A5067933546- Ion channel regulation and function
- Muscle activation and electromyography studies
- Myasthenia Gravis and Thymoma
- Cardiovascular and exercise physiology
- Pain Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Adenosine and Purinergic Signaling
- Advanced Sensor and Energy Harvesting Materials
- Ion Transport and Channel Regulation
- Neuroscience and Neural Engineering
- Electrolyte and hormonal disorders
- Muscle metabolism and nutrition
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects and Assays
- Cancer Treatment and Pharmacology
- Adipose Tissue and Metabolism
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Antifungal resistance and susceptibility
- Cardiomyopathy and Myosin Studies
- Organic Light-Emitting Diodes Research
- Sports Performance and Training
Aarhus University
2007-2024
Doctors Company (United States)
2024
Senzime (Sweden)
2024
Martini Ziekenhuis
2024
Takeda (United States)
2024
Czech Academy of Sciences, Institute of Physiology
2006
Myasthenia gravis (MG) is a neuromuscular disease that results in compromised transmission of electrical signals at the junction (NMJ) from motor neurons to skeletal muscle fibers. As result, patients with MG have reduced function and present symptoms severe weakness fatigue. ClC-1 specific chloride (Cl − ) ion channel plays important roles regulating fiber excitability during intense exercise. Here, we show partial inhibition an orally bioavailable small molecule (NMD670) can restore rat...
Abstract Aim The skeletal muscle Cl − channels, the ClC‐1 stabilize resting membrane potential and dampen fibre excitability. This study explored whether inhibition can recover nerve‐stimulated force in isolated under conditions of compromised neuromuscular transmission akin to disorders myasthenia gravis Lambert–Eaton syndrome. Methods Nerve‐muscle preparations were from rats. Preparations exposed pre‐or post‐synaptic inhibitors (ω‐agatoxin, elevated extracellular Mg 2+ , α‐bungarotoxin or...
Resting skeletal muscle fibres have a large membrane Cl(-) conductance (G(Cl)) that dampens their excitability. Recently, however, activity was shown to induce PKC-mediated reduction in G(Cl) rat muscles of 40-90%. To examine the physiological significance this for function muscles, study explored effects reductions on contractile endurance isolated muscles. Contractile assessed from ability maintain force during prolonged stimulation under conditions when manipulated by: (i) inhibition PKC,...
Elevated plasma HCO(3)(-) can improve exercise endurance in humans. This effect has been related to attenuation of the work-induced reduction muscle pH, which is suggested performance via at least two mechanisms: 1) less inhibition enzymes and 2) reduced opening K(ATP) channels with ensuing excitability. Aiming determining whether ergogenic effects on muscles, we examined elevating extracellular from 25 40 mM (pH 7.4 7.6) fatigue, intracellular pH (pH(i)), K(+) efflux isolated rat skeletal...
Activity-induced elevation of extracellular purines and pyrimidines has been associated with autocrine paracrine signaling in many tissues. Here we investigate the effect purinergic for excitability contractility depolarized skeletal muscle. Muscle was experimentally depressed by elevating K(+) from 4 to 10 mM, which reduced tetanic force 24 +/- 2% at mM K(+). Upon addition 1 ATP, however, recovered 65 8% control (P < 0.001, n = 5). A similar recovery seen ADP, but not UTP or adenosine. The...
Brain edema is suggested to be the principal mechanism underlying symptoms in acute hyponatremia. Identification of mechanisms responsible for global and regional cerebral water homeostasis during hyponatremia is, therefore, utmost importance. To examine osmotic behavior different brain regions muscles, vivo-determined content (WC) was related plasma sodium concentration ([Na + ]) brain/muscle electrolyte content. Acute induced with desmopressin acetate infusion a 2.5% glucose solution...
During intense exercise, efflux of K(+) from working muscles increases extracellular ([K(+)](o)) to levels that can compromise muscle excitability and hence cause fatigue. In this context, the reduction in exercise-induced elevation [K(+)](o) observed after training humans is suggested contribute increased performance training. Although a similar effect could be obtained by an increase tolerance elevated [K(+)](o), possibility has not been investigated. To examine this, isolated soleus...
Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While facilitates surgical procedures and tracheal intubation, adequate recovery of function after surgery is required support pulmonary function, even mild residual neuromuscular block increases the risk severe postoperative complications. involving can be monitored and, in addition, accelerated by use current antagonists (reversal agents), there a clear clinical need for safe drug...
<title>Abstract</title> Neuromuscular blocking agents (NMBAs) are commonly used to induce skeletal muscle relaxation during surgery. While facilitates surgical procedures and tracheal intubation, adequate recovery of function after surgery is required support pulmonary function, even mild residual neuromuscular block increases the risk severe postoperative complications. involving NMBAs can be monitored and, in addition, accelerated by use current antagonists (reversal agents), there a clear...
In skeletal muscles, contractions elicit a release of ATP into the extracellular space. Extracellular has been recognized as an autocrine and paracrine signaling molecule acting on two purinergic receptor families; metabotrophic P2Y receptors ionotropic P2X receptors. this study we investigate role P2 excitability contractility isolated muscle. Tetanic force production M‐wave amplitude area were investigated in rat soleus muscles incubated Krebs‐Ringer buffer. Exogenously added P2‐receptor...
Increased plasma HCO3- is widely believed to improve exercise endurance in humans. Even though increased has little direct effect on pHi, the ergogenic of thought be related an attenuation depressing lowered pH contractile capacity. Furthermore, it been speculated that better maintenance muscle prevents opening KATP channels, which could reduce work-induced loss fiber K+ and thereby prevent fatigue caused by excitation failure. Based this, we examined increasing buffer concentration from 25...