been described recently individuals not responsive to eculizumab. We report here a family which proposita presented with but did respond Her mother had previously post–renal...
Acute hyponatremia is a serious condition, which poses major challenges. Of particular importance what determines plasma sodium concentration ([Na(+)]). Edelman introduced an explicit model to describe [Na(+)] in population as = alpha.(exchangeable Na(+) + exchangeable K(+))/(total body water) - beta. Evidence for the clinical utility of individual and acute sparse. We, therefore, investigated how measured could be predicted porcine hyponatremia. Plasma was estimated from vivo-determined...
<i>Background:</i> Wegener’s granulomatosis is a form of systemic vasculitis typically involving the kidneys and upper lower respiratory tract. Treatment employing cyclophosphamide prednisone has improved prognosis, but relapses treatment-induced side effects still cause severe morbidity frequent mortality. There therefore an urgent need to find new treatment modalities that are efficient few effects. Chimeric anti-CD20 (rituximab) may be one such treatment, apparently working in...
Objective To examine the validity of International Classification Diseases , 10th revision (ICD-10) codes for hyponatraemia in nationwide population-based Danish National Registry Patients (DNRP) among inpatients all ages. Design Population-based validation study. Setting All somatic hospitals North and Central Denmark Regions from 2006 through 2011. Participants: ages admitted to hospital (n=819 701 individual patients) during study period. The patient could be included more than once, our...
Understanding acid-base regulation is often reduced to pigeonholing clinical states into categories of disorders based on arterial blood sampling. An earlier ambition quantitatively explain by measuring production and elimination acid has not become standard practice. Seeking back classical physical chemistry we propose that in any compartment, the requirement electroneutrality leads a strong relationship between charged moieties. This derived form general equation stating charge balance,...
The first reported double-blind cross-over comparison between the phosphorus binders calcium carbonate and acetate was undertaken in 15 stable patients on chronic maintenance haemodialysis. Detailed registration of diet analysis protein catabolic rate suggested an unchanged intake during study. It found that predialytic serum phosphate concentration significantly decreased by 0.11 mmol/l (0.34 mg/dl) (P = 0.021, 95% confidence limits 0.02-0.21 mmol/l; 0.06-0.65 treatment. product...
Urinary tract obstruction impairs renal function and is often associated with a urinary acidification defect caused by diminished net H+ secretion and/or HCO3- reabsorption. To identify the molecular mechanisms of these defects, protein expression key acid-base transporters were examined along nephron collecting duct kidneys from rats subjected to 24-h bilateral ureteral (BUO), 4 days after release BUO (BUO-R), or BUO-R experimentally induced metabolic acidosis (BUO-A). Semiquantitative...
Extracorporeal carbon dioxide removal (ECCO 2 R) devices remove CO directly from blood, facilitating ultraprotective ventilation or even providing an alternative to mechanical ventilation. However, ECCO R is not widely available, whereas dialysis available in most intensive care units (ICUs). Prior attempts provide with dialysis, by removing the form of bicarbonate, have been plagued metabolic acidosis. We hypothesized that bicarbonate feasible, provided plasma strong ion difference...
Unilateral ureteral obstruction is a common clinical problem that often associated with urinary acidification defect caused by decreased net H(+) secretion and/or HCO(3)(-) reabsorption. To clarify the molecular mechanisms of these defects we examined expression levels key acid-base transporters along renal nephron segments and collecting duct.Wistar rats (Møllegard Breeding Centre, Eiby, Denmark) underwent 24-hour unilateral obstruction, release followed for 4 days or plus experimental...
Brain edema is suggested to be the principal mechanism underlying symptoms in acute hyponatremia. Identification of mechanisms responsible for global and regional cerebral water homeostasis during hyponatremia is, therefore, utmost importance. To examine osmotic behavior different brain regions muscles, vivo-determined content (WC) was related plasma sodium concentration ([Na + ]) brain/muscle electrolyte content. Acute induced with desmopressin acetate infusion a 2.5% glucose solution...
Objectives: We designed a novel respiratory dialysis system to remove C o 2 from blood in the form of bicarbonate. aimed determine if our removes at rates comparable low-flow extracorporeal removal devices (blood flow < 500 mL/min) large animal model. Design: Experimental study. Setting: Animal research laboratory. Subjects: Female Yorkshire pigs. Interventions: Five bicarbonate experiments were performed. Hypercapnia (P co 90–100 mm Hg) was established mechanically ventilated swine by...