A5006844551- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Antimicrobial Resistance in Staphylococcus
- Pluripotent Stem Cells Research
- Renal and related cancers
- Neonatal and fetal brain pathology
- Acute Myocardial Infarction Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Renal Diseases and Glomerulopathies
- Trace Elements in Health
- Proteins in Food Systems
- Respiratory viral infections research
- Eosinophilic Disorders and Syndromes
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
- Orthopedic Infections and Treatments
- Renal function and acid-base balance
- Medical Device Sterilization and Disinfection
- Probiotics and Fermented Foods
- Respiratory Support and Mechanisms
- Renal cell carcinoma treatment
- Vasculitis and related conditions
Seirei Mikatabara General Hospital
2014-2023
Kumamoto University
2019
Wacom (Japan)
2017
University of Wisconsin–Madison
2013
William S. Middleton Memorial Veterans Hospital
2013
Daiichi Sankyo (Germany)
2007
Daiichi University of Pharmacy
1999-2001
Iwate Medical University
1992
DC-159a is a new 8-methoxy fluoroquinolone that possesses broad spectrum of antibacterial activity, with extended activity against gram-positive pathogens, especially streptococci and staphylococci from patients community-acquired infections. showed Streptococcus spp. (MIC(90), 0.12 microg/ml) inhibited the growth 90% levofloxacin-intermediate -resistant strains at 1 microg/ml. The MIC 90s Staphylococcus were 0.5 microg/ml or less. Against quinolone- methicillin-resistant aureus strains,...
Reduced bactericidal efficacy at a high inoculum is known as the effect (IE). We used neutropenic mice to compare IEs of ceftobiprole (CFB), daptomycin (DAP), linezolid (LZD), and vancomycin (VAN) against 6 9 strains Staphylococcus aureus 4 Streptococcus pneumoniae 2 inocula in opposite thighs same mice. Neutropenic had 10(4.5) 10(5.7) CFU/thigh (low [LI]) one thigh 10(6.4) 10(7.2) (high [HI]) when treated for 24 h with subcutaneous (s.c.) doses every 12 DAP 0.024 100 mg/kg body weight LZD...
The antibacterial activities of DK-507k, a novel quinolone, were compared with those other quinolones: ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin, sitafloxacin, and garenoxacin (BMS284756). DK-507k was as active sitafloxacin or up to eightfold more than against Streptococcus pneumoniae, methicillin-susceptible methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci. 4-fold 2- 16-fold gatifloxacin moxifloxacin ciprofloxacin-resistant strains S. including...
Abstract The kidney possesses a highly organised vasculature that is required for its filtration function. While recent advances in stem cell biology have enabled the vitro generation of tissues, at least partially, recapitulation complicated vascular architecture remains huge challenge. Herein we develop method to reconstitute both and , using dissociated sorted mouse embryonic cells. Upon transplantation, arteriolar networks were re-established ran through interstitial space between...
The impact of surfactant therapy on chronic lung disease remains uncertain. During the past decade (1982–91), over 300 babies with respiratory distress syndrome (RDS) weighing 501–2,500 g at birth were consecutively treated surfactant‐TA our neonatal intensive care unit. Data 95 RDS in first 5 year period (Period 1, 1982–86) compared those 158 second 2, 1987–91). Overall improvement was better Period 2 than 1. In converted 98% moderate/severe to ‘near normal’ by 72 hr post‐treatment. 95%...
A non-arthropathic dose and disposition of ofloxacin, a potent new quinolone antimicrobial agent, were assessed in male juvenile (3-month-old) dogs, when administered orally at 5, 10 20 mg/kg/day once daily for 8 consecutive days. Ofloxacin concentrations sera articular cartilages analyzed by high-performance liquid chromatography (HPLC). Macroscopically, arthropathy characterized fluid-filled vesicles surface the humerus femur was observed animals receiving but not those given 5 mg/kg/day....
ABSTRACT DZ-2640 is the ester-type oral carbapenem prodrug of an active parent compound, DU-6681. The pharmacokinetics and safety DU-6681 were investigated in six studies after administration a single dose to healthy male Japanese volunteers at doses 25, 50, 100, 200, 400 mg (as equivalents DU-6681) fasted state. same received drug 100 fed states examine effect food intake on bioavailability DZ-2640. concentrations plasma urine determined by validated high-performance liquid chromatography...
We herein report a 64-year-old man with heparin-induced thrombocytopenia accompanied by anaphylactoid reaction during hemodialysis. The patient was admitted to our hospital acute myocardial infarction and developed kidney injury after percutaneous coronary intervention. When maintenance hemodialysis heparin initiated, the an dyspnea, hypotension, nausea, vomiting. Laboratory tests revealed thrombocytopenia. Immunoglobulin G antibodies heparin-platelet factor 4 complexes were positive,...
化粧品材料や食品添加物として使用されているリゾチームとキトサンをメイラード反応により融合させた複合体（以下LYZOXとする）のCandida albicans の菌糸形発育抑制効果を検討した．C. をLYZOXで3 hr処理して，16 hr菌糸形発育誘発条件で培養した．その結果，LYZOX濃度依存的にカンジダの菌糸形発育が抑制された．LYZOXの原料であるリゾチーム，キトサン，またはリゾチームとキトサンの混合物では菌糸形発育抑制効果は弱かった．さらに，LYZOXと中鎖脂肪酸のデカン酸を併用することで相乗効果を示すことが分かった．その併用効果は高く，70%菌糸形発育阻止時のFIC index値は0.20の低値となった．この組成物について，口腔カンジダ症感染マウスへの防御効果を検証したところ，有意な舌症状の改善が確認された．これらの結果をふまえLYZOXを新たな抗真菌活性素材として開発できる可能性について考察した．
The therapeutic efficacy of oral treatment with levofloxacin, ciprofloxacin, and ampicillin on an experimental pneumonia caused by the penicillin-intermediate Streptococcus pneumoniae for which minimum inhibitory concentrations (MICs) quinolones are similar was assessed in immunocompetent CBA/J mice. Levofloxacin exhibited a dose-dependent effect, achieved complete eradication S. from lungs at 120 mg/kg/day, whereas ciprofloxacin were hardly effective all. A pharmacokinetic study infected...